Imperial College London
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DrIlariaDorigatti

Faculty of Medicine, School of Public Health

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 1451i.dorigatti

 
 
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Location

 

G24Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Manuto:2022:10.3390/v14020399,
author = {Manuto, L and Grazioli, M and Spitaleri, A and Fontana, P and Bianco, L and Bertolotti, L and Bado, M and Mazzotti, G and Bianca, F and Onelia, F and Lorenzin, G and Simeoni, F and Lazarevic, D and Franchin, E and Vecchio, CD and Dorigatti, I and Tonon, G and Cirillo, DM and Lavezzo, E and Crisanti, A and Toppo, S},
doi = {10.3390/v14020399},
journal = {Viruses},
pages = {1--14},
title = {Rapid SARS-CoV-2 intra-host and within-household emergence of novel haplotypes},
url = {http://dx.doi.org/10.3390/v14020399},
volume = {14},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In February 2020, the municipality of Vo’, a small town near Padua (Italy) was quarantined due to the first coronavirus disease 19 (COVID-19)-related death detected in Italy. To investigate the viral prevalence and clinical features, the entire population was swab tested in two sequential surveys. Here we report the analysis of 87 viral genomes, which revealed that the unique ancestor haplotype introduced in Vo’ belongs to lineage B, carrying the mutations G11083T and G26144T. The viral sequences allowed us to investigate the viral evolution while being transmitted within and across households and the effectiveness of the non-pharmaceutical interventions implemented in Vo’. We report, for the first time, evidence that novel viral haplotypes can naturally arise intra-host within an interval as short as two weeks, in approximately 30% of the infected individuals, regardless of symptom severity or immune system deficiencies. Moreover, both phylogenetic and minimum spanning network analyses converge on the hypothesis that the viral sequences evolved from a unique common ancestor haplotype that was carried by an index case. The lockdown extinguished both the viral spread and the emergence of new variants.
AU  - Manuto,L
AU  - Grazioli,M
AU  - Spitaleri,A
AU  - Fontana,P
AU  - Bianco,L
AU  - Bertolotti,L
AU  - Bado,M
AU  - Mazzotti,G
AU  - Bianca,F
AU  - Onelia,F
AU  - Lorenzin,G
AU  - Simeoni,F
AU  - Lazarevic,D
AU  - Franchin,E
AU  - Vecchio,CD
AU  - Dorigatti,I
AU  - Tonon,G
AU  - Cirillo,DM
AU  - Lavezzo,E
AU  - Crisanti,A
AU  - Toppo,S
DO  - 10.3390/v14020399
EP  - 14
PY  - 2022///
SN  - 1999-4915
SP  - 1
TI  - Rapid SARS-CoV-2 intra-host and within-household emergence of novel haplotypes
T2  - Viruses
UR  - http://dx.doi.org/10.3390/v14020399
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000762301900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.mdpi.com/1999-4915/14/2/399
UR  - http://hdl.handle.net/10044/1/105755
VL  - 14
ER  -
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