Imperial College London
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Professor Hashim Ahmed

Faculty of Medicine, Department of Surgery & Cancer

Chair in Urology (Clinical)
 
 
 
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Contact

 

hashim.ahmed

 
 
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Location

 

5L28Lab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bass:2022:10.1038/s41391-021-00449-7,
author = {Bass, E and Pantovic, A and Connor, M and Loeb, S and Rastinehad, A and Winkler, M and Gabe, R and Ahmed, H},
doi = {10.1038/s41391-021-00449-7},
journal = {Prostate Cancer and Prostatic Diseases},
pages = {174--179},
title = {Diagnostic accuracy of magnetic resonance imaging targeted biopsy techniques compared to transrectal ultrasound guided biopsy of the prostate: a systematic review and meta-analysis},
url = {http://dx.doi.org/10.1038/s41391-021-00449-7},
volume = {25},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND Multiparametric MRI localizes cancer in the prostate, allowing for MRI guided biopsy (MRI-GB) 43 alongside transrectal ultrasound guided systematic biopsy (TRUS-GB). Three MRI-GB approaches exist; visual estimation (COG-TB); fusion software-assisted (FUS-TB) and MRI ‘in-bore’ biopsy (IB-TB). It is unknown whether any of these are superior. We conducted a systematic review and meta-analysis to address 3 questions. First, whether MRI-GB is superior to TRUS-GB at detecting clinically significant PCa (csPCa). Second, whether MRI-GB is superior to TRUS-GB at avoiding detection of insignificant PCa. Third, whether any MRI-GB strategy is superior at detecting csPCa.METHODS A systematic literature review from 2015 to 2019 was performed in accordance with the START recommendations. Studies reporting PCa detection rates, employing MRI-GB and TRUS-GB were included and evaluated using the QUADAS-2 checklist. 1553 studies were found, of which 43 were included in the meta-analysis. RESULTS For csPCa, MRI-GB was superior in detection to TRUS-GB (0.83 vs. 0.63 [p=0.02]). MRI-GB was superior in detection to TRUS-GB at avoiding detection of insignificant PCa. No MRI-GB technique was superior at detecting csPCa (IB-TB 0.87; COG TB 0.81; FUS-TB 0.81,[p=0.55]). There was significant heterogeneity observed between the included studies. CONCLUSIONS In patients with suspected PCa on MRI, MRI-GB offers superior rates of csPCa detection and reduces detection of insignificant PCa compared to TRUS-GB. No individual MRI-GB technique was found to be better in csPCa detection. Prospective adequately powered randomized controlled trials are required.
AU  - Bass,E
AU  - Pantovic,A
AU  - Connor,M
AU  - Loeb,S
AU  - Rastinehad,A
AU  - Winkler,M
AU  - Gabe,R
AU  - Ahmed,H
DO  - 10.1038/s41391-021-00449-7
EP  - 179
PY  - 2022///
SN  - 1365-7852
SP  - 174
TI  - Diagnostic accuracy of magnetic resonance imaging targeted biopsy techniques compared to transrectal ultrasound guided biopsy of the prostate: a systematic review and meta-analysis
T2  - Prostate Cancer and Prostatic Diseases
UR  - http://dx.doi.org/10.1038/s41391-021-00449-7
UR  - https://www.nature.com/articles/s41391-021-00449-7
UR  - http://hdl.handle.net/10044/1/91462
VL  - 25
ER  -
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