Imperial College London

DrHolgerAuner

Faculty of MedicineDepartment of Immunology and Inflammation

Clinical Senior Lecturer
 
 
 
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Contact

 

holger.auner04 Website

 
 
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Assistant

 

Miss Mandy Sale +44 (0)20 3313 4017

 
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Location

 

4N7ACommonwealth BuildingHammersmith Campus

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Summary

 

Summary

Dr Holger Auner is a Clinical Senior Lecturer and Consultant at the Centre for Haematology. He received his MD from Karl-Franzens University Graz, Austria, where he also trained in Internal Medicine/Haematology/Medical Oncology and studied genetic instability in myeloid leukaemias in the laboratory of Professor Heinz Sill. He then joined the group of Professor Niall Dillon at the MRC Clinical Sciences Centre as a Kay Kendall Leukaemia Fund Junior Research Fellow and obtained his PhD for work on plasma cell biology from Imperial College London. Subsequently, he was the Stem Cell Transplant Co-ordinator in the Centre for Haematology at Hammersmith Hospital before returning to Professor Dillon’s lab for postdoctoral work on proteotoxic stress in myeloma cells. He was awarded a Cancer Research UK Clinician Scientist Fellowship in 2012 and is now leading a research group at Imperial’s Centre for Haematology. Dr Auner’s primary research interest is to better understand aspects of protein degradation pathways in multiple myeloma and other cancers, with the ultimate goal of finding novel therapeutic approaches. His lab, the 'Cancer Cell Protein Metabolism' group, also investigates the effects of proteostasis-targeting drugs on tissue properties. Dr Auner is an active member of the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation (EBMT) and the European Myeloma Network (EMN), principal investigator for Imperial College London/Imperial College Healthcare NHS Trust for national and international trials (MUKfive, MUKeight, MUKtwelve; BOSTON) and member of the UK Myeloma Research Alliance. He has published on various molecular and clinical aspects of haematological malignancies, in particular multiple myeloma. 

***NEWS***



08/2019 -- Dr Auner has been awarded a CRUK Advanced Clinician Scientist Fellowship that will fund a substantial myeloma research programme for the next 5 years.

07/2019 -- we have formally started work on our CRUK Small Molecule Drug Discovery Project award, which is supported by SU2C, and welcome Dr Elena Lopez-Jimenez (previously at the Spanish National Cardiovascular Centre (CNIC), Spanish National Cancer Centre (CNIO), and Imperial/Surgery and Cancer) to the team!

01/2019 --- Parzych K et al, 'The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation' is published in ONCOGENE

12/2018 --- we have been awarded a CRUK Small Molecule Drug Discovery Project grant which will start in early 2019 (and we'll be looking for a post-doc)

11/2018 --- Loaiza et al, 'An engineered, quantifiable in vitro model for analysing the effect of proteostasis-targeting drugs on tissue physical properties' is published in BIOMATERIALS and becomes a 'most downloaded article' on the journal webpage

Auner lab members (2018-2019)

Elena Lopez-Jimenz (post-doc)

Paula Saavedra Garcia (post-doc)

Sandra Loaiza (PhD student and Director of The John Goldman Centre for Cellular Therapy at ICHNT)

Hibah Al-Sadah (PhD student)

Xiaobei Xiong (MRes Cancer Biology, 2018/19)

Celine Collin (UROP/Masters in Pharmacology - Paris Descartes)

Tomohito Shimada (Tokyo Medical and Dental University)

Previous lab members (and subsequent destinations)

Lucy Penfold (maternity cover post-doc, 2018; --> post-doc @ MRC LIMS)

Katarzyna Parzych (post-doc, 2012-2018; --> Trials Coordinator @ UCLH)

Desislava Kuzeva (MRes Cancer Biology, 2016/17; --> PhD @ King's College London)

Dinusha Fernando (MRes Cancer Biology, 2017/18; --> Research Technician in Cancer Immunotherapy at UCL)

