Imperial College London

ProfessorHowardThomas

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Emeritus Professor of Hepatology
 
 
 
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Contact

 

+44 (0)20 3312 6454h.thomas

 
 
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Assistant

 

Ms Dawn Campbell +44 (0)20 3312 6454

 
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Location

 

1049 and 1050Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

407 results found

Wadsworth CA, Dixon PH, Taylor-Robinso SD, Kim JU, Zabron AA, Wong JH, Chapman MH, McKay SC, Spalding DR, Wasan HS, Pereira SP, Thomas HC, Whittaker JC, Williamson C, Khan SAet al., 2019, Polymorphisms in natural killer cell receptor protein 2D (NKG2D) as a risk factor for Cholangiocarcinoma, Journal of Clinical and Experimental Hepatology, Vol: 9, Pages: 171-175, ISSN: 0973-6883

Background and aims: Understanding of the significant genetic risk factors for Cholangiocarcinoma (CC) remains limited. Polymorphisms in the natural killer cell receptor G2D (NKG2D) gene have been shown to increase risk of CC transformation in patients with Primary Sclerosing Cholangitis (PSC). We present a validation study of NKG2D polymorphisms in CC patients without PSC. Methods: Seven common Single Nucleotide Polymorphisms (SNPs) of the NKG2D gene were genotyped in 164 non-PSC related CC subjects and 257 controls with HaploView. The two SNPs that were positively identified in the previous Scandinavian study, rs11053781 and rs2617167, were included. Results: The seven genotyped SNPs were not associated with risk of CC. Furthermore, haplotype analysis revealed that there was no evidence to suggest that any haplotype differs in frequency between cases and controls (P > 0.1). Conclusion: The common genetic variation in NKG2D does not correlate significantly with sporadic CC risk. This is in contrast to the previous positive findings in the Scandinavian study with PSC-patients. The failure to reproduce the association may reflect an important difference between the pathogenesis of sporadic CC and that of PSC-related CC. Given that genetic susceptibility is likely to be multifaceted and complex, further validation studies that include both sporadic and PSC-related CC are required.

Journal article

Papatheodoridis G, Thomas HC, Golna C, Bernardi M, Carballo M, Cornberg M, Dalekos G, Degertekin B, Dourakis S, Flisiak R, Goldberg D, Gore C, Goulis I, Hadziyannis S, Kalamitsis G, Kanavos P, Kautz A, Koskinas I, Leite BR, Malliori M, Manolakopoulos S, Maticic M, Papaevangelou V, Pirona A, Prati D, Raptopoulou-Gigi M, Reic T, Robaeys G, Schatz E, Souliotis K, Tountas Y, Wiktor S, Wilson D, Yfantopoulos J, Hatzakis Aet al., 2016, Addressing barriers to the prevention, diagnosis and treatment of hepatitis B and C in the face of persisting fiscal constraints in Europe: report from a high level conference, JOURNAL OF VIRAL HEPATITIS, Vol: 23, Pages: 1-12, ISSN: 1352-0504

Journal article

Walsh R, Hammond R, Yuen L, Bayliss J, Revill PA, Leary T, Thomas H, Gaggar A, Subramanian M, Kitrinos KM, Thompson AJ, Locarnini Set al., 2015, Mapping HBsAg epitope profiles to predict HBsAg loss/seroconversion in a treatment naive cohort of genotype A chronic hepatitis B (CHB) patients receiving tenofovir disoproxil fumarate (TDF) therapy, 66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Publisher: WILEY-BLACKWELL, Pages: 966A-967A, ISSN: 0270-9139

Conference paper

Bermingham SL, Hughes R, Fenu E, Sawyer LM, Boxall E, Kennedy PT, Dusheiko G, Hill-Cawthorne G, Thomas Het al., 2015, Cost-Effectiveness Analysis of Alternative Antiviral Strategies for the Treatment of HBeAg-Positive and HBeAg-Negative Chronic Hepatitis B in the United Kingdom, VALUE IN HEALTH, Vol: 18, Pages: 800-809, ISSN: 1098-3015

