DrIrosBarozzi

Faculty of Medicine, Department of Surgery & Cancer

Imperial College Research Fellow

Contact

Location

ICTEM buildingHammersmith Campus

Summary

Imperial College Research Fellow interested in Cancer Regulatory Genomics (see Research for more details). MSc projects available to students in any quantitative biology discipline, and to students in computer science with a strong interest in Genomics.

Selected Publications

Journal Articles

Hong SP, Lombardo Y, Chan TE, et al.Hong SP, Lombardo Y, Chan TE, Corleone G, Rotmensz N, Magnani L, Bravaccini S, Rocca A, Pruneri G, McEwen KR, Coombes RC, Barozzi I close, 2019, Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy, Nature Communications, Vol:10, ISSN:2041-1723

Comoglio F, Simonatto M, Polletti S, et al.Comoglio F, Simonatto M, Polletti S, Liu X, Smale ST, Barozzi I, Natoli G close, 2019, Dissection of acute stimulus-inducible nucleosome remodeling in mammalian cells, Genes & Development, Vol:33, ISSN:0890-9369, Pages:1159-1174

Oz-Levi D, Olender T, Bar-Joseph I, et al.Oz-Levi D, Olender T, Bar-Joseph I, Zhu Y, Marek-Yagel D, Barozzi I, Osterwalder M, Alkelai A, Ruzzo EK, Han Y, Vos ESM, Reznik-Wolf H, Hartman C, Shamir R, Weiss B, Shapiro R, Pode-Shakked B, Tatarskyy P, Milgrom R, Schvimer M, Barshack I, Imai DM, Coleman-Derr D, Dickel DE, Nord AS, Afzal V, van Bueren KL, Barnes RM, Black BL, Mayhew CN, Kuhar MF, Pitstick A, Tekman M, Stanescu HC, Wells JM, Kleta R, de Laat W, Goldstein DB, Pras E, Visel A, Lancet D, Anikster Y, Pennacchio LA close, 2019, Noncoding deletions reveal a gene that is critical for intestinal function., Nature, Vol:571, Pages:107-111

Osterwalder M, Barozzi I, Tissières V, et al.Osterwalder M, Barozzi I, Tissières V, Fukuda-Yuzawa Y, Mannion BJ, Afzal SY, Lee EA, Zhu Y, Plajzer-Frick I, Pickle CS, Kato M, Garvin TH, Pham QT, Harrington AN, Akiyama JA, Afzal V, Lopez-Rios J, Dickel DE, Visel A, Pennacchio LA close, 2018, Enhancer redundancy provides phenotypic robustness in mammalian development, Nature, Vol:554, ISSN:0028-0836, Pages:239-243

Monti R, Barozzi I, Osterwalder M, et al.Monti R, Barozzi I, Osterwalder M, Lee E, Kato M, Garvin TH, Plajzer-Frick I, Pickle CS, Akiyama JA, Afzal V, Beerenwinkel N, Dickel DE, Visel A, Pennacchio LA close, 2017, Limb-Enhancer Genie: An accessible resource of accurate enhancer predictions in the developing limb, Plos Computational Biology, Vol:13, Pages:e1005720-e1005720

Sheth R, Barozzi I, Langlais D, et al.Sheth R, Barozzi I, Langlais D, Osterwalder M, Nemec S, Carlson HL, Stadler HS, Visel A, Drouin J, Kmita M close, 2016, Distal Limb Patterning Requires Modulation of cis -Regulatory Activities by HOX13, Cell Reports, Vol:17, ISSN:2211-1247, Pages:2913-2926

Nguyen VTM, Barozzi I, Faronato M, et al.Nguyen VTM, Barozzi I, Faronato M, Lombardo Y, Steel JH, Patel N, Darbre P, Castellano L, Gyorffy B, Woodley L, Meira A, Patten DL, Vircillo V, Periyasamy M, Ali S, Frige G, Minucci S, Coombes RC, Magnani L close, 2015, Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion, Nature Communications, Vol:6, ISSN:2041-1723

Austenaa LMI, Barozzi I, Simonatto M, et al.Austenaa LMI, Barozzi I, Simonatto M, Masella S, Della Chiara G, Ghisletti S, Curina A, de Wit E, Bouwman BAM, de Pretis S, Piccolo V, Termanini A, Prosperini E, Pelizzola M, de Laat W, Natoli G close, 2015, Transcription of Mammalian cis-Regulatory Elements Is Restrained by Actively Enforced Early Termination, Molecular Cell, Vol:60, ISSN:1097-2765, Pages:460-474

Barozzi I, Simonatto M, Bonifacio S, et al.Barozzi I, Simonatto M, Bonifacio S, Yang L, Rohs R, Ghisletti S, Natoli G close, 2014, Coregulation of Transcription Factor Binding and Nucleosome Occupancy through DNA Features of Mammalian Enhancers, Molecular Cell, Vol:54, ISSN:1097-2765, Pages:844-857

Ostuni R, Piccolo V, Barozzi I, et al.Ostuni R, Piccolo V, Barozzi I, Polletti S, Termanini A, Bonifacio S, Curina A, Prosperini E, Ghisletti S, Natoli G close, 2013, Latent Enhancers Activated by Stimulation in Differentiated Cells, Cell, Vol:152, ISSN:0092-8674, Pages:157-171

De Santa F, Barozzi I, Mietton F, et al.De Santa F, Barozzi I, Mietton F, Ghisletti S, Polletti S, Tusi BK, Muller H, Ragoussis J, Wei C-L, Natoli G close, A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers, Plos Biology, Vol:8, Pages:e1000384-e1000384

Ghisletti S, Barozzi I, Mietton F, et al.Ghisletti S, Barozzi I, Mietton F, Polletti S, De Santa F, Venturini E, Gregory L, Lonie L, Chew A, Wei C-L, Ragoussis J, Natoli G close, 2010, Identification and Characterization of Enhancers Controlling the Inflammatory Gene Expression Program in Macrophages, Immunity, Vol:32, ISSN:1074-7613, Pages:317-328

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