Imperial College London

DrHannahMaude

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Research Associate
 
 
 
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Contact

 

hannah.maude12

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Summary

I am currently an active researcher in the Regulatory Genomics and Metabolic Disease group, researching the functional genomics landscape of the liver under conditions of hyperlipidemia and hyperglycemia.

As a Fellow of the Higher Education Academy, I deliver regular teaching and tutoring on several MSc courses, including Human Molecular Genetics and Applied Genomics. I specialise in bioinformatics, including the analysis of whole-genome, whole-exome and targeted sequence data, as well as RNA-seq, ATAC-seq and ChIP-seq data (see the Cebola Lab RNA-seq and ATAC-seq online tutorials).

I completed my PhD in 2019, titled 'the role of mitochondrial dysfunction in the onset of Type 2 Diabetes', carried out with Dr Toby Andrew at Imperial College. My interests cover complex and rare diseases, including the heritability of metabolic pathways and insulin resistance, mitochondrial diseases and non-alcoholic fatty liver disease. In particular, I study the roles of rare variants and non-coding, functional mutations in causing disease, including undiagnosed cases of mitochondrial disease registered in the 100,000 Genomics Project.

In my spare time, I love to read popular science novels (and dream of writing my own!), paint, and play video games. For thoughts, discussions and general conversation, drop a message via my twitter


Publications

Journals

Maude H, Lau W, Maniatis N, et al., 2021, New Insights Into Mitochondrial Dysfunction at Disease Susceptibility Loci in the Development of Type 2 Diabetes, Frontiers in Endocrinology, Vol:12, ISSN:1664-2392

Maude H, Sanchez Cabanillas C, Cebola I, 2021, Epigenetics of hepatic insulin resistance, Frontiers in Endocrinology, Vol:12, ISSN:1664-2392, Pages:1-24

Maude H, Davidson M, Charitakis N, et al., 2019, NUMT confounding biases mitochondrial heteroplasmy calls in favor of the reference allele, Frontiers in Cell and Developmental Biology, Vol:7, ISSN:2296-634X

Dalmia A, Dib M-J, Maude H, et al., 2019, A genetic epidemiological study in British adults and older adults shows a high heritability of the combined indicator of vitamin B12 status (cB12) and connects B12 status with utilization of mitochondrial substrates and energy metabolism, The Journal of Nutritional Biochemistry, Vol:70, ISSN:0955-2863, Pages:156-163

Coelho MB, Ascher DB, Gooding C, et al., 2016, Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins, Biochemical Society Transactions, Vol:44, ISSN:0300-5127, Pages:1058-1065

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