Imperial College London

ProfessorHelenWard

Faculty of MedicineSchool of Public Health

Professor of Public Health
 
 
 
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Contact

 

+44 (0)20 7594 3303h.ward Website

 
 
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Location

 

158Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Davies:2016:10.1016/S1473-3099(16)30092-5,
author = {Davies, B and Turner, K and Frolund, M and Ward, H and May, M and Rasmussen, S and Benfield, T and Westh, H and Danish, Chlamydia Study Group},
doi = {10.1016/S1473-3099(16)30092-5},
journal = {Lancet Infectious Diseases},
pages = {1057--1064},
title = {Risk of reproductive complications following chlamydia testing: a population-based retrospective cohort study in Denmark},
url = {http://dx.doi.org/10.1016/S1473-3099(16)30092-5},
volume = {16},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Background: Uncertainty in the risk of reproductive complications (pelvic inflammatory disease (PID), ectopic pregnancy (EP) and tubal factor infertility (TFI)) following chlamydia infection and repeat infection hampers the design of evidence-based chlamydia control programmes. We estimate the association between diagnosed chlamydia and episodes of hospital healthcare (in-patient, out-patient and emergency department) for a reproductive complication.Methods: We constructed and analysed a retrospective population-based cohort of women aged 15-44 years from administrative records in Denmark (1995-2012). Findings: The 516,720 women (103,344 positive, 182,879 negative, 230,497 never-tested) had a mean follow-up of 7.96 years. Compared to women with only negative tests, the risk of each complication was 30% higher in women with ≥1 positive test (adjusted hazard ratios (AHRs) PID 1·50(1·43-1·57); EP 1·31(1·25-1·38); TFI 1·37(1·24-1·52)) and 60% lower in women who were never-tested (AHRs PID 0·33(0·31-0·35); EP 0·42(0·39-0·44); TFI 0·29(0·25-0·33)). A positive test had a minor absolute impact on health as the difference in the lifetime incidence of complications was small between women who tested positive and those who tested negative (PID 0.6%; EP 0.2%; TFI 0·1%). Repeat infections increased the risk of PID by a further 20% (AHR 1·20(1·11-1·31)). Interpretation: A single diagnosed chlamydia infection increased the risk of all complications and a repeat diagnosed infection further increased the risk of PID. Therefore control programmes must prevent first and repeat infections to improve women’s reproductive health.
AU - Davies,B
AU - Turner,K
AU - Frolund,M
AU - Ward,H
AU - May,M
AU - Rasmussen,S
AU - Benfield,T
AU - Westh,H
AU - Danish,Chlamydia Study Group
DO - 10.1016/S1473-3099(16)30092-5
EP - 1064
PY - 2016///
SN - 1473-3099
SP - 1057
TI - Risk of reproductive complications following chlamydia testing: a population-based retrospective cohort study in Denmark
T2 - Lancet Infectious Diseases
UR - http://dx.doi.org/10.1016/S1473-3099(16)30092-5
UR - http://hdl.handle.net/10044/1/32367
VL - 16
ER -