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@unpublished{Whitaker:2021,
author = {Whitaker, M and Elliott, J and Chadeau-Hyam, M and Riley, S and Darzi, A and Cooke, G and Ward, H and Elliott, P},
title = {Persistent symptoms following SARS-CoV-2 infection in a random community sample of 508,707 people},
url = {http://hdl.handle.net/10044/1/89844},
year = {2021}
}

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TY  - UNPB
AB  - IntroductionLong COVID, describing the long-term sequelae after SARS-CoV-2 infection, remains a poorlydefined syndrome. There is uncertainty about its predisposing factors and the extent of theresultant public health burden, with estimates of prevalence and duration varying widely.MethodsWithin rounds 3–5 of the REACT-2 study, 508,707 people in the community in England wereasked about a prior history of COVID-19 and the presence and duration of 29 differentsymptoms. We used uni- and multivariable models to identify predictors of persistence ofsymptoms (12 weeks or more). We estimated the prevalence of symptom persistence at 12weeks, and used unsupervised learning to cluster individuals by symptoms experienced.ResultsAmong the 508,707 participants, the weighted prevalence of self-reported COVID-19 was 19.2%(95% CI: 19.1,19.3). 37.7% of 76,155 symptomatic people post COVID-19 experienced at leastone symptom, while 14.8% experienced three or more symptoms, lasting 12 weeks or more. Thisgives a weighted population prevalence of persistent symptoms of 5.75% (5.68, 5.81) for one and2.22% (2.1, 2.26) for three or more symptoms. Almost a third of people 8,771/28,713 (30.5%)with at least one symptom lasting 12 weeks or more reported having had severe COVID-19symptoms (“significant effect on my daily life”) at the time of their illness, giving a weightedprevalence overall for this group of 1.72% (1.69,1.76). The prevalence of persistent symptomswas higher in women than men (OR: 1.51 [1.46,1.55]) and, conditional on reporting symptoms,risk of persistent symptoms increased linearly with age by 3.5 percentage points per decade oflife. Obesity, smoking or vaping, hospitalisation , and deprivation were also associated with ahigher probability of persistent symptoms, while Asian ethnicity was associated with a lowerprobability. Two stable clusters were identified based on symptoms that persisted for 12 weeks ormore: in the largest cluster, tiredness predominated
AU  - Whitaker,M
AU  - Elliott,J
AU  - Chadeau-Hyam,M
AU  - Riley,S
AU  - Darzi,A
AU  - Cooke,G
AU  - Ward,H
AU  - Elliott,P
PY  - 2021///
TI  - Persistent symptoms following SARS-CoV-2 infection in a random community sample of 508,707 people
UR  - http://hdl.handle.net/10044/1/89844
ER  -

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