Imperial College London
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DrHarryLow

Faculty of Medicine, Department of Infectious Disease

Senior Wellcome Trust Fellow and Proleptic Reader
 
 
 
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Contact

 

+44 (0)20 7594 3064h.low

 
 
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Location

 

260Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Antonny:2016:10.15252/embj.201694613,
author = {Antonny, B and Burd, C and De, Camilli P and Chen, E and Daumke, O and Faelber, K and Ford, M and Frolov, VA and Frost, A and Hinshaw, JE and Kirchhausen, T and Kozlov, MM and Lenz, M and Low, HH and McMahon, H and Merrifield, C and Pollard, TD and Robinson, PJ and Roux, A and Schmid, S},
doi = {10.15252/embj.201694613},
journal = {EMBO Journal},
pages = {1957--2060},
title = {Membrane fission by dynamin: what we know and what we need to know},
url = {http://dx.doi.org/10.15252/embj.201694613},
volume = {35},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The large GTPase dynamin is the first protein shown to catalyze membrane fission. Dynamin and its related proteins are essential to many cell functions, from endocytosis to organelle division and fusion, and it plays a critical role in many physiological functions such as synaptic transmission and muscle contraction. Research of the past three decades has focused on understanding how dynamin works. In this review, we present the basis for an emerging consensus on how dynamin functions. Three properties of dynamin are strongly supported by experimental data: first, dynamin oligomerizes into a helical polymer; second, dynamin oligomer constricts in the presence of GTP; and third, dynamin catalyzes membrane fission upon GTP hydrolysis. We present the two current models for fission, essentially diverging in how GTP energy is spent. We further discuss how future research might solve the remaining open questions presently under discussion.
AU  - Antonny,B
AU  - Burd,C
AU  - De,Camilli P
AU  - Chen,E
AU  - Daumke,O
AU  - Faelber,K
AU  - Ford,M
AU  - Frolov,VA
AU  - Frost,A
AU  - Hinshaw,JE
AU  - Kirchhausen,T
AU  - Kozlov,MM
AU  - Lenz,M
AU  - Low,HH
AU  - McMahon,H
AU  - Merrifield,C
AU  - Pollard,TD
AU  - Robinson,PJ
AU  - Roux,A
AU  - Schmid,S
DO  - 10.15252/embj.201694613
EP  - 2060
PY  - 2016///
SN  - 0261-4189
SP  - 1957
TI  - Membrane fission by dynamin: what we know and what we need to know
T2  - EMBO Journal
UR  - http://dx.doi.org/10.15252/embj.201694613
UR  - http://hdl.handle.net/10044/1/40945
VL  - 35
ER  -
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