Professor Sir Huw Thomas

Faculty of Medicine, Department of Surgery & Cancer

Professor

Contact

+44 (0)20 8235 4266huw.thomas

Location

St Marks HospitalNorthwick Park and St Marks Site

Summary

Professor Thomas studied at Trinity College Cambridge and the London Hospital Medical College graduating in 1982. He trained at The London, Royal Free, St Mark's and St Mary's Hospitals. He was a Clinical Research Fellow at the Imperial Cancer Research Fund and wrote his PhD thesis on 'Molecular analysis of the Adenomatous Polyposis Coli gene region'. In 1994 he was appointed consultant physician and gastroenterologist at St Mary's and senior lecturer in the Imperial Cancer Research Fund Colorectal Cancer Unit at St Mark's. In 2007 he was appointed chair of gastrointestinal genetics at Imperial.

He heads the family cancer group at St Mark's. The aims of the group are to define the inherited predispositions to colorectal cancer and refine the management of familial risk.

His principal research interests are in the fields of:

Assessment of familial risk of colorectal cancer

Modification of familial risk by genetic testing

Colonoscopic surveillance for familial risk of colorectal cancer

Molecular genetic studies in familial colorectal cancer

Chemoprevention studies in familial colorectal cancer

He has long-standing collaborative research projects with Professor Peter Sasieni (Academic Director of Kings Clinical Trials Unit, King College London), Professor Ian Tomlinson FRS (Director of Edinburgh Cancer Research Centre) and Professor Sir John Burn (University of Newcastle).

He has been Head of HM Medical Household and Physician to the Queen since 2014. He was appointed KCVO in the 2021 New Year Honours.

Publications

Journals

Moller P, Seppala T, Dowty JG, et al.Moller P, Seppala T, Dowty JG, Haupt S, Dominguez-Valentin M, Sunde L, Bernstein I, Engel C, Aretz S, Nielsen M, Capella G, Evans DG, Burn J, Holinski-Feder E, Bertario L, Bonanni B, Lindblom A, Levi Z, Macrae F, Winship I, Plazzer J-P, Sijmons R, Laghi L, Della Valle A, Heinimann K, Half E, Lopez-Koestner F, Alvarez-Valenzuela K, Scott RJ, Katz L, Laish I, Vainer E, Vaccaro CA, Carraro DM, Gluck N, Abu-Freha N, Stakelum A, Kennelly R, Winter D, Rossi BM, Greenblatt M, Bohorquez M, Sheth H, Tibiletti MG, Lino-Silva LS, Horisberger K, Portenkirchner C, Nascimento I, Rossi NT, da Silva LA, Thomas H, Zarand A, Mecklin J-P, Pylvanainen K, Renkonen-Sinisalo L, Lepisto A, Peltomaki P, Therkildsen C, Lindberg LJ, Thorlacius-Ussing O, von Knebel Doeberitz M, Loeffler M, Rahner N, Steinke-Lange V, Schmiegel W, Vangala D, Perne C, Hueneburg R, de Vargas AF, Latchford A, Gerdes A-M, Backman A-S, Guillen-Ponce C, Snyder C, Lautrup CK, Amor D, Palmero E, Stoffel E, Duijkers F, Hall MJ, Hampel H, Williams H, Okkels H, Lubinski J, Reece J, Ngeow J, Guillem JG, Arnold J, Wadt K, Monahan K, Senter L, Rasmussen LJ, van Hest LP, Ricciardiello L, Kohonen-Corish MRJ, Ligtenberg MJL, Southey M, Aronson M, Zahary MN, Samadder NJ, Poplawski N, Hoogerbrugge N, Morrison PJ, James P, Lee G, Chen-Shtoyerman R, Ankathil R, Pai R, Ward R, Parry S, Debniak T, John T, van Overeem Hansen T, Caldes T, Yamaguchi T, Barca-Tierno V, Garre P, Cavestro GM, Weitz J, Redler S, Buettner R, Heuveline V, Hopper JL, Win AK, Lindor N, Gallinger S, Le Marchand L, Newcomb PA, Figueiredo J, Buchanan DD, Thibodeau SN, ten Broeke SW, Hovig E, Nakken S, Pineda M, Duenas N, Brunet J, Green K, Lalloo F, Newton K, Crosbie EJ, Mints M, Tjandra D, Neffa F, Esperon P, Kariv R, Rosner G, Pavicic WH, Kalfayan P, Torrezan GT, Bassaneze T, Martin C, Moslein G, Ahadova A, Kloor M, Sampson JR, Jenkins MA close, 2022, Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium, Hereditary Cancer in Clinical Practice, Vol:20, ISSN:1731-2302, Pages:1-11

Monahan KJ, Lincoln A, East JE, et al.Monahan KJ, Lincoln A, East JE, Benton S, Burn J, DeSouza B, Hanson H, Lalloo F, McVeigh T, Rutter MD, Snape K, Thomas HJW, Sasieni P close, 2020, Management strategies for the colonoscopic surveillance of people with Lynch syndrome during the COVID-19 pandemic, Gut, ISSN:0017-5749

Burn J, Sheth H, Elliott F, et al.Burn J, Sheth H, Elliott F, Reed L, Macrae F, Mecklin J-P, Möslein G, McRonald FE, Bertario L, Evans DG, Gerdes A-M, Ho JWC, Lindblom A, Morrison PJ, Rashbass J, Ramesar R, Seppälä T, Thomas HJW, Pylvänäinen K, Borthwick GM, Mathers JC, Bishop DT, CAPP2 Investigators close, 2020, Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial, The Lancet, Vol:395, ISSN:0140-6736, Pages:1855-1863

Monahan KJ, Bradshaw N, Dolwani S, et al.Monahan KJ, Bradshaw N, Dolwani S, Desouza B, Dunlop MG, East JE, Ilyas M, Kaur A, Lalloo F, Latchford A, Rutter MD, Tomlinson I, Thomas HJW, Hill J, Hereditary CRC guidelines eDelphi consensus group close, 2020, Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG), Gut, Vol:69, ISSN:0017-5749, Pages:411-444

Burn J, Alsina D, Hill J, et al.Burn J, Alsina D, Hill J, Rees C, Tischkowitz M, Monahan K, Thomas H, Rutter M, Fearnhead N, Evans G, Lalloo F, Atkin W close, 2017, Response: A clinical consensus on improving the colonoscopic screening and surveillance of people with Lynch syndrome in England, British Medical Journal, Vol:356, ISSN:0959-8138

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