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@article{Ward:2017:10.1158/1055-9965.EPI-16-0886,
author = {Ward, HA and Wark, PA and Muller, DC and Steffen, A and Johansson, M and Norat, T and Gunter, MJ and Overvad, K and Dahm, CC and Halkjaer, J and Tjønneland, A and Boutron-Ruault, MC and Fagherazzi, G and Mesrine, S and Brennan, P and Freisling, H and Li, K and Kaaks, R and Trichopoulou, A and Lagiou, P and Panico, S and Grioni, S and Tumino, R and Vineis, P and Palli, D and Peeters, PHM and Bueno-de-Mesquita, HB and Weiderpass, E and Agudo, A and Ramon, Quiros J and Larrañaga, N and Ardanaz, E and Huerta, JM and Sánchez, MJ and Laurell, G and Johansson, I and Westin, U and Wallstrom, P and Bradbury, KE and Wareham, NJ and Khaw, KT and Pearson, C and Boeing, H and Riboli, E},
doi = {10.1158/1055-9965.EPI-16-0886},
journal = {Cancer Epidemiology Biomarkers & Prevention},
pages = {895--904},
title = {Measured adiposity in relation to head and neck cancer risk in the European Prospective Investigation into Cancer and Nutrition},
url = {http://dx.doi.org/10.1158/1055-9965.EPI-16-0886},
volume = {26},
year = {2017}
}

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TY  - JOUR
AB  - Background: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer (HNC). However, most studies have used self-reported anthropometry which is prone to error. Methods: Among 363 094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of HNC. HNC risk was examined in relation to body mass index (BMI) [lean: < 22.5 kg/m2, normal weight (reference): 22.5-24.9 kg/m2, overweight 25-29.9 kg/m2, obese: > 30 kg/m2], waist circumference (WC), hip circumference (HC) and waist to hip ratio (WHR) using Cox proportional hazards models. Results: Among men, a BMI < 22.5 kg/m2 was associated with higher HNC risk [hazard ratio (HR) 1.62, 95% confidence interval (CI) 1.23 - 2.12)]; BMI was not associated with HNC among women. WC and WHR were associated with greater risk of HNC among women, (WC per 5 cm: HR 1.08, 95% CI 1.02 - 1.15; WHR per 0.1 unit: HR 1.64, 95% CI 1.38 - 1.93). After stratification by smoking status, the association for WHR was present only among smokers (p interaction 0.004). Among men, WC and WHR were associated with HNC only upon additional adjustment for BMI (WC per 5 cm: HR 1.16, 95% CI 1.07 - 1.26; WHR per 0.1 unit: HR 1.42, 95% CI 1.21 - 1.65). Conclusion: Central adiposity, particularly among women, may have a stronger association with HNC risk than previously estimated. Impact: Strategies to reduce obesity may beneficially impact HNC incidence.
AU  - Ward,HA
AU  - Wark,PA
AU  - Muller,DC
AU  - Steffen,A
AU  - Johansson,M
AU  - Norat,T
AU  - Gunter,MJ
AU  - Overvad,K
AU  - Dahm,CC
AU  - Halkjaer,J
AU  - Tjønneland,A
AU  - Boutron-Ruault,MC
AU  - Fagherazzi,G
AU  - Mesrine,S
AU  - Brennan,P
AU  - Freisling,H
AU  - Li,K
AU  - Kaaks,R
AU  - Trichopoulou,A
AU  - Lagiou,P
AU  - Panico,S
AU  - Grioni,S
AU  - Tumino,R
AU  - Vineis,P
AU  - Palli,D
AU  - Peeters,PHM
AU  - Bueno-de-Mesquita,HB
AU  - Weiderpass,E
AU  - Agudo,A
AU  - Ramon,Quiros J
AU  - Larrañaga,N
AU  - Ardanaz,E
AU  - Huerta,JM
AU  - Sánchez,MJ
AU  - Laurell,G
AU  - Johansson,I
AU  - Westin,U
AU  - Wallstrom,P
AU  - Bradbury,KE
AU  - Wareham,NJ
AU  - Khaw,KT
AU  - Pearson,C
AU  - Boeing,H
AU  - Riboli,E
DO  - 10.1158/1055-9965.EPI-16-0886
EP  - 904
PY  - 2017///
SN  - 1538-7755
SP  - 895
TI  - Measured adiposity in relation to head and neck cancer risk in the European Prospective Investigation into Cancer and Nutrition
T2  - Cancer Epidemiology Biomarkers & Prevention
UR  - http://dx.doi.org/10.1158/1055-9965.EPI-16-0886
UR  - http://hdl.handle.net/10044/1/44671
VL  - 26
ER  -

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