Imperial College London

ProfessorHelenWard

Faculty of MedicineSchool of Public Health

Professor of Public Health
 
 
 
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Contact

 

+44 (0)20 7594 3303h.ward Website

 
 
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Location

 

158Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@misc{Davies:2017,
author = {Davies, B and Turner, KME and Andersen, B and Westh, H and Ward, H},
title = {P3.25Quantification of the risk of pelvic inflammatory disease following a chlamydia trachomatis test by diagnostic test type},
type = {Poster},
url = {http://dx.doi.org/10.1136/sextrans-2017-053264.262},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - GEN
AB - Introduction Nucleic Acid Amplification Tests (NAATs) are the recommended test type for diagnosing Chlamydia trachomatis (chlamydia). However poorer performing methods remain in use. We compared the risk of pelvic inflammatory disease (PID) in women tested for chlamydia by diagnostic test type.Methods We used a sub-set of the Danish Chlamydia study that included all female residents of Denmark who were tested for chlamydia (1998–2001) when aged 15–34 years. Chlamydia tests performed on urinary or genital samples with a definitive positive or negative result were categorised as non-NAAT (ELISA; IF; “antigen”) or NAAT (PCR; SDA; TMA; LCR; DNA/RNA) and limited to each woman’s first test. Test records were linked to hospital presentations for PID within 12 months. Women with previous PID or PID diagnosed on the same date as the test were excluded. We used logistic regression to compare the risk of PID by test type adjusted for age, test year and test result.Results Of the 2 72 105 women in the study, 44.78% were tested using NAAT, 6.38% tested positive for chlamydia and 0.64% were diagnosed with PID within 12 months. Overall, the adjusted risk of PID within 12 months of a chlamydia test was higher following a positive test (AOR 1.40 (95%CI 1.18–1.67) and in older women (25–34 years 1.36 (1.23–1.49)) and lower in women tested using a NAAT (0.87 (0.78–0.96)) and in the more recent time interval (2000/2001 0.89 (0.80–0.99)). In women with a positive test, and presumably treated infection, the risk of PID did not differ by test type (1.25 (0.87–1.79)). In women with a negative test, the risk of PID was lower following a NAAT (0.84 (0.75–0.93)).Conclusion Women with a negative result from a non-NAAT chlamydia test have a 16% higher risk of PID by 12 months compared to women with a negative result from a NAAT. This is presumably due to the increased proportion of false negative tests with th
AU - Davies,B
AU - Turner,KME
AU - Andersen,B
AU - Westh,H
AU - Ward,H
PY - 2017///
TI - P3.25Quantification of the risk of pelvic inflammatory disease following a chlamydia trachomatis test by diagnostic test type
UR - http://dx.doi.org/10.1136/sextrans-2017-053264.262
UR - http://hdl.handle.net/10044/1/71203
ER -