Imperial College London
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Professor Hesham Saleh

Faculty of Medicine, Department of Surgery & Cancer

Professor of Practice (Rhinology)
 
 
 
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Contact

 

+44 (0)20 3311 1025h.saleh Website

 
 
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Location

 

Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bujoreanu:2020:10.1136/bcr-2020-235240,
author = {Bujoreanu, I and Ferguson, M and Saleh, H},
doi = {10.1136/bcr-2020-235240},
journal = {BMJ Case Reports},
pages = {1--4},
title = {Chemotherapy associated dural sinus thrombosis presenting as a cerebrospinal fluid leak.},
url = {http://dx.doi.org/10.1136/bcr-2020-235240},
volume = {13},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Despite the well documented increased risk of thrombosis in patients with cancer and during chemotherapy, cerebral venous sinus thrombosis (CVT) remains a rare entity. We present a rare case of cerebrospinal fluid (CSF) rhinorrhoea secondary to a left transverse sinus thrombus which occurred 2 years previously during chemotherapy for breast cancer. The patient underwent a three-layer repair using Neuro-Patch, septal cartilage and middle turbinate pedicle flap and was started on acetazolamide. There was no recurrence at 1-year follow-up. Raised intracranial pressure secondary to cerebral venous occlusion can erode the base of skull and predispose to CSF leaks. Despite the theoretical risk, there have been no cases reported where CSF leaks have occurred following chemotherapy induced CVT. We describe the first case and discuss pathophysiology and management.
AU  - Bujoreanu,I
AU  - Ferguson,M
AU  - Saleh,H
DO  - 10.1136/bcr-2020-235240
EP  - 4
PY  - 2020///
SN  - 1757-790X
SP  - 1
TI  - Chemotherapy associated dural sinus thrombosis presenting as a cerebrospinal fluid leak.
T2  - BMJ Case Reports
UR  - http://dx.doi.org/10.1136/bcr-2020-235240
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32487533
UR  - https://casereports.bmj.com/content/13/6/e235240
VL  - 13
ER  -
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