Imperial College London
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ProfessorHelenWard

Faculty of Medicine, School of Public Health

Professor of Public Health
 
 
 
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Contact

 

+44 (0)20 7594 3303h.ward Website

 
 
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Location

 

311School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Ward:2021,
author = {Ward, H and Cooke, G and Whitaker, M and Redd, R and Eales, O and Brown, J and Collet, K and Cooper, E and Daunt, A and Jones, K and Moshe, M and Willicombe, M and Day, S and Atchison, C and Darzi, A and Donnelly, C and Riley, S and Ashby, D and Barclay, W and Elliott, P},
title = {REACT-2 Round 5: increasing prevalence of SARS-CoV-2 antibodies demonstrate impact of the second wave and of vaccine roll-out in England},
url = {http://hdl.handle.net/10044/1/86241},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - BackgroundEngland has experienced high rates of SARS-CoV-2 infection during the COVID-19 pandemic, affecting in particular minority ethnic groups and more deprived communities. A vaccination programme began in England in December 2020, with priority given to administering thefirst dose to the largest number of older individuals, healthcare and care home workers.MethodsA cross-sectional community survey in England undertaken between 26 January and 8 February 2021 as the fifth round of the REal-time Assessment of Community Transmission-2 (REACT-2) programme. Participants completed questionnaires, including demographic details and clinical and COVID-19 vaccination histories, and self-administered a lateral flowimmunoassay (LFIA) test to detect IgG against SARS-CoV-2 spike protein. There were sufficient numbers of participants to analyse antibody positivity after 21 days from vaccination with the PfizerBioNTech but not the AstraZeneca/Oxford vaccine which was introduced slightly later.ResultsThe survey comprised 172,099 people, with valid IgG antibody results from 155,172. The overall prevalence of antibodies (weighted to be representative of the population of England and adjusted for test sensitivity and specificity) in England was 13.9% (95% CI 13.7, 14.1) overall, 37.9% (37.2, 38.7) in vaccinated and 9.8% (9.6, 10.0) in unvaccinated people.The prevalence of antibodies (weighted) in unvaccinated people was highest in London at 16.9% (16.3, 17.5), and higher in people of Black (22.4%, 20.8, 24.1) and Asian (20.0%, 19.0, 21.0) ethnicity compared to white (8.5%, 8.3, 8.7) people. The uptake of vaccination by age was highest in those aged 80 years or older (93.5%). Vaccine confidence was high with 92.0% (91.9, 92.1) of people saying that they had accepted or intended to accept the offer.Vaccine confidence varied by age and ethnicity, with lower confidence in young people and those of Black ethnicity. Particular concerns were identified around pregnancy, fertility and alle
AU  - Ward,H
AU  - Cooke,G
AU  - Whitaker,M
AU  - Redd,R
AU  - Eales,O
AU  - Brown,J
AU  - Collet,K
AU  - Cooper,E
AU  - Daunt,A
AU  - Jones,K
AU  - Moshe,M
AU  - Willicombe,M
AU  - Day,S
AU  - Atchison,C
AU  - Darzi,A
AU  - Donnelly,C
AU  - Riley,S
AU  - Ashby,D
AU  - Barclay,W
AU  - Elliott,P
PY  - 2021///
TI  - REACT-2 Round 5: increasing prevalence of SARS-CoV-2 antibodies demonstrate impact of the second wave and of vaccine roll-out in England
UR  - http://hdl.handle.net/10044/1/86241
ER  -
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