Publications
137 results found
East JE, Suzuki N, Stavrinidis M, et al., 2007, Narrow band imaging (NBI) for colonoscopic surveillance in hereditary non-polyposis colorectal cancer (HNPCC) syndrome: A back-to-back study, Digestive Disease Weeking Meeting/ASGE Postgraduate Course Meeting, Publisher: MOSBY-ELSEVIER, Pages: AB126-AB126, ISSN: 0016-5107
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- Citations: 2
Geary J, Thomas HJW, Mackay J, et al., 2007, The management of families affected by hereditary non-polyposis colorectal cancer (HNPCC), FAMILIAL CANCER, Vol: 6, Pages: 13-19, ISSN: 1389-9600
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- Citations: 10
Thirlwell C, Howarth KM, Segditsas S, et al., 2007, Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations., Br J Cancer, Vol: 96, Pages: 1729-1734
Kemp Z, Carvajal-Carmona L, Spain S, et al., 2006, Evidence for a colorectal cancer susceptibility locus on chromosome 3q21-q24 from a high-density SNP genome-wide linkage scan, HUMAN MOLECULAR GENETICS, Vol: 15, Pages: 2903-2910, ISSN: 0964-6906
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- Citations: 49
Dove-Edwin I, De Jong AE, Adams J, et al., 2006, Prospective results of surveillance colonoscopy in dominant familial colorectal cancer with and without Lynch syndrome, GASTROENTEROLOGY, Vol: 130, Pages: 1995-2000, ISSN: 0016-5085
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- Citations: 55
Kemp ZE, Carvajal-Carmona LG, Barclay E, et al., 2006, Evidence of linkage to chromosome 9q22.33 in colorectal cancer kindreds from the United Kingdom, CANCER RESEARCH, Vol: 66, Pages: 5003-5006, ISSN: 0008-5472
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- Citations: 44
Hoare JM, MacDonald D, Siddiqui A, et al., 2006, Peptic ulcers are being undertreated due to the lack of availability of specialist nursing and equipment out of hours: An audit of 116 consecutive referrals for GI bleeding, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A90-A91, ISSN: 0017-5749
Dove-Edwin I, Sasieni P, Adams J, et al., 2005, Prevention of colorectal cancer by colonoscopic surveillance in individuals with a family history of colorectal cancer: 16 year, prospective, follow-up study, BMJ-BRITISH MEDICAL JOURNAL, Vol: 331, Pages: 1047-1049, ISSN: 1756-1833
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- Citations: 152
Johnson V, Lipton LR, Cummings C, et al., 2005, Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families, JOURNAL OF MEDICAL GENETICS, Vol: 42, Pages: 756-762, ISSN: 0022-2593
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- Citations: 13
Robinson JP, Johnson VL, Rogers PA, et al., 2005, Evidence for an association between compound heterozygosity for germ line mutations in the Hemochromatosis (<i>HFE</i>) gene and increased risk of colorectal cancer, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 14, Pages: 1460-1463, ISSN: 1055-9965
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- Citations: 24
Lipton LR, Johnson V, Cummings C, et al., 2004, Refining the Amsterdam criteria and Bethesda guidelines: Testing algorithms for the prediction of mismatch repair mutation status in the familial cancer clinic, JOURNAL OF CLINICAL ONCOLOGY, Vol: 22, Pages: 4934-4943, ISSN: 0732-183X
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- Citations: 73
Brodersen NH, Sutton S, Goff S, et al., 2004, Anticipated reactions to genetic testing for hereditary non-polyposis colorectal cancer susceptibility, CLINICAL GENETICS, Vol: 66, Pages: 437-444, ISSN: 0009-9163
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- Citations: 14
Lipton L, Halford SE, Johnson V, et al., 2003, Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway, CANCER RESEARCH, Vol: 63, Pages: 7595-7599, ISSN: 0008-5472
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- Citations: 173
Lipton L, Fleischmann C, Sieber OA, et al., 2003, Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma, CANCER LETTERS, Vol: 200, Pages: 149-152, ISSN: 0304-3835
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- Citations: 23
Thomas HJW, Dove-Edwin I, Goff S, et al., 2003, The outcome of endometrial carcinoma surveillance by ultrasound scan in women at risk of hereditary nonpolyposis colorectal carcinoma and familial colorectal carcinoma - Author reply, CANCER, Vol: 98, Pages: 1773-1774, ISSN: 0008-543X
Crabtree M, Sieber OM, Lipton L, et al., 2003, Refining the relation between 'first hits' and 'second hits' at the <i>APC</i> locus:: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients, ONCOGENE, Vol: 22, Pages: 4257-4265, ISSN: 0950-9232
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- Citations: 81
Jaeger EEM, Woodford-Richens KL, Lockett M, et al., 2003, An ancestral Ashkenazi haplotype at the <i>HMPS/CRAC1</i> locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 72, Pages: 1261-1267, ISSN: 0002-9297
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- Citations: 74
