Summary
I am currently a postdoctoral Research Associate in the Regulatory Genomics and Metabolic Disease group, researching the functional genomics landscape of the liver under conditions of hyperlipidemia and hyperglycemia.
I specialise in bioinformatics, including the analysis of whole-genome, whole-exome and targeted sequence data, as well as RNA-seq, ATAC-seq and ChIP-seq data (see the Cebola Lab RNA-seq and ATAC-seq online tutorials).
I completed my PhD in 2019, titled 'the role of mitochondrial dysfunction in the onset of Type 2 Diabetes', carried out with Dr Toby Andrew at Imperial College. My interests cover complex and rare diseases, including the heritability of metabolic pathways and insulin resistance, mitochondrial diseases and non-alcoholic fatty liver disease. In particular, I study the roles of rare variants and non-coding, functional mutations in causing disease, including undiagnosed cases of mitochondrial disease registered in the 100,000 Genomics Project.
Professional affiliations: Genetics Society Local Ambassador Imperial College (White City) and Society for Endocrinology Media Ambassador (see examples quotes in The Guardian and The Times).
Teaching: As a Fellow of the Higher Education Academy, I deliver regular teaching and tutoring on several MSc courses, including Human Molecular Genetics and Applied Genomics.
Science Communication: I host the DNA& podcast funded by the UK Genetics Society and regularly participate in science engagement, including at the Great Exhibition Road festival and Imperial Lates. Expert quotes provided as a SfE Media Ambassador can be seen in the Guardian, Times, Telegraph, Insider and Evening Standard.
In my spare time, I love to read popular science novels (and dream of writing my own!), paint, and play video games. For thoughts, discussions and general conversation, drop a message via my twitter!
Publications
Journals
Jobbins AM, Yu S, Paterson HAB, et al., 2023, Pre-RNA splicing in metabolic homeostasis and liver disease, Trends in Endocrinology and Metabolism, Vol:34, ISSN:1043-2760, Pages:823-837
Nagy D, Maude H, Birdsey GM, et al., 2023, Liver sinusoidal endothelial transcription factors in metabolic homeostasis and disease, Journal of Molecular Endocrinology, Vol:71, ISSN:0952-5041, Pages:1-20
Maude H, Cebola I, 2023, Zooming into process-specific risk., Nature Metabolism, Vol:5, ISSN:2522-5812, Pages:730-731
Dixon PH, Levine AP, Cebola I, et al., 2022, GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements, Nature Communications, Vol:13, ISSN:2041-1723
Maude H, Lau W, Maniatis N, et al., 2021, New Insights Into Mitochondrial Dysfunction at Disease Susceptibility Loci in the Development of Type 2 Diabetes, Frontiers in Endocrinology, Vol:12, ISSN:1664-2392