Publications
139 results found
Brookes N, Saleh H, Mackay I, et al., 2002, 10-Minute consultation: Rhinitis [9] (multiple letters), British Medical Journal, Vol: 324, Pages: 1219-1220, ISSN: 0959-8146
Saleh HA, Lohuis PJFM, Vuyk HD, 2002, Bone resorption after alloplastic augmentation of the mandible., Clin Otolaryngol Allied Sci, Vol: 27, Pages: 129-132, ISSN: 0307-7772
Augmentation mentoplasty is a commonly performed operation especially in conjunction with rhinoplasty. While various materials have previously been used for this procedure, silastic has been the implant of choice for the last three decades. Concerns have been raised due to the occurrence of bone resorption beneath these implants. Controversy prevails as to the cause and the long-term effects of the resorption. It has been suggested by some that the resorption is self-limiting although this has not been confirmed in clinical studies. In total, 40 patients with silastic implants, who had a mean follow-up of 20 months (8-60 months), were studied radiologically. In 21 of them (52%), a degree of resorption from 0.5 to 2 mm was observed. Spearman's rank correlation showed a statistically significant relationship between the degree of resorption and the time lapse since surgery (P = 0.048).
Hesham Saleh, Valerie Lund, 2001, The Nose as a Target of Air Pollution, The European Respiratory Monograph: The Nose and Lung Diseases, Editors: Wallaert, Chanez, Godard
Birch DS, Saleh HA, Wodehouse T, et al., 2001, Assessing the quality of life for patients with chronic rhinosinusitis using the "Rhinosinusitis Disability Index"., Rhinology, Vol: 39, Pages: 191-196, ISSN: 0300-0729
Quality of life studies are increasingly being use as the primary outcome measure in chronic rhinosinusitis. The Rhinosinusitis Disability Index (RSDI) is a recently designed validated measure that has not been used in clinical studies. We have used the RSDI on 53 patients with chronic rhinosinusitis and compared the results to their endoscopic score and self-rated symptom score. Our data showed that the mean total quality of life score was 42 with a range of 5 to 69 (SD 17). The means of the functional, emotional and physical domains were 13 (range 0 to 27, SD 6), 13 (range 0 to 25, SD 7) and 16 (range of 2 to 32, SD of 7) respectively. There was no correlation between endoscopic score and either the patient's self-rated symptom score or RSDI score. The correlation between the self-rated symptom score and total quality of life score was significant (p = 0.02). Various areas of the patients' quality of life were shown to be affected by chronic rhinosinusitis.
El-Hakim H, Nunez DA, Saleh HA, et al., 2000, A randomised controlled trial of the effect of regional nerve blocks on immediate post-tonsillectomy pain in adult patients., Clin Otolaryngol Allied Sci, Vol: 25, Pages: 413-417, ISSN: 0307-7772
Post-operative pain is the main cause of morbidity following tonsillectomy. The efficacy of glossopharyngeal and lesser palatine nerve blocks in controlling postoperative pain in adult patients was investigated prospectively. Patients 16 years and older admitted for elective tonsillectomy were randomised to one of three groups to receive a pre-incisional oropharyngeal injection of 0.5% bupivicaine, a 'dummy' injection of saline or no injection. Dissection tonsillectomy and general anaesthetic techniques were standardized. Postoperative pain was monitored for 24 h. ANOVA, chi2 and Fisher's exact test were used for intergroup comparisons. Ninety-two patients (72 women and 20 men), mean age 22 years were studied. Twenty-nine patients received 0.5% bupivicaine, 30 saline and 33 no pre-incisional injection. The overall mean pain scores of 2.1, 1.9 and 1.9 in the bupivicaine, saline and no injection groups were similar. Glossopharyngeal and lesser palatine 0.5% bupivicaine nerve blocks are not effective in reducing early post-tonsillectomy pain.
