Imperial College London
Alternate

DrHelenaCocheme

Faculty of Medicine, Institute of Clinical Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

helena.cocheme Website

 
 
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Location

 

4.15ELMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lennicke:2020:10.1042/bst20190052,
author = {Lennicke, C and Cochemé, HM},
doi = {10.1042/bst20190052},
journal = {Biochemical Society Transactions},
pages = {367--377},
title = {Redox signalling and ageing: insights from Drosophila},
url = {http://dx.doi.org/10.1042/bst20190052},
volume = {48},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Ageing and age-related diseases are major challenges for the social, economic and healthcare systems of our society. Amongst many theories, reactive oxygen species (ROS) have been implicated as a driver of the ageing process. As by-products of aerobic metabolism, ROS are able to randomly oxidise macromolecules, causing intracellular damage that accumulates over time and ultimately leads to dysfunction and cell death. However, the genetic overexpression of enzymes involved in the detoxification of ROS or treatment with antioxidants did not generally extend lifespan, prompting a re-evaluation of the causal role for ROS in ageing. More recently, ROS have emerged as key players in normal cellular signalling by oxidising redox-sensitive cysteine residues within proteins. Therefore, while high levels of ROS may be harmful and induce oxidative stress, low levels of ROS may actually be beneficial as mediators of redox signalling. In this context, enhancing ROS production in model organisms can extend lifespan, with biological effects dependent on the site, levels, and specific species of ROS. In this review, we examine the role of ROS in ageing, with a particular focus on the importance of the fruit fly Drosophila as a powerful model system to study redox processes in vivo.
AU  - Lennicke,C
AU  - Cochemé,HM
DO  - 10.1042/bst20190052
EP  - 377
PY  - 2020///
SN  - 0300-5127
SP  - 367
TI  - Redox signalling and ageing: insights from Drosophila
T2  - Biochemical Society Transactions
UR  - http://dx.doi.org/10.1042/bst20190052
UR  - https://portlandpress.com/biochemsoctrans/article/doi/10.1042/BST20190052/222435/Redox-signalling-and-ageing-insights-from
UR  - http://hdl.handle.net/10044/1/77589
VL  - 48
ER  -
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