Imperial College London
Portrait Picture

DrHelenWalkey

Central Faculty, Education Office

Learning Analytics Product Manager
 
 
 
//

Contact

 

h.walkey Website

 
 
//

Location

 

Sherfield BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Walkey:2018:10.1136/bmjopen-2017-020904,
author = {Walkey, HC and Bravis, V and Akaal, K and Godsland, I and Misra, S and Williams, AJK and Bingley, PJ and Dunger, DB and Dayan, CM and Peakman, M and Oliver, N and Johnston, D},
doi = {10.1136/bmjopen-2017-020904},
journal = {BMJ Open},
title = {The relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort},
url = {http://dx.doi.org/10.1136/bmjopen-2017-020904},
volume = {8},
year = {2018}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives:Todescribethecharacteristicsofchildrenandadultswithincidenttype1diabetesincontemporary,multi-ethnicUK,focusingondifferencesbetweentheisletautoantibodynegativeandpositive.Design:Observationalcohortstudy.Setting:146mainlysecondarycarecentresacrossEnglandandWales.Participants:3,312peopleaged≥5yearswererecruitedwithin6monthsofaclinicaldiagnosisoftype1diabetesviatheNationalInstituteforHealthResearchClinicalResearchNetwork.3,021wereofwhiteEuropeanethnicityand291(9%)werenon-white.Therewasasmallmalepredominance(57%).Youngpeople<17yearscomprised59%.Mainoutcomemeasures:Autoantibodystatusandcharacteristicsatpresentation.Results:Themajoritypresentedwithclassicalosmoticsymptoms,weightloss,andfatigue.Ketoacidosiswascommon(42%),especiallyinadults,andirrespectiveofethnicity.35%wereoverweightorobese.Ofthe1,778participantswhodonatedabloodsample,85%werepositiveforoneormoreautoantibodiesagainstglutamatedecarboxylase,isletantigen-2,andzinctransporter8.Presentingsymptomsweresimilarintheautoantibodypositiveandnegativeparticipants,aswasthefrequencyofketoacidosis(43%vs40%,p=0·3).Autoantibodypositivitywaslesscommonwithincreasingage(p=0·0001),inmalescomparedwithfemales(82%vs90%,p<0·0001)andinpeopleofnon-whitecomparedwithwhiteethnicity(73%vs86%,p<0·0001).Bodymassindexwashigherinautoantibodynegativethanpositiveadults(median,IQR25·5,23·1-29·2vs23·9,21·4-26·7kg/m2;p=0·0001).Autoantibodynegativeparticipants weremorelikelytohaveaparentwithdiabetes(28%vs16%,p<0·0001)andlesslikelytohaveanotherautoimmunedisease(4%vs8%,p=0.01).Conclusions:Mostpeopleassignedadiagnosisoftype1diabetespresentedwithclassicalclinicalfeaturesandisletautoantibodies.Althoughindistinguishableatanindividuallevel,autoantibodynegativeparticipantsasagroupdemonstratedfeaturesmoretypicallyassociatedwithotherdiabetessubtypes.
AU  - Walkey,HC
AU  - Bravis,V
AU  - Akaal,K
AU  - Godsland,I
AU  - Misra,S
AU  - Williams,AJK
AU  - Bingley,PJ
AU  - Dunger,DB
AU  - Dayan,CM
AU  - Peakman,M
AU  - Oliver,N
AU  - Johnston,D
DO  - 10.1136/bmjopen-2017-020904
PY  - 2018///
SN  - 2044-6055
TI  - The relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2017-020904
UR  - http://hdl.handle.net/10044/1/57821
VL  - 8
ER  -
Download