Sandhu G, Saleh HA, Wright T, 2000, Amoxicillin for otitis media in general practice. Study raises concerns., BMJ, Vol: 321, ISSN: 0959-8138
Ram B, White PS, Saleh HA, et al., 2000, Endoscopic endonasal ligation of the sphenopalatine artery., Rhinology, Vol: 38, Pages: 147-149, ISSN: 0300-0729
Internal maxillary artery ligation for persistent posterior epistaxis is traditionally performed via the transantral approach. Although usually effective in controlling the bleeding it carries significant risks, including damage to the infraorbital nerve, damage to dentition and oro-antral fistula formation. The alternative procedure of endoscopic ligation of the sphenopalatine artery at its exit from the sphenopalatine foramen avoids the morbidity associated with the transantral approach. The technique we describe involves the use of standard FESS instruments and a Ligge Clip applicator. This operation is well within the capability of the Otolaryngologist/Rhinologist experienced in endoscopic sinus surgery.
Hall W, Ogden GR, Saleh AH, et al., 2000, Fluid phase endocytosis in oral epithelia: variation with site and effect of cancer., J Oral Pathol Med, Vol: 29, Pages: 220-225, ISSN: 0904-2512
The structure of the oral mucosa has been extensively studied but its cell physiology has been less well characterised. This study aimed to show the range in variation in fluid phase endocytic capability in biopsies from different oral sites. Oral epithelial cells were obtained from both biopsies and single-cell suspensions obtained by brushing the oral cavity. Biopsies in organ culture and single cells in suspension were incubated with fluorescent microspheres of 0.02, 0.1 or 1.0 microm diameter. Endocytosis of fluorescent microspheres was quantitated by flow cytometry and visualised by confocal microscopy. Epithelial cells from all oral sites that were sampled internalised 0.02 microm and 0.1 microm but not 1.0 microm microspheres, with no significant differences observed between oral regions. Single cells from non-cancer patients endocytosed significantly more 0.02 microm microspheres than cells removed from patients with oral cancer. This model may be used to study integrated oral cell function both in health and disease.
Saleh HA, Lund VJ, 2000, Treating nasal polyps., Practitioner, Vol: 244, Pages: 84-93, ISSN: 0032-6518
Waddell A, Saleh H, Robertson N, et al., 2000, Thyroglossal duct remnants., J Laryngol Otol, Vol: 114, Pages: 128-129, ISSN: 0022-2151
Thyroglossal duct remnants presenting as a lump in the neck are usually called thyroglossal cysts. Meticulous dissection of the cyst and duct, along with the body of the hyoid bone (Sistrunk's operation) is necessary to avoid recurrence. The authors have reviewed the histology of 61 consecutive specimens diagnosed preoperatively as thyroglossal cysts and have found that a true cyst exists in only 46 per cent of cases.
Cain AJ, Odutoye TA, Saleh HA, 2000, Unravelling the tangle of the web - How to set up your own departmental internet site., CME Bulletin Otorhinolaryngology Head and Neck Surgery, Vol: 4, Pages: 25-26, ISSN: 1364-8829
The internet has become ubiquitous, it is now virtually impossible to turn on the television or read a newspaper without being bombarded with internet articles, advertisements or corporate addresses. We have recently created a website in the Directorate of Otolaryngology in Dundee and outline the technological changes in recent years which allow any department or individual to set up such a site. We explain in simple terms the stages involved and how to avoid the complications and pitfalls involved in what should be essentially a straightforward project.
Khan-Lim D, Ellis J, Saleh H, et al., 1999, Endoscopic transnasal removal of orbital foreign body., Eye (Lond), Vol: 13 ( Pt 5), Pages: 667-668, ISSN: 0950-222X
Saleh HA, Mills RP, 1999, Classification and staging of cholesteatoma., Clin Otolaryngol Allied Sci, Vol: 24, Pages: 355-359, ISSN: 0307-7772
No staging system for cholesteatoma has been universally adopted. All previous attempts failed to gain acceptance because of the lack of clinical relevance. We have devised a simple system to stage cholesteatoma which is based on the extent of lesion, ossicular condition and the preoperative complications. To illustrate the systems potential value, data from 119 new patients with cholesteatoma are presented and classified according to our proposed scheme. This shows a relationship between the stage of disease, ossicular damage and the occurrence of complications. The proposed staging system is potentially useful when considering the type of surgery required and when comparing published data reporting the results of tympanomastoid surgery.