Journal article

Bridge SH, Sheridan DA, Felmlee DJ, Crossey MME, Fenwick FI, Lanyon CV, Dubuc G, Seidah NG, Davignon J, Thomas HC, Taylor-Robinson SD, Toms GL, Neely RDG, Bassendine MFet al., 2015, PCSK9, apolipoprotein E and lipoviral particles in chronic hepatitis C genotype 3: Evidence for genotype-specific regulation of lipoprotein metabolism, JOURNAL OF HEPATOLOGY, Vol: 62, Pages: 763-770, ISSN: 0168-8278

Journal article

Lim LY, Yuen L, Hammond R, Angus PW, Thompson AJ, Patterson SJ, Leary T, Yi P, Thomas H, Locarnini S, Walsh Ret al., 2014, Mapping the HBsAg immune phenotype to predict HBsAg decline in chronic hepatitis B in patients receiving nucleot(s)ide analogue therapy, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol: 29, Pages: 154-154, ISSN: 0815-9319

Journal article

Sheridan DA, Bridge SH, Crossey MME, Felmlee DJ, Thomas HC, Neely RDG, Taylor-Robinson SD, Bassendine MFet al., 2014, Depressive symptoms in chronic hepatitis C are associated with plasma apolipoprotein E deficiency, METABOLIC BRAIN DISEASE, Vol: 29, Pages: 625-634, ISSN: 0885-7490

Journal article

Sheridan DA, Bridge SH, Crossey MME, Felmlee DJ, Fenwick FI, Thomas HC, Neely RDG, Taylor-Robinson SD, Bassendine MFet al., 2014, Omega-3 fatty acids and/or fluvastatin in hepatitis C prior non-responders to combination antiviral therapy - a pilot randomised clinical trial, LIVER INTERNATIONAL, Vol: 34, Pages: 737-747, ISSN: 1478-3223

Journal article

Lim LY, Yuen L, Hammond R, Angus PW, Thompson AJ, Patterson S, Leary T, Yin P, Thomas H, Locarnini S, Walsh Ret al., 2014, Mapping the HBsAg immune phenotype to predict HBsAg loss or decline in chronic hepatitis B in patients receiving nucleot(s)ide analogue therapy, 65th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Publisher: WILEY-BLACKWELL, Pages: 980A-980A, ISSN: 0270-9139

Conference paper

Forton DM, Taylor-Robinson SD, Gess M, Crossey M, Thomas HCet al., 2013, Central nervous system complications of hepatitis C virus infection, Viral Hepatitis, Editors: Thomas, Lok, Locarnini, Zuckerman, Oxford, Publisher: Wiley-Blackwell, ISBN: 9780470672952

The latest edition of Viral Hepatitis offers an essential resource of current information for hepatologists, gastroenterologists, infectious diseases specialists and other clinicians, researchers, public health physicians and National and ...

Book chapter

Hatzakis A, Van Damme P, Alcorn K, Gore C, Benazzouz M, Berkane S, Buti M, Carballo M, Cortes Martins H, Deuffic-Burban S, Dominguez A, Donoghoe M, Elzouki A-N, Bouafif NB-A, Esmat G, Esteban R, Fabri M, Fenton K, Goldberg D, Goulis I, Hadjichristodoulou T, Hatzigeorgiou T, Hamouda O, Hasurdjiev S, Hughes S, Kautz A, Malik M, Manolakopoulos S, Maticic M, Papatheodoridis G, Peck R, Peterle A, Potamitis G, Prati D, Roudot-Thoraval F, Reic T, Sharara A, Shennak M, Shiha G, Shouval D, Socan M, Thomas H, Thursz M, Tosti M, Trepo C, Vince A, Vounou E, Wiessing L, Manns Met al., 2013, The State of Hepatitis B and C in the Mediterranean and Balkan Countries: Report from a Summit Conference, JOURNAL OF VIRAL HEPATITIS, Vol: 20, Pages: 1-20, ISSN: 1352-0504

Journal article

Sarri G, Westby M, Bermingham S, Hill-Cawthorne G, Thomas Het al., 2013, GUIDELINES Diagnosis and management of chronic hepatitis B in children, young people, and adults: summary of NICE guidance, BMJ-BRITISH MEDICAL JOURNAL, Vol: 346, ISSN: 1756-1833

