Imperial College London
Alternate

DrHelenaCocheme

Faculty of Medicine, Institute of Clinical Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

helena.cocheme Website

 
 
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Location

 

4.15ELMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cabreiro:2013:10.1016/j.cell.2013.02.035,
author = {Cabreiro, F and Au, C and Leung, KY and Vergara-Irigaray, N and Cochemé, HM and Noori, T and Weinkove, D and Schuster, E and Greene, ND and Gems, D},
doi = {10.1016/j.cell.2013.02.035},
journal = {Cell},
pages = {228--239},
title = {Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism},
url = {http://dx.doi.org/10.1016/j.cell.2013.02.035},
volume = {153},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The biguanide drug metformin is widely prescribed to treat type 2 diabetes and metabolic syndrome, but its mode of action remains uncertain. Metformin also increases lifespan in Caenorhabditis elegans cocultured with Escherichia coli. This bacterium exerts complex nutritional and pathogenic effects on its nematode predator/host that impact health and aging. We report that metformin increases lifespan by altering microbial folate and methionine metabolism. Alterations in metformin-induced longevity by mutation of worm methionine synthase (metr-1) and S-adenosylmethionine synthase (sams-1) imply metformin-induced methionine restriction in the host, consistent with action of this drug as a dietary restriction mimetic. Metformin increases or decreases worm lifespan, depending on E. coli strain metformin sensitivity and glucose concentration. In mammals, the intestinal microbiome influences host metabolism, including development of metabolic disease. Thus, metformin-induced alteration of microbial metabolism could contribute to therapeutic efficacy-and also to its side effects, which include folate deficiency and gastrointestinal upset.
AU  - Cabreiro,F
AU  - Au,C
AU  - Leung,KY
AU  - Vergara-Irigaray,N
AU  - Cochemé,HM
AU  - Noori,T
AU  - Weinkove,D
AU  - Schuster,E
AU  - Greene,ND
AU  - Gems,D
DO  - 10.1016/j.cell.2013.02.035
EP  - 239
PY  - 2013///
SN  - 1097-4172
SP  - 228
TI  - Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism
T2  - Cell
UR  - http://dx.doi.org/10.1016/j.cell.2013.02.035
UR  - http://hdl.handle.net/10044/1/40463
VL  - 153
ER  -
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