Publications
151 results found
Palani R, Lasa M, Giles C, et al., 2014, HIGH DOSE ETOPOSIDE/GCSF IS A SAFE AND EFFECTIVE MOBILIZATION REGIMEN IN MULTIPLE MYELOMA: A SINGLE-INSTITUTION EXPERIENCE, 40th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S534-S534, ISSN: 0268-3369
Auner HW, Szydlo R, Hoek J, et al., 2014, AGE-RELATED TRENDS IN UTILISATION AND OUTCOME OF AUTOLOGOUS HAEMATOPOIETIC CELL TRANSPLANTATION FOR MULTIPLE MYELOMA - A STUDY BY THE PLASMA CELL SUBCOMMITTEE OF THE EBMT CHRONIC MALIGNANCIES WORKING PARTY, 40th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S92-S93, ISSN: 0268-3369
Auner HW, Szydlo R, van Biezen A, et al., 2013, Reduced intensity-conditioned allogeneic stem cell transplantation for multiple myeloma relapsing or progressing after autologous transplantation: a study by the European Group for Blood and Marrow Transplantation, BONE MARROW TRANSPLANTATION, Vol: 48, Pages: 1395-1400, ISSN: 0268-3369
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- Citations: 34
Auner HW, Szydlo R, Rone A, et al., 2013, Salvage autologous stem cell transplantation for multiple myeloma relapsing or progressing after up-front autologous transplantation, LEUKEMIA & LYMPHOMA, Vol: 54, Pages: 2200-2204, ISSN: 1042-8194
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- Citations: 37
Auner HW, Moody AM, Ward TH, et al., 2013, Combined Inhibition of p97 and the Proteasome Causes Lethal Disruption of the Secretory Apparatus in Multiple Myeloma Cells, PLOS One, Vol: 8, ISSN: 1932-6203
Inhibition of the proteasome is a widely used strategy for treating multiple myeloma that takes advantage of the heavy secretory load that multiple myeloma cells (MMCs) have to deal with. Resistance of MMCs to proteasome inhibition has been linked to incomplete disruption of proteasomal endoplasmic-reticulum (ER)-associated degradation (ERAD) and activation of non-proteasomal protein degradation pathways. The ATPase p97 (VCP/Cdc48) has key roles in mediating both ERAD and non-proteasomal protein degradation and can be targeted pharmacologically by small molecule inhibition. In this study, we compared the effects of p97 inhibition with Eeyarestatin 1 and DBeQ on the secretory apparatus of MMCs with the effects induced by the proteasome inhibitor bortezomib, and the effects caused by combined inhibition of p97 and the proteasome. We found that p97 inhibition elicits cellular responses that are different from those induced by proteasome inhibition, and that the responses differ considerably between MMC lines. Moreover, we found that dual inhibition of both p97 and the proteasome terminally disrupts ER configuration and intracellular protein metabolism in MMCs. Dual inhibition of p97 and the proteasome induced high levels of apoptosis in all of the MMC lines that we analysed, including bortezomib-adapted AMO-1 cells, and was also effective in killing primary MMCs. Only minor toxicity was observed in untransformed and non-secretory cells. Our observations highlight non-redundant roles of p97 and the proteasome in maintaining secretory homeostasis in MMCs and provide a preclinical conceptual framework for dual targeting of p97 and the proteasome as a potential new therapeutic strategy in multiple myeloma.
Auner HW, Szydlo R, van Biezen A, et al., 2013, Reduced-intensity conditioned allogeneic stem cell transplantation for multiple myeloma relapsing or progressing after autologous transplantation : a study by the European Group for Blood and Marrow Transplantation Chronic Malignancies Working Party, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S17-S17, ISSN: 0268-3369
Auner HW, Szydlo R, Rone A, et al., 2013, Salvage autologous stem cell transplantation for multiple myeloma relapsing or progressing after up-front autologous transplantation, BONE MARROW TRANSPLANTATION, Vol: 48, Pages: S199-S199, ISSN: 0268-3369
Krause R, Valentin T, Salzer H, et al., 2012, Which lumen is the source of catheter-related bloodstream infection in patients with multi-lumen central venous catheters?, Infection, Vol: 41, Pages: 49-52
Garnett C, Giles C, Ahmed O, et al., 2012, Tandem Autologous Stem Cell Transplantation in Chemorefractory Multiple Myeloma, 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971
Garnett C, Giles C, Lasa M, et al., 2012, Third Autologous Stem Cell Transplantation for Relapsed Multiple Myeloma, 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971
Weissinger F, Auner HW, Bertz H, et al., 2012, Antimicrobial therapy of febrile complications after high-dose chemotherapy and autologous hematopoietic stem cell transplantation-guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO), ANNALS OF HEMATOLOGY, Vol: 91, Pages: 1161-1174, ISSN: 0939-5555
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- Citations: 23
Pavlu J, Rezvani K, Kishore B, et al., 2012, Optimising patient selection for allogeneic stem cell transplantation: prediction of non-relapse mortality and survival, 38th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S27-S28, ISSN: 0268-3369
Auner HW, Pavlu J, Szydlo R, et al., 2012, Autologous haematopoietic stem cell transplantation in multiple myeloma patients from ethnic minority groups in an equal access healthcare system, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 157, Pages: 125-127, ISSN: 0007-1048
