Imperial College London
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Dr Juliette Unwin

Faculty of Medicine, School of Public Health

Academic Visitor
 
 
 
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Contact

 

+44 (0)20 7594 3946h.unwin

 
 
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Location

 

UG1247 Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@techreport{Mishra:2021:10.25561/88876,
author = {Mishra, S and Mindermann, S and Sharma, M and Whittaker, C and Mellan, T and Wilton, T and Klapsa, D and Mate, R and Fritzsche, M and Zambon, M and Ahuja, J and Howes, A and Miscouridou, X and Nason, G and Ratmann, O and Leech, G and Fabienne, Sandkühler J and Rogers-Smith, C and Vollmer, M and Unwin, H and Gal, Y and Chand, M and Gandy, A and Martin, J and Volz, E and Ferguson, N and Bhatt, S and Brauner, J and Flaxman, S},
booktitle = {Report 44: Recent trends in SARS-CoV-2 variants of concern in England},
doi = {10.25561/88876},
publisher = {Imperial College London},
title = {Report 44: Recent trends in SARS-CoV-2 variants of concern in England},
url = {http://dx.doi.org/10.25561/88876},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - RPRT
AB  - Since its emergence in Autumn 2020, the SARS-CoV-2 Variant of Concern (VOC) B.1.1.7 rapidly became the dominant lineage across much of Europe. Simultaneously, several other VOCs were identified globally. Unlike B.1.1.7, some of these VOCs possess mutations thought to confer partial immune escape. Understanding when, whether, and how these additional VOCs pose a threat in settings where B.1.1.7 is currently dominant is vital. This is particularly true for England, which has high coverage from vaccines that are likely more protective against B.1.1.7 than some other VOCs. We examine trends in B.1.1.7’s prevalence in London and other English regions using passive-case detection PCR data, cross-sectional community infection surveys, genomic surveillance, and wastewater monitoring. Our results suggest shifts in the composition of SARS-CoV-2 lineages driving transmission in England between March and April 2021. Local transmission of non-B.1.1.7 VOCs may be increasing; this warrants urgent further investigation.
AU  - Mishra,S
AU  - Mindermann,S
AU  - Sharma,M
AU  - Whittaker,C
AU  - Mellan,T
AU  - Wilton,T
AU  - Klapsa,D
AU  - Mate,R
AU  - Fritzsche,M
AU  - Zambon,M
AU  - Ahuja,J
AU  - Howes,A
AU  - Miscouridou,X
AU  - Nason,G
AU  - Ratmann,O
AU  - Leech,G
AU  - Fabienne,Sandkühler J
AU  - Rogers-Smith,C
AU  - Vollmer,M
AU  - Unwin,H
AU  - Gal,Y
AU  - Chand,M
AU  - Gandy,A
AU  - Martin,J
AU  - Volz,E
AU  - Ferguson,N
AU  - Bhatt,S
AU  - Brauner,J
AU  - Flaxman,S
DO  - 10.25561/88876
PB  - Imperial College London
PY  - 2021///
TI  - Report 44: Recent trends in SARS-CoV-2 variants of concern in England
T1  - Report 44: Recent trends in SARS-CoV-2 variants of concern in England
UR  - http://dx.doi.org/10.25561/88876
UR  - https://www.imperial.ac.uk/media/imperial-college/medicine/mrc-gida/2021-05-20-COVID19-Report-44.pdf
UR  - http://hdl.handle.net/10044/1/88876
ER  -
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