Publications
121 results found
Hankin J, Xuan W, Zhao H, et al., 2014, Effects of local anaesthetics on cancer cell death <i>in vitro</i>: a comparative study, Spring Meeting of the Anaesthetic-Research-Society, Publisher: ELSEVIER SCI LTD, Pages: 319-319, ISSN: 0007-0912
Zhao Y, Zhao H, Lobo N, et al., 2014, Celastrol Enhances Cell Viability and Inhibits Amyloid-beta Production Induced by Lipopolysaccharide In Vitro, JOURNAL OF ALZHEIMERS DISEASE, Vol: 41, Pages: 835-844, ISSN: 1387-2877
Zhao H, Iwasaki M, Yang J, et al., 2014, Hypoxia-inducible factor-1: a possible link between inhalational anesthetics and tumor progression?, Acta Anaesthesiol Taiwan, Vol: 52, Pages: 70-76
Cancer remains one of the major causes of death worldwide, and the global burden of the disease is rising continuously. Clinical retrospective data suggested that inhalational anesthetics might affect the prognosis of cancer patients, but the underlying molecular mechanism remained unknown. Hypoxia-inducible factor-1 (HIF-1) is a dimeric transcription factor and mediates various cellular responses to hypoxia, including metabolism, cell death and survival, angiogenesis, oxygen delivery, immune evasion, and genomic adaptation. HIF-1 system has been shown to be the driving force of solid tumor progression and substantially contributes to the malignancy of cancer. Inhalational anesthetics such as isoflurane have been demonstrated to confer cytoprotection in a HIF-1-dependent manner in various vital organs. In addition, a recent study has demonstrated the pivotal involvement of HIF-1 in the impact of inhalational anesthetics on cancer cells. This review provides critical insights into the new understanding of cancer sensing of inhalational anesthetics and examines the recent understanding of the underlying molecular mechanisms. However, this area of research is just beginning and warrants further studies preclinically and clinically prior to making any conclusions that inhalational anesthetics may affect cancer outcomes. In addition, it is important to note that there is not enough evidence to support any change in the current clinical practice.
Zhao H, Perez JS, Lu K, et al., 2014, Role of Toll-like receptor-4 in renal graft ischemia-reperfusion injury, AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, Vol: 306, Pages: F801-F811, ISSN: 1931-857X
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- Citations: 90
Ning J, Mo L, Zhao H, et al., 2014, Transient Regional Hypothermia Applied to a Traumatic Limb Attenuates Distant Lung Injury Following Blast Limb Trauma, CRITICAL CARE MEDICINE, Vol: 42, Pages: E68-E78, ISSN: 0090-3493
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- Citations: 12
Zhao H, Luo X, Zhou Z, et al., 2014, Early treatment with xenon protects against the cold ischemia associated with chronic allograft nephropathy in rats, KIDNEY INTERNATIONAL, Vol: 85, Pages: 112-123, ISSN: 0085-2538
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- Citations: 25
Zhao Y, Zhao H, Lobo N, et al., 2014, Celastrol Enhances Cell Viability and Inhibits Amyloid-β Production Induced by Lipopolysaccharide In Vitro, J Alzheimers Dis
Yang B, Kang H, Fung A, et al., 2014, The Role of Interleukin 17 in Tumour Proliferation, Angiogenesis, and Metastasis, MEDIATORS OF INFLAMMATION, Vol: 2014, ISSN: 0962-9351
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- Citations: 114
Zhao H, Huang H, Ma D, 2014, Remote lung injury after renal graft ischaemia-reperfusion injury in rats, Winter Meeting of the Anaesthetic-Research-Society (ARS), Publisher: OXFORD UNIV PRESS, Pages: 185P-185P, ISSN: 0007-0912
Mitchell S, Zhao H, Ma D, 2014, Mechanistic profile of argon neuroprotection vs injury in vitro, Winter Meeting of the Anaesthetic-Research-Society (ARS), Publisher: OXFORD UNIV PRESS, Pages: 192P-193P, ISSN: 0007-0912
Xuan W, Zhao H, Hankin J, 2014, Bupivacaine induces ovarian cancer cell death via caspase 8 modulation, Publisher: OXFORD UNIV PRESS, Pages: 319-320, ISSN: 0007-0912
Zhao H, Ning J, Savage S, et al., 2013, A novel strategy for preserving renal grafts in an <i>ex vivo</i> setting: potential for enhancing the marginal donor pool, FASEB JOURNAL, Vol: 27, Pages: 4822-4833, ISSN: 0892-6638
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- Citations: 12
Zhao H, Yoshida A, Xiao W, et al., 2013, Xenon treatment attenuates early renal allograft injury associated with prolonged hypothermic storage in rats, FASEB JOURNAL, Vol: 27, Pages: 4076-4088, ISSN: 0892-6638
