Imperial College London
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Professor Hashim Ahmed

Faculty of Medicine, Department of Surgery & Cancer

Chair in Urology (Clinical)
 
 
 
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Contact

 

hashim.ahmed

 
 
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Location

 

5L28Lab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brembilla:2022:10.3390/diagnostics12020231,
author = {Brembilla, G and Giganti, F and Sidhu, H and Imbriaco, M and Mallett, S and Stabile, A and Freeman, A and Ahmed, HU and Moore, C and Emberton, M and Punwani, S},
doi = {10.3390/diagnostics12020231},
journal = {Diagnostics},
pages = {1--10},
title = {Diagnostic accuracy of abbreviated Bi-parametric MRI (a-bpMRI) for prostate cancer detection and screening: a multi-reader study},
url = {http://dx.doi.org/10.3390/diagnostics12020231},
volume = {12},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - (1) Background: There is currently limited evidence on the diagnostic accuracy of abbreviated biparametric MRI (a-bpMRI) protocols for prostate cancer (PCa) detection and screening. In the present study, we aim to investigate the performance of a-bpMRI among multiple readers and its potential application to an imaging-based screening setting. (2) Methods: A total of 151 men who underwent 3T multiparametric MRI (mpMRI) of the prostate and transperineal template prostate mapping biopsies were retrospectively selected. Corresponding bpMRI (multiplanar T2WI, DWI, ADC maps) and a-bpMRI (axial T2WI and b 2000 s/mm2 DWI only) dataset were derived from mpMRI. Three experienced radiologists scored a-bpMRI, standard biparametric MRI (bpMRI) and mpMRI in separate sessions. Diagnostic accuracy and interreader agreement of a-bpMRI was tested for different positivity thresholds and compared to bpMRI and mpMRI. Predictive values of a-bpMRI were computed for lower levels of PCa prevalence to simulate a screening setting. The primary definition of clinically significant PCa (csPCa) was Gleason ≥ 4 + 3, or cancer core length ≥ 6 mm. (3) Results: The median age was 62 years, the median PSA was 6.8 ng/mL, and the csPCa prevalence was 40%. Using a cut off of MRI score ≥ 3, the sensitivity and specificity of a-bpMRI were 92% and 48%, respectively. There was no significant difference in sensitivity compared to bpMRI and mpMRI. Interreader agreement of a-bpMRI was moderate (AC1 0.58). For a low prevalence of csPCa (e.g., <10%), higher cut offs (MRI score ≥ 4) yield a more favourable balance between the predictive values and positivity rate of MRI. (4) Conclusion: Abbreviated bpMRI protocols could match the diagnostic accuracy of bpMRI and mpMRI for the detection of csPCa. If a-bpMRI is used in low-prevalence settings, higher cut-offs for MRI positivity should be prioritised.
AU  - Brembilla,G
AU  - Giganti,F
AU  - Sidhu,H
AU  - Imbriaco,M
AU  - Mallett,S
AU  - Stabile,A
AU  - Freeman,A
AU  - Ahmed,HU
AU  - Moore,C
AU  - Emberton,M
AU  - Punwani,S
DO  - 10.3390/diagnostics12020231
EP  - 10
PY  - 2022///
SN  - 2075-4418
SP  - 1
TI  - Diagnostic accuracy of abbreviated Bi-parametric MRI (a-bpMRI) for prostate cancer detection and screening: a multi-reader study
T2  - Diagnostics
UR  - http://dx.doi.org/10.3390/diagnostics12020231
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000767609700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.mdpi.com/2075-4418/12/2/231
UR  - http://hdl.handle.net/10044/1/98235
VL  - 12
ER  -
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