Publications
11 results found
Rozati H, Paddick I, Sabin I, 2021, Three-staged stereotactic radiosurgery for brain metastases: a single institution experience, Neuro-Oncology, Vol: 23, Pages: iv20-iv21, ISSN: 1522-8517
<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Aims</jats:title> <jats:p>Stereotactic radiosurgery (SRS) using the Leksell Gamma Knife system is a commonly used modality for the treatment of brain metastases (BMs). As the size of the target volume (TV) increases, so too does the dose of radiation delivered to surrounding healthy tissue. Large BMs are therefore a contraindication to the use of SRS. Critical organs adjacent to the TV may also be a contraindication to SRS. Staged SRS was proposed as a novel method of delivering three SRS treatments at a reduced radiation dose with a gap of two weeks between each session as a way of shrinking the TV. This allows treatment of TVs otherwise considered untreatable with standard, single-fraction SRS. Little data exists in the literature as to its efficacy. The objective of this study was to evaluate the efficacy of this novel approach and to identify factors which may predict treatment failure.</jats:p> </jats:sec> <jats:sec> <jats:title>Method</jats:title> <jats:p>A retrospective analysis was undertaken at a single, tertiary Gamma Knife centre. All patients who underwent treatment of their BMs with three-staged Gamma Knife SRS from January 2014 to December 2020 were identified and included. Patient demographics and primary cancer status was ascertained. SRS treatment details for each lesion were collected, including TV, dose and dosimetric data. The percentage reduction in volume of the TVs between the first and second stage, the second and third stage and the first and third stage were calculated. Follow-up data was collected to include follow-up imaging, further intracranial treatments received and survival status. The percentage reduction in volume between each stage was demonstrated on box-and-whisker plots. Statistical significan
Rozati H, Ferguson FJ, Rashidghamat E, et al., 2020, Delivery of high-dose radiation for recurrence of breast cancer in a patient with hidradenitis suppurativa, BMJ Case Reports, Vol: 13, Pages: e238848-e238848
<jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterised by inflammatory nodules, abscesses, sinus tract formation and scarring. There is a lack of evidence for the use of radical radiotherapy for patients with a diagnosis of HS. A 56-year-old woman with a long-standing diagnosis of HS presented with a cutaneous local recurrence of breast cancer. Radical radiotherapy was offered despite issues with previous prolonged postoperative wound healing associated with the underlying HS. A multidisciplinary evaluation was conducted with breast surgeons, dermatologists and radiation oncologists to assess the safety of delivery of radical radiotherapy. Five weeks post radiotherapy, the patient had no significant residual symptoms from her breast cancer treatment for her HS and no escalation of treatment was required for her HS. Factors contributing to safe delivery of radical radiotherapy include medical optimisation prior to and during treatment, radiation dose, radiation technique and vigilant post-treatment surveillance.</jats:p>
Kühnl A, Cunningham D, Hutka M, et al., 2018, Rapid access clinic for unexplained lymphadenopathy and suspected malignancy: prospective analysis of 1000 patients, BMC Hematology, Vol: 18
Rozati H, Handley T, Jayasena C, 2017, Process and Pitfalls of Sperm Cryopreservation, JOURNAL OF CLINICAL MEDICINE, Vol: 6
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Saxby H, Rozati H, Shousa S, et al., 2016, The management of ductal carcinoma in-situ at Charing Cross Hospital, European Journal of Surgical Oncology (EJSO), Vol: 42, Pages: S221-S221, ISSN: 0748-7983
Rozati H, Shah SP, Shah N, 2015, Smartphone Applications for the Clinical Oncologist in UK Practice, Journal of Cancer Education, Vol: 30, Pages: 367-373, ISSN: 0885-8195
Rozati H, Zafar S, Trevatt A, et al., 2014, Sa1096 How Well Do We Investigate Iron Deficiency Anaemia With Colonoscopy Following a Normal Gastroscopy?, Gastroenterology, Vol: 146, Pages: S-198, ISSN: 0016-5085
Shah N, Shah SP, Thakrar A, et al., 2014, An adhesion-related small bowel obstruction occurring within 36 h of a total abdominal hysterectomy and bilateral salpingo-oophorectomy, Case Reports, Vol: 2014, Pages: bcr2013201507-bcr2013201507, ISSN: 1757-790X
Shah N, Fernandes R, Thakrar A, et al., 2013, Diaphragmatic hernia: an unusual presentation, Case Reports, Vol: 2013, Pages: bcr2013008699-bcr2013008699, ISSN: 1757-790X
Rozati H, Shah SP, Peng YY, 2013, Lower limb gangrene postcardiac surgery, Case Reports, Vol: 2013, Pages: bcr2012008362-bcr2012008362, ISSN: 1757-790X
Rozati H, Jaffer ZN, Al-Hadithy N, 2012, A young man with wrist pain, BMJ, Vol: 345, Pages: e4466-e4466
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