Saleh HA, Cain AJ, Mountain RE, 1999, Bipolar scissor division of tongue-tie under tubeless anesthesia., Laryngoscope, Vol: 109, Pages: 838-839, ISSN: 0023-852X
Saleh HA, Cain AJ, Mountain RE, 1999, Bipolar scissor tonsillectomy., Clin Otolaryngol Allied Sci, Vol: 24, Pages: 9-12, ISSN: 0307-7772
We describe a new technique for tonsillectomy using dual-function scissors that cut and bipolar coagulate at the same time. The technique shortens operating time and decreases intra-operative blood loss. Forty patients had their tonsillectomy performed using this technique. The mean operating time was 5.5 min (SD 2.1) and mean blood loss was 1.3 ml (SD 3.6). All patients were able to eat and drink on the same postoperative day and all were discharged the following morning. None of the patients had primary haemorrhages and two patients (5%) had minor secondary haemorrhages. We found bipolar scissor tonsillectomy to be a safe technique that shortens surgery and minimises blood loss without causing increased postoperative morbidity.
Axford SE, Ogden GR, Stewart AM, et al., 1999, Fluid phase endocytosis within buccal mucosal cells of alcohol misusers., Oral Oncol, Vol: 35, Pages: 86-92, ISSN: 1368-8375
The structure of the oral mucosa is now well characterised, although studies on oral epithelial cell function have received less attention. The aims of this study were to see whether endocytosis could be demonstrated in cells from oral smears and if so, to assess the effect of chronic high alcohol intake on such uptake. Buccal mucosal smears were collected from 135 patients (91 non- or social drinkers, and 44 patients with harmful alcohol use). Name, age, sex, and alcohol history (for alcohol problem patients) were recorded. Cell suspensions were incubated in a solution of bovine serum albumin (BSA)-coated fluorescently labelled latex microspheres (0.02 micron diameter) in Ham's F-10 culture medium for 1 h at 37 degrees C as a marker of fluid phase endocytosis. Uptake of microspheres was confirmed by confocal microscopy, and mean endocytosed fluorescence levels determined by flow cytometry. A repeat smear from 11 of the alcohol patients was taken 9-14 days later. Endocytosis was significantly reduced in both male (P < 0.01) and female (P < 0.01) alcohol problem patients compared to controls. Units of alcohol consumed and cigarettes smoked per day did not show a dose-response correlation with endocytosis in the alcohol problem patients. Apparent abstinence from alcohol had no further effect on endocytic uptake at days 9-14. This study shows that normal oral squamous cells removed as buccal smears readily endocytose fluorescent microspheres and that this capacity can be affected by alcohol. Chronic high alcohol intake would appear to down regulate endocytosis in buccal cells even up to 14 days of abstinence. This may have implications for the pathogenesis of oral mucosal disorders in long-term users.
Ram B, Saleh HA, Baird AR, et al., 1998, Verrucous carcinoma of the maxillary antrum., J Laryngol Otol, Vol: 112, Pages: 399-402, ISSN: 0022-2151
Verrucous carcinoma is a distinct variant of well differentiated squamous cell carcinoma. Its occurrence in the maxillary antrum is rare. Only three cases have previously been documented. We present a case report of verrucous carcinoma in the maxillary antrum and a review of the literature.
Saleh HA, Bridger MW, 1997, Invasive aspergillosis of the paranasal sinuses: a medical emergency., J Laryngol Otol, Vol: 111, Pages: 1168-1170, ISSN: 0022-2151
A rare case of invasive aspergillosis of the paranasal sinuses in a previously healthy individual is presented. The disease caused severe complications and proved fatal. Classification, aetiology and presentation of sinus aspergillosis are discussed. Early diagnosis and management is stressed to avoid the high incidence of morbidity and mortality.
Saleh HA, 1996, A case of prostatic cancer metastatic to the orbit and ethmoid sinus., Ann Otol Rhinol Laryngol, Vol: 105, ISSN: 0003-4894
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