Angie Ruiz Tellez (MSc Molecular Medicine, 2017; --> Research Intern @ Imperial)

Noushin Masoudi (MSc in Genes, Drugs and Stem Cells, 2017; --> PhD @ Imperial)

Max Zi Chen (maternity cover post-doc, 2015; --> post-doc @ Imperial then in Cambridge)

Tamara Chinn (Whitaker Fellow; with Dr Eileen Gentleman, King's College London, 2014-2015; --> Medical School in the US)

Viktoria Holzmann (Erasmus/UROP BSc student, 2016; --> Masters in Vienna, Austria)

Research Collaborations

Professor Anastasios Karadimitris, Imperial College London

Professor Hector Keun, Imperial College London

Professor Matt Fuchter, Imperial College London

Professor Mauricio Barahona, Imperial College London

Dr Eileen Gentleman, King's College London

Dr Eric Chevet, French National Institute for Health and Medical Research (Inserm), Rennes

Dr Martin Kaiser, The Institut of Cancer Research, London/Sutton

Professor Kwee Yong (UCL)

Professor Monika Engelhardt, Freiburg, Germany


 

Selected Publications

Journal Articles

Parzych K, Saavedra Garcia P, Valbuena G, et al., 2019, The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation, Oncogene, ISSN:0950-9232

Loaiza S, Ferreira SA, Chinn TM, et al., 2018, An engineered, quantifiable in vitro model for analysing the effect of proteostasis-targeting drugs on tissue physical properties., Biomaterials, Vol:183, Pages:102-113

Kaliszczak M, Hechanova E, Alsadah H, et al., 2018, The HDAC6 inhibitor C1A modulates autophagy substrates in diverse cancer cells and induces cell death, British Journal of Cancer, Vol:119, ISSN:0007-0920, Pages:1278-1287

Ferreira SA, Motwani MS, Faull PA, et al., 2018, Bi-directional cell-pericellular matrix interactions direct stem cell fate, Nature Communications, Vol:9, ISSN:2041-1723

Ferreira SA, Faull PA, Seymore AJ, et al., 2018, Neighboring cells override 3D hydrogel matrix cues to drive human MSC quiescence, Biomaterials, Vol:176, ISSN:0142-9612, Pages:13-23

Auner HW, Yong KL, 2018, More convenient proteasome inhibition for improved outcomes, Lancet Oncology, Vol:19, ISSN:1470-2045, Pages:856-858

Larocca A, Dold SM, Zweegman S, et al., 2018, Patient-centered practice in elderly myeloma patients: an overview and consensus from the European Myeloma Network (EMN), Leukemia, Vol:32, ISSN:1476-5551, Pages:1697-1712

Gay F, Engelhardt M, Terpos E, et al., 2017, From transplant to novel cellular therapies in multiple myeloma: EMN guidelines and future perspectives., Haematologica - the Hematology Journal, Vol:103, ISSN:0390-6078, Pages:197-211

Auner H, Parzych K, Chinn TM, et al., 2015, Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97, Cell Death & Disease, Vol:6, ISSN:2041-4889

Auner HW, Beham-Schmid C, Dillon N, et al., 2010, The life span of short-lived plasma cells is partly determined by a block on activation of apoptotic caspases acting in combination with endoplasmic reticulum stress, Blood, Vol:116, ISSN:0006-4971, Pages:3445-3455

Sabbattini P, Canzonetta C, Sjoberg M, et al., 2007, Novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells, EMBO Journal, Vol:26, ISSN:0261-4189, Pages:4657-4669

Conference

Parzych K, Loaiza S, Chinn TM, et al., 2015, Comprehensive failure of intracellular protein homeostasis kills myeloma and solid cancer cells following VCP/p97 inhibition, 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), AMER ASSOC CANCER RESEARCH, ISSN:0008-5472

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