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- Citations: 9
Pavlu J, Auner HW, Ellis S, et al., 2011, LACE-conditioned autologous stem cell transplantation for relapsed or refractory diffuse large B-cell lymphoma: treatment outcome and risk factor analysis from a single centre, HEMATOLOGICAL ONCOLOGY, Vol: 29, Pages: 75-80, ISSN: 0278-0232
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- Citations: 8
Auner HW, Mazzarella L, Cook L, et al., 2011, High rate of stem cell mobilization failure after thalidomide and oral cyclophosphamide induction therapy for multiple myeloma, BONE MARROW TRANSPLANTATION, Vol: 46, Pages: 364-367, ISSN: 0268-3369
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- Citations: 11
Pavlu J, Shah R, Auner HW, et al., 2010, Preconditioning Level of C Reactive Protein and Disease Stage Are Key Prognostic Factors In Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation, Pages: 1433-1434, ISSN: 0006-4971
Pavlu J, Shah R, Auner HW, et al., 2010, Preconditioning Level of C-Reactive Protein and Disease Stage Are Key Prognostic Factors In Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation, 52nd Annual Meeting of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, Pages: 1433-1434, ISSN: 0006-4971
Auner HW, Beham-Schmid C, Dillon N, et al., 2010, The life span of short-lived plasma cells is partly determined by a block on activation of apoptotic caspases acting in combination with endoplasmic reticulum stress, BLOOD, Vol: 116, Pages: 3445-3455, ISSN: 0006-4971
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- Citations: 42
Krause R, Salzer HF, Hoenigl M, et al., 2010, Comparison of fluorescence <i>in situ</i> hybridisation using peptide nucleic acid probes, Gram stain/acridine orange leukocyte cytospin and differential time to positivity methods for detection of catheter-related bloodstream infection in patients after haematopoietic stem cell transplantation, CLINICAL MICROBIOLOGY AND INFECTION, Vol: 16, Pages: 1591-1593, ISSN: 1198-743X
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- Citations: 5
Pavlu J, Kew AK, Taylor-Roberts B, et al., 2010, Optimizing patient selection for myeloablative allogeneic hematopoietic cell transplantation in chronic myeloid leukemia in chronic phase, BLOOD, Vol: 115, Pages: 4018-4020, ISSN: 0006-4971
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- Citations: 46
Dannie E, Auner H, Davis J, et al., 2010, Single-centre experience on PBSC mobilization using plerixafor, 36th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantat/9th Meeting of the EBMT Data-Management-Group/26th Meeting of the EBMT Nurses Group/2nd EBMT Qual Management Meeting, Publisher: NATURE PUBLISHING GROUP, Pages: S352-S352, ISSN: 0268-3369
Pavlu J, Kew A, Taylor-Roberts B, et al., 2010, Optimizing patient selection for myeloablative allogeneic haemopoietic cell transplantation in chronic myeloid leukaemia in chronic phase, 36th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantat/9th Meeting of the EBMT Data-Management-Group/26th Meeting of the EBMT Nurses Group/2nd EBMT Qual Management Meeting, Publisher: NATURE PUBLISHING GROUP, Pages: S239-S239, ISSN: 0268-3369
Pavlu J, Auner H, Ellis S, et al., 2010, LACE-conditioned autologous stem cell transplantation for relapsed or refractory diffuse large B-cell lymphoma: treatment outcome and risk factor analysis from a single centre, BONE MARROW TRANSPLANTATION, Vol: 45, Pages: S255-S255, ISSN: 0268-3369
Auner H, Mazzarella L, Cook L, et al., 2010, High rate of stem cell mobilization failure after thalidomide and cyclophosphamide induction therapy for myeloma, BONE MARROW TRANSPLANTATION, Vol: 45, Pages: S21-S21, ISSN: 0268-3369
Auner HW, Mazzarella L, Cook L, et al., 2009, The Combination of Cyclophosphamide and Thalidomide During Induction Therapy for Multiple Myeloma Results in a High Rate of Stem Cell Mobilization Failure, 51st Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 844-844, ISSN: 0006-4971
Chaidos A, Giles C, Auner HW, et al., 2009, Second Autologous Stem Cell Transplantation Is Effective Salvage Therapy for Relapsed Multiple Myeloma, 51st Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 507-507, ISSN: 0006-4971
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- Citations: 1
Auner HW, Owiti H, Giles C, et al., 2009, Ethnic Disparity in Access to Stem Cell Transplantation for Multiple Myeloma., 51st Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 708-709, ISSN: 0006-4971
Pavlu J, Kew A, Taylor-Roberts B, et al., 2009, Optimizing Patient Selection for Allogeneic Stem Cell Transplantation in Chronic Myeloid Leukemia, 51st Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 1317-1317, ISSN: 0006-4971
Farah N, Auner H, Kanfer E, et al., 2009, Uptake and outcome of artificial reproductive techniques following SCT for leukaemia: a single-centre experience, 35th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S164-S164, ISSN: 0268-3369
Pavlu J, Auner H, Szydlo R, et al., 2009, Allogeneic myeloablative haematopoietic stem cell transplantation for chronic myeloid leukaemia in the imatinib era, 35th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S49-S49, ISSN: 0268-3369
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