Imperial College London
Professor Sir Huw Thomas

Professor Sir Huw Thomas

Faculty of Medicine, Department of Surgery & Cancer

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 8235 4266huw.thomas

 
 
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Location

 

St Marks HospitalNorthwick Park and St Marks Site

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Summary

 

Publications

Citation

BibTex format

@article{Movahedi:2015:10.1200/JCO.2014.58.9952,
author = {Movahedi, M and Bishop, DT and Macrae, F and Mecklin, J-P and Moeslein, G and Olschwang, S and Eccles, D and Evans, DG and Maher, ER and Bertario, L and Bisgaard, M-L and Dunlop, MG and Ho, JWC and Hodgson, SV and Lindblom, A and Lubinski, J and Morrison, PJ and Murday, V and Ramesar, RS and Side, L and Scott, RJ and Thomas, HJW and Vasen, HF and Burn, J and Mathers, JC},
doi = {10.1200/JCO.2014.58.9952},
journal = {Journal of Clinical Oncology},
pages = {3591--3597},
title = {Obesity, aspirin, and risk of colorectal cancer in carriers of hereditary colorectal cancer: a prospective investigation in the CAPP2 study},
url = {http://dx.doi.org/10.1200/JCO.2014.58.9952},
volume = {33},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PurposeIn the general population, increased adiposity is a significant risk factor for colorectal cancer (CRC), but whether obesity has similar effects in those with hereditary CRC is uncertain. This prospective study investigated the association between body mass index and cancer risk in patients with Lynch syndrome (LS).Patients and MethodsParticipants with LS were recruited to the CAPP2 study, in which they were randomly assigned to receive aspirin 600 mg per day or aspirin placebo, plus resistant starch 30 g per day or starch placebo (2 × 2 factorial design). Mean intervention period was 25.0 months, and mean follow-up was 55.7 months.ResultsDuring follow-up, 55 of 937 participants developed CRC. For obese participants, CRC risk was 2.41× (95% CI, 1.22 to 4.85) greater than for underweight and normal-weight participants (reference group), and CRC risk increased by 7% for each 1-kg/m2 increase in body mass index. The risk of all LS-related cancers in obese people was 1.77× (95% CI, 1.06 to 2.96; P = .03) greater than for the reference group. In subgroup analysis, obesity was associated with 3.72× (95% CI, 1.41 to 9.81) greater CRC risk in patients with LS with MLH1 mutation, but no excess risk was observed in those with MSH2 or MSH6 mutation (P = .5). The obesity-related excess CRC risk was confined to those randomly assigned to the aspirin placebo group (adjusted hazard ratio, 2.75; 95% CI, 1.12 to 6.79; P = .03).ConclusionObesity is associated with substantially increased CRC risk in patients with LS, but this risk is abrogated in those taking aspirin. Such patients are likely to benefit from obesity prevention and/or regular aspirin.
AU  - Movahedi,M
AU  - Bishop,DT
AU  - Macrae,F
AU  - Mecklin,J-P
AU  - Moeslein,G
AU  - Olschwang,S
AU  - Eccles,D
AU  - Evans,DG
AU  - Maher,ER
AU  - Bertario,L
AU  - Bisgaard,M-L
AU  - Dunlop,MG
AU  - Ho,JWC
AU  - Hodgson,SV
AU  - Lindblom,A
AU  - Lubinski,J
AU  - Morrison,PJ
AU  - Murday,V
AU  - Ramesar,RS
AU  - Side,L
AU  - Scott,RJ
AU  - Thomas,HJW
AU  - Vasen,HF
AU  - Burn,J
AU  - Mathers,JC
DO  - 10.1200/JCO.2014.58.9952
EP  - 3597
PY  - 2015///
SN  - 0732-183X
SP  - 3591
TI  - Obesity, aspirin, and risk of colorectal cancer in carriers of hereditary colorectal cancer: a prospective investigation in the CAPP2 study
T2  - Journal of Clinical Oncology
UR  - http://dx.doi.org/10.1200/JCO.2014.58.9952
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000366019800015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://ascopubs.org/doi/10.1200/JCO.2014.58.9952
VL  - 33
ER  -
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