Publications
137 results found
Dove-Edwin I, Williams CB, Sasieni P, et al., 2001, Familial colorectal cancer; Outcome of colonoscopic surveillance in dominant families with and without hereditary nonpolyposis colorectal cancer microsatellite instability, GUT, Vol: 48, Pages: A22-A22, ISSN: 0017-5749
Lipton L, Thomas HJ, Eeles RA, et al., 2001, Apparent Mendelian inheritance of breast and colorectal cancer: chance, genetic heterogeneity or a new gene?, Fam Cancer, Vol: 1, Pages: 189-195, ISSN: 1389-9600
It is not uncommon for cancer geneticists to be referred families with apparently Mendelian co-inheritance of breast and bowel cancer. Such families present a particular problem as regards the intensity of their screening for these diseases and the utility of genetic testing. Many 'breast-colon' cancer families probably result from chance clustering of two common cancers. Other 'breast-colon' cancer families may result from known cancer syndromes, such as hereditary breast-ovarian cancer or hereditary non-polyposis colon cancer, either by conferring a high risk of one cancer type and a slightly increased risk of the other, or through a predisposition to one of the two cancers and chance occurrence of the other. Anecdotally, however, many geneticists wonder about the existence of a distinct 'breast-colon cancer syndrome', since some families present good a priori evidence of genetic disease and yet cannot readily be accounted for by known genes or chance. The identification of unknown 'breast-colon cancer' genes is likely to be difficult, relying primarily on candidate gene analysis, including loci separately implicated in breast or colorectal cancer, or in other multiple cancer syndromes. Studies such as those on APC I1307K and CHEK2 1100delC may suggest the way forward for the identification of 'breast-colon cancer' genes.
Dove-Edwin I, Goff S, Bradburn D, et al., 2000, Incidence of interval cancer on follow-up colonoscopy in individuals with a family history of colorectal cancer undergoing colonoscopic surveillance., GASTROENTEROLOGY, Vol: 118, Pages: A41-A41, ISSN: 0016-5085
Brooker JC, Shah SG, Thapar CJ, et al., 2000, Pan-colonic dyespray to aid adenoma detection during colonoscopy: A randomised controlled trial., GASTROINTESTINAL ENDOSCOPY, Vol: 51, Pages: AB102-AB102, ISSN: 0016-5107
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- Citations: 1
Dove-Edwin I, Williams CB, Thomas HJ, 2000, Prevalence of colorectal adenomas in individuals with a family history of colorectal cancer based on initial colonoscopy: Implications for colonoscopic surveillance., GASTROENTEROLOGY, Vol: 118, Pages: A1385-A1385, ISSN: 0016-5085
Lockett MJ, Atkin WS, Thomas HJW, et al., 2000, Hyperplastic (metaplastic) colorectal polyps: Neoplastic lesions?, CME Journal Gastroenterology, Hepatology and Nutrition, Vol: 3, Pages: 39-43, ISSN: 1367-9015
Hyperplastic polyps are one of the commonest colorectal polyps and have traditionally been thought to be non-neoplastic lesions, with no malignant potential. Evidence is accumulating to suggest that the hyperplastic polyp has more significance than is generally recognised. In this review we show how the colorectal hyperplastic polyp possesses epidemiological, histochemical and genetic properties of neoplasia, while showing differences from normal mucosa. We describe the related serrated adenoma and the condition hyperplastic polyposis and discuss the implications for colorectal cancer genetics and to the practicing clinician.
Swale VJ, Quinn AG, Wheeler JM, et al., 1999, Microsatellite instability in benign skin lesions in hereditary non-polyposis colorectal cancer syndrome, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 113, Pages: 901-905, ISSN: 0022-202X
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- Citations: 21
Swale VJ, Quinn AG, Wheeler JM, et al., 1999, Microsatellite instability in benign skin lesions in hereditary nonpolyposis colorectal cancer syndrome., BRITISH JOURNAL OF CANCER, Vol: 80, Pages: 26-26, ISSN: 0007-0920
Tomlinson I, Rahman N, Frayling I, et al., 1999, Inherited susceptibility to colorectal adenomas and carcinomas: Evidence for a new predisposition gene on 15q14-q22, GASTROENTEROLOGY, Vol: 116, Pages: 789-795, ISSN: 0016-5085
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- Citations: 74
Hardman C, Fry L, Tatham A, et al., 1999, Absence of toxicity of avenin in patients with dermatitis herpetiformis, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 340, Pages: 321-321, ISSN: 0028-4793
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- Citations: 14
Thomas HJW, 1998, Genetic instability in colorectal cancer, GUT, Vol: 43, Pages: 450-450, ISSN: 0017-5749
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- Citations: 3
Thomas HJ, 1998, Genetic instability in colorectal cancer., Gut, Vol: 43, Pages: 450-451, ISSN: 0017-5749