Journal article

Sheridan DA, Bridge SH, Crossey MME, Felmlee DJ, Fenwick F, Thomas HC, Neely D, Taylor-Robinson SD, Bassendine MFet al., 2013, OMEGA-3 FATTY ACIDS AND/OR FLUVASTATIN IN HEPATITIS C PRIOR NON-RESPONDERS TO COMBINATION ANTI-VIRAL THERAPY - A PILOT RANDOMISED CLINICAL TRIAL, International Liver Congress / 48th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S372-S372, ISSN: 0168-8278

Conference paper

McPhail MJW, Leech R, Grover VPB, Fitzpatrick JA, Dhanjal NS, Crossey MME, Pflugrad H, Saxby BK, Wesnes K, Dresner MA, Waldman AD, Thomas HC, Taylor-Robinson SDet al., 2013, Modulation of neural activation following treatment of hepatic encephalopathy, NEUROLOGY, Vol: 80, Pages: 1041-1047, ISSN: 0028-3878

Journal article

Khan SA, Davidson BR, Goldin RD, Heaton N, Karani J, Pereira SP, Rosenberg WMC, Tait P, Taylor-Robinson SD, Thillainayagam AV, Thomas HC, Wasan Het al., 2012, Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update, GUT, Vol: 61, Pages: 1657-1669, ISSN: 0017-5749

Journal article

Sheridan DA, Bridge SH, Felmlee DJ, Crossey MME, Thomas HC, Taylor-Robinson SD, Toms GL, Neely RDG, Bassendine MFet al., 2012, Apolipoprotein-E and hepatitis C lipoviral particles in genotype 1 infection: Evidence for an association with interferon sensitivity, JOURNAL OF HEPATOLOGY, Vol: 57, Pages: 32-38, ISSN: 0168-8278

Journal article

Cobbold JFL, Cox IJ, Brown AS, Williams HRT, Goldin RD, Thomas HC, Thursz MR, Taylor-Robinson SDet al., 2012, Lipid profiling of pre-treatment liver biopsy tissue predicts sustained virological response in patients with chronic hepatitis C, Hepatology Research, Vol: 42, Pages: 714-720, ISSN: 1386-6346

Aim: Hepatic lipid is important in the pathogenesis and progression of hepatitis C-related liver disease. Polyunsaturated fatty acids have been shown to reduce viral replication in cell culture. Proton magic angle spinning magnetic resonance spectroscopy (1H MAS MRS) enables metabolic analysis of intact tissue. The aim was to examine the relationship between hepatic lipid composition by metabolic profiling of liver tissue at baseline and treatment response to pegylated-Interferon alfa2 and Ribavirin.Methods: Baseline liver biopsy samples from 31 patients with chronic hepatitis C were analyzed histologically and by 1H MAS MRS. Indices of lipid composition were derived and partial least squares discriminant analysis with cross-validation was used to predict treatment outcome.Results: Of 31 patients, 14 achieved sustained virological response (SVR). Lipid polyunsaturation (median (IQR)) was higher in SVR (3.41% (2.31)) than in treatment failure (TF) (2.15% (1.51)), P = 0.02. Lipid saturation was lower in SVR (85.9% (3.39)) than TF (86.7% (2.17)), P = 0.04. The total lipid content was lower in SVR (1.54% (0.81)) than TF (2.72% (3.47)), P = 0.004. Total choline to lipid ratio was higher in SVR (11.51% (9.99)) than TF (7.5% (6.82)), P = 0.007. Cross-validation correctly predicted the SVR group in 13 of 14 samples with 1 sample misclassified, and the TF group in all 17 samples.Conclusions: Lipid polyunsaturation was greater and total lipid lower in those with SVR, compared with TF. Metabolic profiling of intact liver biopsy samples predicted SVR with high accuracy. Hepatic lipid composition may impact on treatment success.

