Imperial College London
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ProfessorHectorKeun

Faculty of Medicine, Department of Surgery & Cancer

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)20 7594 3161h.keun

 
 
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Location

 

officesInstitute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Perng:2016:10.1002/osp4.65,
author = {Perng, W and Oken, E and Roumeliotaki, T and Sood, D and Siskos, AP and Chalkiadaki, G and Dermitzaki, E and Vafeiadi, M and Kyrtopoulos, S and Kogevinas, M and Keun, HC and Chatzi, L},
doi = {10.1002/osp4.65},
journal = {Obesity Science and Practice},
pages = {471--476},
title = {Leptin, acylcarnitine metabolites and development of adiposity in the Rhea mother-child cohort in Crete, Greece.},
url = {http://dx.doi.org/10.1002/osp4.65},
volume = {2},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: This study aims to investigate relations of serum leptin at age 4 with development of adiposity and linear growth during 3 years of follow-up among 75 Greek children and to identify serum metabolites associated with leptin at age 4 and to characterize their associations with adiposity gain and linear growth. METHODS: Linear regression models that accounted for maternal age, education and gestational weight gain and child's age and sex were used to examine associations of leptin and leptin-associated metabolites measured at age 4 with indicators of adiposity and linear growth at age 7. RESULTS: Each 1-unit increment in natural log-(ln)-transformed leptin corresponded with 0.33 (95% CI: 0.10, 0.55) units greater body mass index-for-age z-score gain during follow-up. Likewise, higher levels of the leptin-associated metabolites methylmalonyl-carnitine and glutaconyl-carnitine corresponded with 0.14 (95% CI: 0.01, 0.27) and 0.07 (95% CI: -0.01, 0.16) units higher body mass index-for-age z-score gain, respectively. These relationships did not differ by sex or baseline weight status and were independent of linear growth. CONCLUSIONS: These findings suggest that leptin, methylmalonyl-carnitine and possibly glutaconyl-carnitine are associated with weight gain during early childhood. Future studies are warranted to confirm these findings in other populations.
AU  - Perng,W
AU  - Oken,E
AU  - Roumeliotaki,T
AU  - Sood,D
AU  - Siskos,AP
AU  - Chalkiadaki,G
AU  - Dermitzaki,E
AU  - Vafeiadi,M
AU  - Kyrtopoulos,S
AU  - Kogevinas,M
AU  - Keun,HC
AU  - Chatzi,L
DO  - 10.1002/osp4.65
EP  - 476
PY  - 2016///
SN  - 2055-2238
SP  - 471
TI  - Leptin, acylcarnitine metabolites and development of adiposity in the Rhea mother-child cohort in Crete, Greece.
T2  - Obesity Science and Practice
UR  - http://dx.doi.org/10.1002/osp4.65
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28090353
UR  - http://hdl.handle.net/10044/1/44457
VL  - 2
ER  -
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