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@article{Grey:2022:10.1016/S1470-2045(22)00016-X,
author = {Grey, ADR and Scott, R and Shah, B and Acher, P and Liyanage, S and Pavlou, M and Omar, R and Chinegwundoh, F and Patki, P and Shah, TT and Hamid, S and Ghei, M and Gilbert, K and Campbell, D and Brew-Graves, C and Arumainayagam, N and Chapman, A and McLeavy, L and Karatziou, A and Alsaadi, Z and Collins, T and Freeman, A and Eldred-Evans, D and Bertoncelli-Tanaka, M and Tam, H and Ramachandran, N and Madaan, S and Winkler, M and Arya, M and Emberton, M and Ahmed, HU},
doi = {10.1016/S1470-2045(22)00016-X},
journal = {The Lancet Oncology},
pages = {428--438},
title = {Multiparametric ultrasound versus multiparametric MRI to diagnose prostate cancer (CADMUS): a prospective, multicentre, paired-cohort, confirmatory study},
url = {http://dx.doi.org/10.1016/S1470-2045(22)00016-X},
volume = {23},
year = {2022}
}

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TY  - JOUR
AB  - Background:Multiparametric MRI of the prostate followed by targeted biopsy is recommended for patients at risk of prostate cancer. However, multiparametric ultrasound is more readily available than multiparametric MRI. Data from paired-cohort validation studies and randomised, controlled trials support the use of multiparametric MRI, whereas the evidence for individual ultrasound methods and multiparametric ultrasound is only derived from case series. We aimed to establish the overall agreement between multiparametric ultrasound and multiparametric MRI to diagnose clinically significant prostate cancer.Methods:We conducted a prospective, multicentre, paired-cohort, confirmatory study in seven hospitals in the UK. Patients at risk of prostate cancer, aged 18 years or older, with an elevated prostate-specific antigen concentration or abnormal findings on digital rectal examination underwent both multiparametric ultrasound and multiparametric MRI. Multiparametric ultrasound consisted of B-mode, colour Doppler, real-time elastography, and contrast-enhanced ultrasound. Multiparametric MRI included high-resolution T2-weighted images, diffusion-weighted imaging (dedicated high B 1400 s/mm2 or 2000 s/mm2 and apparent diffusion coefficient map), and dynamic contrast-enhanced axial T1-weighted images. Patients with positive findings on multiparametric ultrasound or multiparametric MRI underwent targeted biopsies but were masked to their test results. If both tests yielded positive findings, the order of targeting at biopsy was randomly assigned (1:1) using stratified (according to centre only) block randomisation with randomly varying block sizes. The co-primary endpoints were the proportion of positive lesions on, and agreement between, multiparametric MRI and multiparametric ultrasound in identifying suspicious lesions (Likert score of ≥3), and detection of clinically significant cancer (defined as a Gleason score of ≥4+3 in any area or a maximum cancer core length
AU  - Grey,ADR
AU  - Scott,R
AU  - Shah,B
AU  - Acher,P
AU  - Liyanage,S
AU  - Pavlou,M
AU  - Omar,R
AU  - Chinegwundoh,F
AU  - Patki,P
AU  - Shah,TT
AU  - Hamid,S
AU  - Ghei,M
AU  - Gilbert,K
AU  - Campbell,D
AU  - Brew-Graves,C
AU  - Arumainayagam,N
AU  - Chapman,A
AU  - McLeavy,L
AU  - Karatziou,A
AU  - Alsaadi,Z
AU  - Collins,T
AU  - Freeman,A
AU  - Eldred-Evans,D
AU  - Bertoncelli-Tanaka,M
AU  - Tam,H
AU  - Ramachandran,N
AU  - Madaan,S
AU  - Winkler,M
AU  - Arya,M
AU  - Emberton,M
AU  - Ahmed,HU
DO  - 10.1016/S1470-2045(22)00016-X
EP  - 438
PY  - 2022///
SN  - 1213-9432
SP  - 428
TI  - Multiparametric ultrasound versus multiparametric MRI to diagnose prostate cancer (CADMUS): a prospective, multicentre, paired-cohort, confirmatory study
T2  - The Lancet Oncology
UR  - http://dx.doi.org/10.1016/S1470-2045(22)00016-X
UR  - http://hdl.handle.net/10044/1/94492
VL  - 23
ER  -

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