Imperial College London
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DrIlariaDorigatti

Faculty of Medicine, School of Public Health

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 1451i.dorigatti

 
 
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Location

 

G24Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Del:2022:10.1038/s41467-022-33460-0,
author = {Del, Vecchio C and Cracknell, Daniels B and Brancaccio, G and Brazzale, AR and Lavezzo, E and Ciavarella, C and Onelia, F and Franchin, E and Manuto, L and Bianca, F and Cianci, V and Cattelan, AM and Dorigatti, I and Toppo, S and Crisanti, A},
doi = {10.1038/s41467-022-33460-0},
journal = {Nature Communications},
pages = {1--16},
title = {Impact of antigen test target failure and testing strategies on the transmission of SARS-CoV-2 variants},
url = {http://dx.doi.org/10.1038/s41467-022-33460-0},
volume = {13},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Population testing remains central to COVID-19 control and surveillance, with countries increasingly using antigen tests rather than molecular tests. Here we describe a SARS-CoV-2 variant that escapes N antigen tests due to multiple disruptive amino-acid substitutions in the N protein. By fitting a multistrain compartmental model to genomic and epidemiological data, we show that widespread antigen testing in the Italian region of Veneto favored the undetected spread of the antigen-escape variant compared to the rest of Italy. We highlight novel limitations of widespread antigen testing in the absence of molecular testing for diagnostic or confirmatory purposes. Notably, we find that genomic surveillance systems which rely on antigen population testing to identify samples for sequencing will bias detection of escape antigen test variants. Together, these findings highlight the importance of retaining molecular testing for surveillance purposes, including in contexts where the use of antigen tests is widespread.
AU  - Del,Vecchio C
AU  - Cracknell,Daniels B
AU  - Brancaccio,G
AU  - Brazzale,AR
AU  - Lavezzo,E
AU  - Ciavarella,C
AU  - Onelia,F
AU  - Franchin,E
AU  - Manuto,L
AU  - Bianca,F
AU  - Cianci,V
AU  - Cattelan,AM
AU  - Dorigatti,I
AU  - Toppo,S
AU  - Crisanti,A
DO  - 10.1038/s41467-022-33460-0
EP  - 16
PY  - 2022///
SN  - 2041-1723
SP  - 1
TI  - Impact of antigen test target failure and testing strategies on the transmission of SARS-CoV-2 variants
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-022-33460-0
UR  - https://www.nature.com/articles/s41467-022-33460-0
UR  - http://hdl.handle.net/10044/1/100092
VL  - 13
ER  -
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