Imperial College London
Alternate

DrHelenaCocheme

Faculty of Medicine, Institute of Clinical Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

helena.cocheme Website

 
 
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Location

 

4.15ELMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Augustin:2017:10.1242/dev.152975,
author = {Augustin, H and McGourty, K and Steinert, JR and Cocheme, HM and Adcott, J and Cabecinha, M and Vincent, A and Halff, EF and Kittler, JT and Boucrot, E and Partridge, L},
doi = {10.1242/dev.152975},
journal = {Development},
pages = {2445--2455},
title = {Myostatin-like proteins regulate synaptic function and neuronal morphology},
url = {http://dx.doi.org/10.1242/dev.152975},
volume = {144},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Growth factors of the TGFβ superfamily play key roles in regulating neuronal and muscle function. Myostatin (or GDF8) and GDF11 are potent negative regulators of skeletal muscle mass. However, expression of myostatin and its cognate receptors in other tissues, including brain and peripheral nerves, suggests a potential wider biological role. Here, we show that Myoglianin (MYO), the Drosophila homolog of myostatin and GDF11, regulates not only body weight and muscle size, but also inhibits neuromuscular synapse strength and composition in a Smad2-dependent manner. Both myostatin and GDF11 affected synapse formation in isolated rat cortical neuron cultures, suggesting an effect on synaptogenesis beyond neuromuscular junctions. We also show that MYO acts in vivo to inhibit synaptic transmission between neurons in the escape response neural circuit of adult flies. Thus, these anti-myogenic proteins act as important inhibitors of synapse function and neuronal growth.
AU  - Augustin,H
AU  - McGourty,K
AU  - Steinert,JR
AU  - Cocheme,HM
AU  - Adcott,J
AU  - Cabecinha,M
AU  - Vincent,A
AU  - Halff,EF
AU  - Kittler,JT
AU  - Boucrot,E
AU  - Partridge,L
DO  - 10.1242/dev.152975
EP  - 2455
PY  - 2017///
SN  - 0950-1991
SP  - 2445
TI  - Myostatin-like proteins regulate synaptic function and neuronal morphology
T2  - Development
UR  - http://dx.doi.org/10.1242/dev.152975
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000404631000013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/52487
VL  - 144
ER  -
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