Imperial College London
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Dr Juliette Unwin

Faculty of Medicine, School of Public Health

Academic Visitor
 
 
 
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Contact

 

+44 (0)20 7594 3946h.unwin

 
 
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Location

 

UG1247 Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Unwin:2021:10.1186/s12936-021-03966-x,
author = {Unwin, H and Mwandigha, L and Winskill, P and Ghani, A and Hogan, A},
doi = {10.1186/s12936-021-03966-x},
journal = {Malaria Journal},
pages = {1--11},
title = {Analysis of the potential for a malaria vaccine to reduce gaps in malaria intervention coverage},
url = {http://dx.doi.org/10.1186/s12936-021-03966-x},
volume = {20},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThe RTS,S/AS01 malaria vaccine is currently being evaluated in a cluster-randomized pilot implementation programme in three African countries. This study seeks to identify whether vaccination could reach additional children who are at risk from malaria but do not currently have access to, or use, core malaria interventions.MethodsUsing data from household surveys, the overlap between malaria intervention coverage and childhood vaccination (diphtheria-tetanus-pertussis dose 3, DTP3) uptake in 20 African countries with at least one first administrative level unit with Plasmodium falciparum parasite prevalence greater than 10% was calculated. Multilevel logistic regression was used to explore patterns of overlap by demographic and socioeconomic variables. The public health impact of delivering RTS,S/AS01 to those children who do not use an insecticide-treated net (ITN), but who received the DTP3 vaccine, was also estimated.ResultsUptake of DTP3 was higher than malaria intervention coverage in most countries. Overall, 34% of children did not use ITNs and received DTP3, while 35% of children used ITNs and received DTP3, although this breakdown varied by country. It was estimated that there are 33 million children in these 20 countries who do not use an ITN. Of these, 23 million (70%) received the DTP3 vaccine. Vaccinating those 23 million children who receive DTP3 but do not use an ITN could avert up to an estimated 9.7 million (range 8.5–10.8 million) clinical malaria cases each year, assuming all children who receive DTP3 are administered all four RTS,S doses. An additional 10.8 million (9.5–12.0 million) cases could be averted by vaccinating those 24 million children who receive the DTP3 vaccine and use an ITN. Children who had access to or used an ITN were 9–13% more likely to reside in rural areas compared to those who had neither intervention regardless of vaccination status. Mothers’ education status was a strong predictor of inte
AU  - Unwin,H
AU  - Mwandigha,L
AU  - Winskill,P
AU  - Ghani,A
AU  - Hogan,A
DO  - 10.1186/s12936-021-03966-x
EP  - 11
PY  - 2021///
SN  - 1475-2875
SP  - 1
TI  - Analysis of the potential for a malaria vaccine to reduce gaps in malaria intervention coverage
T2  - Malaria Journal
UR  - http://dx.doi.org/10.1186/s12936-021-03966-x
UR  - https://malariajournal.biomedcentral.com/articles/10.1186/s12936-021-03966-x
UR  - http://hdl.handle.net/10044/1/92788
VL  - 20
ER  -
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