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@unpublished{Riley:2021,
author = {Riley, S and Haw, D and Walters, C and Wang, H and Eales, O and Ainslie, K and Atchison, C and Fronterre, C and Diggle, P and Page, A and Trotter, A and Viet, TL and Nabil-Fareed, A and O'Grady, J and The, COVID-19 Genomics UK Consortium and Ashby, D and Donnelly, C and Cooke, G and Barclay, W and Ward, H and Darzi, A and Elliott, P},
title = {REACT-1 round 11 report: low prevalence of SARS-CoV-2 infection in the community prior to the third step of the English roadmap out of lockdown},
url = {http://hdl.handle.net/10044/1/88507},
year = {2021}
}

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TY  - UNPB
AB  - BackgroundNational epidemic dynamics of SARS-CoV-2 infections are being driven by: the degree of recent indoor mixing (both social and workplace), vaccine coverage, intrinsic properties of the circulating lineages, and prior history of infection (via natural immunity). In England, infections, hospitalisations and deaths fell during the first two steps of the “roadmap” for exiting the third national lockdown. The third step of the roadmap in England takes place on 17 May 2021.MethodsWe report the most recent findings on community infections from the REal-time Assessment of Community Transmission-1 (REACT-1) study in which a swab is obtained from a representative cross-sectional sample of the population in England and tested using PCR. Round 11 of REACT-1 commenced self-administered swab-collection on 15 April 2021 and completed collections on 3 May 2021. We compare the results of REACT-1 round 11 to round 10, in which swabs were collected from 11 to 30 March 2021.ResultsBetween rounds 10 and 11, prevalence of swab-positivity dropped by 50% in England from 0.20% (0.17%, 0.23%) to 0.10% (0.08%, 0.13%), with a corresponding R estimate of 0.90 (0.87, 0.94). Rates of swab-positivity fell in the 55 to 64 year old group from 0.17% (0.12%, 0.25%) in round 10 to 0.06% (0.04%, 0.11%) in round 11. Prevalence in round 11 was higher in the 25 to 34 year old group at 0.21% (0.12%, 0.38%) than in the 55 to 64 year olds and also higher in participants of Asian ethnicity at 0.31% (0.16%, 0.60%) compared with white participants at 0.09% (0.07%, 0.11%). Based on sequence data for positive samples for which a lineage could be identified, we estimate that 92.3% (75.9%, 97.9%, n=24) of infections were from the B.1.1.7 lineage compared to 7.7% (2.1%, 24.1%, n=2) from the B.1.617.2 lineage. Both samples from the B.1.617.2 lineage were detected in London from participants not reporting travel in the previous two weeks. Also, allowing for suitable lag periods, the prior close alig
AU  - Riley,S
AU  - Haw,D
AU  - Walters,C
AU  - Wang,H
AU  - Eales,O
AU  - Ainslie,K
AU  - Atchison,C
AU  - Fronterre,C
AU  - Diggle,P
AU  - Page,A
AU  - Trotter,A
AU  - Viet,TL
AU  - Nabil-Fareed,A
AU  - O'Grady,J
AU  - The,COVID-19 Genomics UK Consortium
AU  - Ashby,D
AU  - Donnelly,C
AU  - Cooke,G
AU  - Barclay,W
AU  - Ward,H
AU  - Darzi,A
AU  - Elliott,P
PY  - 2021///
TI  - REACT-1 round 11 report: low prevalence of SARS-CoV-2 infection in the community prior to the third step of the English roadmap out of lockdown
UR  - http://hdl.handle.net/10044/1/88507
ER  -

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