Journal article

Cobbold JFL, Patel D, Fitzpatrick JA, Patel N, Crossey MME, AbdAlla MS, Goldin RD, Vennart W, Thomas HC, Taylor-Robinson SDet al., 2012, Accuracy and reliability of microbubble ultrasound measurements for the non-invasive assessment of hepatic fibrosis in chronic hepatitis C, HEPATOLOGY RESEARCH, Vol: 42, Pages: 515-522, ISSN: 1386-6346

Journal article

Patel M, Shariff MIF, Ladep NG, Thillainayagam AV, Thomas HC, Khan SA, Taylor-Robinson SDet al., 2012, Hepatocellular carcinoma: diagnostics and screening, JOURNAL OF EVALUATION IN CLINICAL PRACTICE, Vol: 18, Pages: 335-342, ISSN: 1356-1294

Journal article

Khan SA, Emadossadaty S, Ladep NG, Thomas HC, Elliott P, Taylor-Robinson SD, Toledano MBet al., 2012, Rising trends in cholangiocarcinoma: Is the ICD classification system misleading us?, JOURNAL OF HEPATOLOGY, Vol: 56, Pages: 848-854, ISSN: 0168-8278

Journal article

McPhail MJ, Thomas HC, Taylor-Robinson HC, 2012, Magnetic Resonance Studies of the Brain in Liver Disease, Functional Molecular Imaging in Hepatology, Editors: Keiding, Sorensen, Bussum Netherlands, Publisher: Bentham Books, Pages: 160-182, ISBN: 978-1-60805-290-5

The diverse neurological manifestations of liver disease pose a diagnostic challenge for modern hepatologists with magnetic resonance (MR) techniques representing a highly profitable avenue to investigate structural and functional aspects of brain dysfunction. The commonest, but not sole neurological manifestation of liver disease, hepatic encephalopathy (HE), is a sequel of both acute and chronic liver failure, ranging from cognitive impairment only detectable on psychometric evaluation through to confusion, coma and death from cerebral edema. While there is widespread acceptance of its importance, there is little consensus on how best to diagnose and monitor HE. Clinical descriptions, psychometric testing, electroencephalography (EEG) and lately, imaging techniques, such as magnetic resonance (MR) imaging, MR spectroscopy and positron emission tomography (PET) have all have their proponents, but most putatively diagnostic paradigms remain the preserve of research establishments with an interest in HE. Of note, modern clinical MRI scanners with multinuclear MR spectroscopy capabilities and brain mapping software can objectively demonstrate structural and functional cellular changes (such as brain size and astrocyte swelling) using volumetric MRI, magnetization transfer MRI, diffusion-weighting MRI, functional MRI with oxygenation measurements and in vivo 1H and 31P MR spectroscopy, with the option of performing many sequences at a single sitting to maximize information gathering and cohort characterization. These techniques are also transferable to characterize non-HE cases of neurological dysfunction in liver disease, such as primary biliary cirrhosis, the neuropsychiatric sequela of non-cirrhotic chronic hepatitis C infection and metal deposition disorders, such as Wilson’s disease and hemochromatosis. This chapter describes the relative merits of these MR techniques and provides guidance on the directions for future research and translational into clinical

Book chapter

Grover VPB, Pavese N, Koh S-B, Wylezinska M, Saxby BK, Gerhard A, Forton DM, Brooks DJ, Thomas HC, Taylor-Robinson SDet al., 2012, Cerebral microglial activation in patients with hepatitis c: in vivo evidence of neuroinflammation, JOURNAL OF VIRAL HEPATITIS, Vol: 19, Pages: E89-E96, ISSN: 1352-0504

Journal article

Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga J-J, Kuehnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Leach IM, O'Reilly PF, Peden JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJC, Dixon AL, Doering A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB, Hartikainen A-L, Heath S, Hirschfield GM, Hofman A, Homuth G, Hyppoenen E, Janssen HLA, Johnson T, Kangas AJ, Kema IP, Kuehn JP, Lai S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin J-P, Loos RJF, Martin NG, Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y, O'Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JNL, Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM, Tukiainen T, Uitterlinden AG, Van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H, Wichmann H-E, Willemsen G, Wuertz P, Xu C, Yerges-Armstrong LM, Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy MI, Meisinger C, Mooser V, Pietilainen KH, Schumann G, Snieder H, Sternberg MJE, Stolk RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield JB, Witteman JCM, Wolffenbuttel BHR, Fox CS, Ala-Korpela M, Stefansson K, Vollenweider P, Voelzke H, Schadt EE, Scott J, Jarvelin M-R, Elliott P, Kooner JSet al., 2011, Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma, NATURE GENETICS, Vol: 43, Pages: 1131-1138, ISSN: 1061-4036