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- Citations: 27
Zhao H, Watts HR, Chong M, et al., 2013, Xenon Treatment Protects Against Cold Ischemia Associated Delayed Graft Function and Prolongs Graft Survival in Rats, AMERICAN JOURNAL OF TRANSPLANTATION, Vol: 13, Pages: 2006-2018, ISSN: 1600-6135
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- Citations: 44
Zhao H, Cui TY, Ma D, 2013, Argon combined with hypothermia protects against hypoxia-ischaemia-induced brain damage in rat neonates, Meeting of the Anaesthetic-Research-Society, Publisher: OXFORD UNIV PRESS, Pages: 877-877, ISSN: 0007-0912
Ning J, Mo L, Zhao H, et al., 2013, Sodium Hydrosulphide Alleviates Remote Lung Injury Following Limb Traumatic Injury in Rats, PLOS ONE, Vol: 8, ISSN: 1932-6203
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- Citations: 18
Zheng X, Zhao H, Sooranna SR, et al., 2013, Development of a Clinically Relevant Model of Perinatal Hypoxic Ischaemic Encephalopathy in Mice., 60th Annual Scientific Meeting of the Society-for-Gynecologic-Investigation (SGI), Publisher: SAGE PUBLICATIONS INC, Pages: 300A-300A, ISSN: 1933-7191
Asavarut P, Zhao H, Gu J, et al., 2013, The role of HMGB1 in inflammation-mediated organ injury., Acta Anaesthesiol Taiwan, Vol: 51, Pages: 28-33
HMGB1 is a chromosome-binding protein that also acts as a damage-associated molecular pattern molecule. It has potent proinflammatory effects and is one of key mediators of organ injury. Evidence from research has revealed its involvement in the signaling mechanisms of Toll-like receptors and the receptor for advanced glycation end-products in organ injury. HMGB1-mediated organ injuries are acute damage including ischemic, mechanical, allograft rejection and toxicity, and chronic diseases of the heart, kidneys, lungs, and brain. Strategies against HMGB1 and its associated cellular signal pathways need to be developed and may have preventive and therapeutic potentials in organ injury.
Zhao H, Luo X, Ahmed A, et al., 2013, Effects of intravenous anaesthetic propofol on ovarian cancer cell proliferation, migration and chemo-sensitivity, NCRI cancer conference
Zhao H, Cui TY, Ma D, 2013, Argon combined with hypothermia protects against hypoxia-ischaemia-induced brain damage in rat neonates, Meeting of the Anaesthetic-Research-Society, Pages: 877-877, ISSN: 0007-0912
Ning J, Mo L, Lai X, et al., 2012, Sodium hydrosulphide alleviates remote lung injury after blast limb trauma, Meeting of the Anaesthetic-Research-Society, Pages: 659-660
Luo X, Hennah L, Zhao H, et al., 2012, Isoflurane enhances the proliferation and angiogenesis of ovarian cancer cells, Meeting of the Anaesthetic-Research-Society, Pages: 668-668
Luo X, Hennah L, Zhao H, et al., 2012, Isoflurane enhances the proliferation and angiogenesis of ovarian cancer cells, Meeting of the Anaesthetic-Research-Society, Publisher: OXFORD UNIV PRESS, Pages: 668P-668P, ISSN: 0007-0912
Ning J, Mo L, Lai X, et al., 2012, Sodium hydrosulphide alleviates remote lung injury after blast limb trauma, Meeting of the Anaesthetic-Research-Society, Publisher: OXFORD UNIV PRESS, Pages: 659P-660P, ISSN: 0007-0912
Zhuang L, Yang T, Zhao H, et al., 2012, The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats, CRITICAL CARE MEDICINE, Vol: 40, Pages: 1724-1730, ISSN: 0090-3493
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- Citations: 104
Ma D, Huang H, Zhao H, 2012, Remote Pulmonary Inflammation Following Renal Graft Engraftment In Rats, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB162-AB162, ISSN: 0091-6749
Gu J, Chen J, Xia P, et al., 2011, Dexmedetomidine attenuates remote lung injury induced by renal ischemia-reperfusion in mice, ACTA ANAESTHESIOLOGICA SCANDINAVICA, Vol: 55, Pages: 1272-1278, ISSN: 0001-5172
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- Citations: 127
Zhao H, Ma D, 2011, Xenon preconditioning protects renal graft against ischaemia-reperfusion injury in rats, Annual Meeting of the Anaesthetic-Research-Society, Publisher: OXFORD UNIV PRESS, Pages: 445P-446P, ISSN: 0007-0912
Gu J, Sun P, Zhao H, et al., 2011, Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice, CRITICAL CARE, Vol: 15, ISSN: 1466-609X
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- Citations: 204
Zhang L, Huang H, Cheng J, et al., 2011, Pre-treatment with isoflurane ameliorates renal ischemic–reperfusion injury in mice, Life Sciences, Vol: 88, Pages: 1102 - 1107-1102 - 1107, ISSN: 0024-3205
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