Halford SER, Rowan AJ, Lipton L, et al., 2003, Germline mutations but not somatic changes at the <i>MYH</i> locus contribute to the pathogenesis of unselected colorectal cancers, AMERICAN JOURNAL OF PATHOLOGY, Vol: 162, Pages: 1545-1548, ISSN: 0002-9440
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- Citations: 97
Laiho P, Hienonen T, Karhu A, et al., 2003, Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases, ONCOGENE, Vol: 22, Pages: 2206-2214, ISSN: 0950-9232
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- Citations: 13
Sieber OM, Lipton L, Jones S, et al., 2003, Truncating and missense germ line mutations in MYH are a frequent cause of a specific multiple colorectal adenoma phenotype, Annual meeting of the British-Society-of-Gastroenterology, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: A29-A29, ISSN: 0017-5749
Lipton L, Sieber OM, Thomas HJW, et al., 2003, Germline mutations in the TGF-β and Wnt signalling pathways are a rare cause of the "multiple" adenoma phenotype -: art. no. e35, JOURNAL OF MEDICAL GENETICS, Vol: 40, ISSN: 0022-2593
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- Citations: 15
Dove-Edwin I, Sasieni P, Adams J, et al., 2003, The prevention of colorectal cancer by colonoscopic surveillance in individuals with a family history of colorectal cancer, Annual meeting of the British-Society-of-Gastroenterology, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: A30-A31, ISSN: 0017-5749
Lipton L, Sieber OM, Crabtree M, et al., 2003, Multiple colorectal adenomas, familial adenomatous polyposis and germline mutations in MYH, Digestive Disease Week 2003 Meeting/104th Annual Meeting of the American-Gastroenterological-Association, Publisher: W B SAUNDERS CO, Pages: A45-A45, ISSN: 0016-5085
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- Citations: 1
Sieber OM, Lipton L, Crabtree M, et al., 2003, Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH., New England Journal of Medicine, Vol: 348, Pages: 791-799
Brooker JC, Saunders BP, Shah SG, et al., 2002, Total colonic dye-spray increases the detection of diminutive adenomas during routine colonoscopy: a randomized controlled trial, GASTROINTESTINAL ENDOSCOPY, Vol: 56, Pages: 333-338, ISSN: 0016-5107
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- Citations: 229
Dove-Edwin I, Boks D, Goff S, et al., 2002, The outcome of endometrial carcinoma surveillance by ultrasound scan in women at risk of hereditary nonpolyposis colorectal carcinoma and familial colorectal carcinoma, 8th Biennial Meeting of the Leeds-Castle-Polyposis-Group, Publisher: JOHN WILEY & SONS INC, Pages: 1708-1712, ISSN: 0008-543X
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- Citations: 156
Dove-Edwin I, Boks D, Goff S, et al., 2002, The outcome of endometrial carcinoma surveillance by ultrasound scan in women at risk of hereditary nonpolyposis colorectal carcinoma and familial colorectal carcinoma., Cancer, Vol: 94, Pages: 1708-1712, ISSN: 0008-543X
BACKGROUND: Endometrial carcinoma is the most common extracolonic malignancy associated with hereditary nonpolyposis colorectal carcinoma syndrome (HNPCC). The risk of endometrial carcinoma in HNPCC mutation carriers is approximately ten times that of the general population, and endometrial ultrasound surveillance to detect early cancer in asymptomatic individuals is recommended by the International Collaborative Group on HNPCC. There is little, if any, published data addressing the effectiveness of surveillance in HNPCC and familial colorectal carcinoma. METHODS: The outcomes of endometrial carcinoma surveillance scans were collected from the St Mark's Hospital Imperial Cancer Research Fund Family Cancer Clinic in the UK and the Netherlands Foundation for the Detection of Hereditary Tumors. Two hundred ninety two women from HNPCC (171) or HNPCC-like (98) families between the ages of 25-65 years were offered pelvic ultrasound surveillance scans for a period of up to 13 years. RESULTS: Results were available from 269 women. The study period included a total of 825.7 years of risk. Two cases of endometrial carcinoma were reported. Neither case was detected by surveillance scanning. Both cases presented at an early stage with symptoms and were subsequently cured. CONCLUSIONS: Endometrial carcinoma surveillance in hereditary colorectal carcinoma may not offer obvious clinical benefits.
Sieber OM, Lamlum H, Crabtree MD, et al., 2002, Whole-gene <i>APC</i> deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 99, Pages: 2954-2958, ISSN: 0027-8424
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- Citations: 97
Dove-Edwin I, Williams CB, Sasieni P, et al., 2001, Familiar colorectal cancer: The outcome of colonoscopic surveillance in (dominant) HNPCC and non-HNPCC families., GASTROENTEROLOGY, Vol: 120, Pages: A742-A742, ISSN: 0016-5085
Dove-Edwin I, Thomas HJW, 2001, Review article: The prevention of colorectal cancer, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 15, Pages: 323-336, ISSN: 0269-2813
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- Citations: 29
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