Journal article

Lim AKP, Patel N, Eckersley RJ, Fitzpatrick J, Crossey MME, Hamilton G, Goldin RD, Thomas HC, Vennart W, Cosgrove DO, Taylor-Robinson SDet al., 2011, A comparison of P-31 magnetic resonance spectroscopy and microbubble-enhanced ultrasound for characterizing hepatitis c-related liver disease, JOURNAL OF VIRAL HEPATITIS, Vol: 18, Pages: E530-E534, ISSN: 1352-0504

Journal article

Bridge S, Sheridan D, Felmlee D, Crossey M, Thomas H, Taylor-Robinson S, Toms G, Neely D, Bassendine Met al., 2011, APOLIPOPROTEIN E AND LOW-DENSITY, APOLIPOPROTEIN B ASSOCIATED LIPOVIRAL PARTICLES IN CHRONIC HEPATITIS C INFECTION: EVIDENCE FOR GENOTYPE-SPECIFIC MODULATION OF LIPID PATHWAYS, GUT, Vol: 60, Pages: A24-A24, ISSN: 0017-5749

Journal article

Hatzakis A, Wait S, Bruix J, Buti M, Carballo M, Cavaleri M, Colombo M, Delarocque-Astagneau E, Dusheiko G, Esmat G, Esteban R, Goldberg D, Gore C, Lok ASF, Manns M, Marcellin P, Papatheodoridis G, Peterle A, Prati D, Piorkowsky N, Rizzetto M, Roudot-Thoraval F, Soriano V, Thomas HC, Thursz M, Valla D, van Damme P, Veldhuijzen IK, Wedemeyer H, Wiessing L, Zanetti AR, Janssen HLAet al., 2011, The state of hepatitis B and C in Europe: report from the hepatitis B and C summit conference, JOURNAL OF VIRAL HEPATITIS, Vol: 18, Pages: 1-16, ISSN: 1352-0504

Journal article

Sauvage VR, Levene AP, Nguyen HT, Wood TC, Kudo H, Concas D, Thomas HC, Thursz MR, Goldin RD, Anstee QM, Elson DSet al., 2011, Multi-Excitation Fluorescence Spectroscopy for Analysis of Non-Alcoholic Fatty Liver Disease, LASERS IN SURGERY AND MEDICINE, Vol: 43, Pages: 392-400, ISSN: 0196-8092

Journal article

AbdAlla MSH, Taylor-Robinson SD, Sharif AW, Williams HRT, Crossey MME, Badra GA, Thillainayagam AV, Bansi DS, Thomas HC, Waked IA, Khan SAet al., 2011, Differences in phosphatidylcholine and bile acids in bile from Egyptian and UK patients with and without cholangiocarcinoma, HPB, Vol: 13, Pages: 385-390, ISSN: 1365-182X

Journal article

Bridge SH, Sheridan DA, Felmlee DJ, Nielsen SU, Thomas HC, Taylor-Robinson SD, Neely RDG, Toms GL, Bassendine MFet al., 2011, Insulin resistance and low-density apolipoprotein B-associated lipoviral particles in hepatitis C virus genotype 1 infection, GUT, Vol: 60, Pages: 680-687, ISSN: 0017-5749

Journal article

Wylezinska M, Cobbold JFL, Fitzpatrick J, McPhail MJW, Crossey MME, Thomas HC, Hajnal JV, Vennart W, Cox IJ, Taylor-Robinson SDet al., 2011, A comparison of single-voxel clinical in vivo hepatic P-31 MR spectra acquired at 1.5 and 3.0 Tesla in health and diseased states, NMR IN BIOMEDICINE, Vol: 24, Pages: 231-237, ISSN: 0952-3480

Journal article

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