Publications
44 results found
Rodriguez-Cuenca S, Cocheme HM, Logan A, et al., 2010, Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice, FREE RADICAL BIOLOGY AND MEDICINE, Vol: 48, Pages: 161-172, ISSN: 0891-5849
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- Citations: 172
Kelso GF, Maroz A, Ware DC, et al., 2009, The mechanism and mitochondrial activity of manganese(II) pentaazamacrocycle superoxide dismutase mimetics, Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
Graham D, Huynh NN, Hamilton CA, et al., 2009, Mitochondria-Targeted Antioxidant MitoQ<sub>10</sub> Improves Endothelial Function and Attenuates Cardiac Hypertrophy, HYPERTENSION, Vol: 54, Pages: 322-U233, ISSN: 0194-911X
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- Citations: 281
Cocheme HM, Murphy MR, 2009, THE UPTAKE AND INTERACTIONS OF THE REDOX CYCLER PARAQUAT WITH MITOCHONDRIA, METHODS IN ENZYMOLOGY, VOL 456, Vol: 456, Pages: 395-417, ISSN: 0076-6879
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- Citations: 29
Cocheme HM, Murphy MP, 2008, Complex I is the major site of mitochondrial superoxide production by paraquat, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 283, Pages: 1786-1798, ISSN: 0021-9258
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- Citations: 417
Smith RAJ, Adlam VJ, Blaikie FH, et al., 2008, Mitochondria-Targeted Antioxidants in the Treatment of Disease, MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS, Vol: 1147, Pages: 105-111, ISSN: 0077-8923
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- Citations: 95
Cocheme HM, Kelso GF, James AM, et al., 2007, Mitochondrial targeting of quinones: Therapeutic implications, MITOCHONDRION, Vol: 7, Pages: S94-S102, ISSN: 1567-7249
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- Citations: 105
Ross MF, Kelso GF, Blaikie FH, et al., 2005, Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology, Biokhimiya, Vol: 70, Pages: 273-283, ISSN: 0320-9725
Lipophilic phosphonium cations were first used to investigate mitochondrial biology by Vladimir Skulachev and colleagues in the late 1960s. Since then, these molecules have become important tools for exploring mitochondrial bioenergetics and free radical biology. Here we review why these molecules are useful in mitochondrial research and outline some of the ways in which they are now being utilized.
James AM, Cochemé HM, Murphy MP, 2005, Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing, MECHANISMS OF AGEING AND DEVELOPMENT, Vol: 126, Pages: 982-986, ISSN: 0047-6374
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- Citations: 63
James AM, Cochemé HM, Smith RAJ, et al., 2005, Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species -: Implications for the use of exogenous ubiquinones as therapies and experimental tools, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 280, Pages: 21295-21312
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- Citations: 302
Ross MF, Kelso GF, Blaikie FH, et al., 2005, Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology, BIOCHEMISTRY-MOSCOW, Vol: 70, Pages: 222-230, ISSN: 0006-2979
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- Citations: 397
Murphy MP, Echtay KS, Blaikie FH, et al., 2003, Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation -: Studies using a mitochondria-targeted spin trap derived from α-phenyl-<i>N-tert</i>-butylnitrone, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 278, Pages: 48534-48545, ISSN: 0021-9258
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- Citations: 274
Smith RAJ, Kelso GF, Blaikie FH, et al., 2003, Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 31, Pages: 1295-1299, ISSN: 0300-5127
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- Citations: 40
Smith RAJ, Kelso GF, Blaikie FH, et al., 2003, Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences, Pages: 1295-1299, ISSN: 0300-5127
The production of ROS (reactive oxygen species) by the mitochondrial respiratory chain contributes to a range of pathologies, including neurodegenerative diseases, ischaemia/reperfusion injury and aging. There are also indications that mitochondrial ROS production plays a role in damage response and signal transduction pathways. To unravel the role of mitochondrial ROS production in these processes, we have developed a range of mitochondria-targeted probe molecules. Covalent attachment of a lipophilic cation leads to their accumulation into mitochondria, driven by the membrane potential. Molecules developed so far include antioxidants designed to intercept mitochondrial ROS and reagents that specifically label mitochondrial thiol proteins. Here we outline how mitochondrial ROS formation and its consequences can be investigated using these probes.
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