Summary
The main focus of my current research is to extend existing deterministic and individual-based mathematical models that can inform malaria eradication strategies - how, where and when should resources be invested to most effectively reduce the global case burden and eventually eradicate Plasmodium parasites?
I also work on determining the cost-effectiveness of the recently recommended RTS,S/AS01 and R21/Matrix-M malaria vaccines, relative to scale-up of existing interventions such as insecticide-treated nets and seasonal malaria chemoprevention.
Prior to my post-doc I worked on HIV, sickle cell disease, Burkitt’s lymphoma, cervical cancer, and the RTS,S malaria vaccine. I have spent time living abroad in Kenya and Malawi, working with the U.S. National Cancer Institute’s Center for Global Health, national Ministries of Health, and other academic partners. I also serve as an epidemiology consultant for the Pan African Academy of Christian Surgeons (PAACS) and a member of the African Esophageal Cancer Consortium (AfrECC).
Selected Publications
Journal Articles
Gumbo A, Topazian HM, Mwanza A, et al., 2021, Occurrence and Distribution of Non-falciparum Malaria Parasite Species among Adolescents and Adults in Malawi., The Journal of Infectious Diseases
Topazian HM, Gumbo A, Brandt K, et al., 2021, Effectiveness of a national mass distribution campaign of long-lasting insecticide-treated nets and indoor residual spraying on clinical malaria in Malawi, 2018-2020., Bmj Global Health, Vol:6
Topazian HM, Gumbo A, Puerto-Meredith S, et al., 2020, Asymptomatic Plasmodium falciparum malaria prevalence among adolescents and adults in Malawi, 2015–2016, Scientific Reports, Vol:10, ISSN:2045-2322, Pages:18740-18740
Mitchell CL, Topazian HM, Brazeau NF, et al., 2020, Household prevalence of P. falciparum, P. vivax, and P. ovale in the Democratic Republic of the Congo, 2013-2014., Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Bell GJ, Loop M, Topazian HM, et al., 2020, Case reduction and cost-effectiveness of the RTS,S/AS01 malaria vaccine alongside bed nets in Lilongwe, Malawi., Vaccine, Vol:38, Pages:4079-4087
Topazian HM, Stoner MCD, Edwards JK, et al., 2020, Variations in HIV Risk by Young Women’s Age and Partner Age Disparity in Rural South Africa (HPTN 068)., Journal of Acquired Immune Deficiency Syndromes (1999), Vol:83, Pages:350-356