Frayling IM, Beck NE, Ilyas M, et al., 1998, The <i>APC</i> variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 95, Pages: 10722-10727, ISSN: 0027-8424
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- Citations: 151
Tomlinson IPM, Cole CE, Jacoby RF, et al., 1998, Hereditary mixed polyposis syndrome: Exclusion of genetic linkage to the juvenile polyposis region of chromosome 10., GASTROENTEROLOGY, Vol: 114, Pages: A691-A691, ISSN: 0016-5085
Gummett P, Walker MM, Loh V, et al., 1998, Advantages of near patient testing for <i>H-pylori</i> using infrared isotope analysis., GASTROENTEROLOGY, Vol: 114, Pages: A141-A141, ISSN: 0016-5085
Dove-Edwin I, Frayling I, Thomas HJW, 1998, I1307K <i>Adenomatous polyposis coli</i> gene mutation in colorectal cancer patients with a family history or early onset of colorectal cancer attending a family cancer clinic in London., GASTROENTEROLOGY, Vol: 114, Pages: A586-A586, ISSN: 0016-5085
Dove-Edwin I, Frayling I, Thomas HJW, 1998, I1307K <i>Adenomatous Polyposis Coli</i> gene mutation in colorectal cancer patients with a family history or early onset of colorectal cancer attending a family cancer clinic, GUT, Vol: 42, Pages: A54-A54, ISSN: 0017-5749
Tomlinson IPM, Cole CE, Jacoby RF, et al., 1998, Hereditary mixed polyposis syndrome: Exclusion of genetic linkage to the juvenile polyposis region of chromosome, GUT, Vol: 42, Pages: A91-A91, ISSN: 0017-5749
Gummett P, Walker MM, Loh V, et al., 1998, Advantages of near patient testing for <i>H-pylori</i> using infra-red isotope analysis, GUT, Vol: 42, Pages: A81-A81, ISSN: 0017-5749
Hardman CMJ, Garioch JJ, Leonard JN, et al., 1997, Absence of toxicity of oats in patients with dermatitis herpetiformis, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 337, Pages: 1884-1887, ISSN: 0028-4793
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- Citations: 104
Whitelaw SC, Murday VA, Tomlinson IPM, et al., 1997, Clinical and molecular features of the hereditary mixed polyposis syndrome, GASTROENTEROLOGY, Vol: 112, Pages: 327-334, ISSN: 0016-5085
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- Citations: 95
Thomas HJ, Whitelaw SC, Cottrell SE, et al., 1996, Genetic mapping of hereditary mixed polyposis syndrome to chromosome 6q., Am J Hum Genet, Vol: 58, Pages: 770-776, ISSN: 0002-9297
Hereditary mixed polyposis syndrome (HMPS) is characterized by atypical juvenile polyps, colonic adenomas, and colorectal carcinomas. HMPS appears to be inherited in an autosomal dominant manner. Genetic linkage analysis has been performed on a large family with HMPS. Data did not support linkage to the APC locus or to any of the loci for hereditary nonpolyposis colorectal cancer. Evidence that the HMPS locus lies on chromosome 6q was, however, provided by significant two-point LOD scores for linkage between HMPS and the D6S283 locus. Analysis of recombinants and multipoint linkage analysis suggested that the HMPS locus lies in a 4-cM interval containing the D6S283 locus and flanked by markers D6S468 and D6S301.
Thomas HJW, Whitelaw SC, Cottrell SE, et al., 1996, Hereditary mixed polyposis syndrome: Genetic mapping to chromosome, GASTROENTEROLOGY, Vol: 110, Pages: A602-A602, ISSN: 0016-5085
Thomas HJW, Whitelaw SC, Cottrell SE, et al., 1996, Mapping of the hereditary mixed polyposis syndrome to chromosome 6q, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 58, Pages: 770-776, ISSN: 0002-9297
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- Citations: 62
GARIOCH JJ, BAKER BS, TEARE J, et al., 1995, AN IMMUNOHISTOCHEMICAL STUDY OF INTERFERON-GAMMA, INTERLEUKIN-2 AND INTERLEUKIN-4 IN THE SMALL-INTESTINE OF PATIENTS WITH DERMATITIS-HERPETIFORMIS, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 105, Pages: 515-515, ISSN: 0022-202X
THOMAS HJW, COTTRELL S, WHITELAW S, et al., 1994, GENETIC-LINKAGE IN A PEDIGREE WITH HEREDITARY MIXED POLYPOSIS SYNDROME, GASTROENTEROLOGY, Vol: 106, Pages: A445-A445, ISSN: 0016-5085
Thomas HJ, 1993, Familial colorectal cancer., BMJ, Vol: 307, Pages: 277-278, ISSN: 0959-8138
THOMAS HJW, 1993, FAMILIAL COLORECTAL-CANCER, BRITISH MEDICAL JOURNAL, Vol: 307, Pages: 277-278, ISSN: 0959-8138
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- Citations: 23
Ward JR, Cottrell S, Thomas HJ, et al., 1993, A long-range restriction map of human chromosome 5q21-q23., Genomics, Vol: 17, Pages: 15-24, ISSN: 0888-7543
A long-range restriction map encompassing the APC (adenomatous polyposis coli) gene has been constructed. The map includes 35 DNA markers and consists of two segments of 10 and 2.5 Mb. Published genetic markers have been connected using additional, nonpolymorphic DNA probes. The map clarifies marker order and allows comparison of physical and genetic data.
WARD JRT, COTTRELL S, THOMAS HJW, et al., 1993, A LONG-RANGE RESTRICTION MAP OF HUMAN CHROMOSOME-5Q21-Q23, GENOMICS, Vol: 17, Pages: 15-24, ISSN: 0888-7543
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- Citations: 8
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