Imperial College London
Alternate

DrIsabelGarcia Perez

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer in Precision and Systems Medicine
 
 
 
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Contact

 

i.garcia-perez

 
 
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Location

 

101Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lloyd:2019:10.1007/s11306-019-1532-3,
author = {Lloyd, AJ and Willis, ND and Wilson, T and Zubair, H and Chambers, E and Garcia-Perez, I and Xie, L and Tailliart, K and Beckmann, M and Mathers, JC and Draper, J},
doi = {10.1007/s11306-019-1532-3},
journal = {Metabolomics},
title = {Addressing the pitfalls when designing intervention studies to discover and validate biomarkers of habitual dietary intake},
url = {http://dx.doi.org/10.1007/s11306-019-1532-3},
volume = {15},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IntroductionDietary exposure monitoring within populations is reliant on self-reported measures such as Food Frequency Questionnaires and diet diaries. These methods often contain inaccurate information due to participant misreporting, non-compliance and bias. Urinary metabolites derived from individual foods could provide additional objective indicators of dietary exposure. For biomarker approaches to have utility it is essential that they cover a wide-range of commonly consumed foods and the methodology works in a real-world environment.ObjectivesTo test that the methodology works in a real-world environment and to consider the impact of the major sources of likely variance; particularly complex meals, different food formulations, processing and cooking methods, as well as the dynamics of biomarker duration in the body.MethodsWe designed and tested a dietary exposure biomarker discovery and validation strategy based on a food intervention study involving free-living individuals preparing meals and collecting urine samples at home. Two experimental periods were built around three consecutive day menu plans where all foods and drinks were provided (n = 15 and n = 36).ResultsThe experimental design was validated by confirming known consumption biomarkers in urinary samples after the first menu plan. We tested biomarker performance with different food formulations and processing methods involving meat, wholegrain, fruits and vegetables.ConclusionIt was demonstrated that spot urine samples, together with robust dietary biomarkers, despite major sources of variance, could be used successfully for dietary exposure monitoring in large epidemiological studies.
AU  - Lloyd,AJ
AU  - Willis,ND
AU  - Wilson,T
AU  - Zubair,H
AU  - Chambers,E
AU  - Garcia-Perez,I
AU  - Xie,L
AU  - Tailliart,K
AU  - Beckmann,M
AU  - Mathers,JC
AU  - Draper,J
DO  - 10.1007/s11306-019-1532-3
PY  - 2019///
SN  - 1573-3882
TI  - Addressing the pitfalls when designing intervention studies to discover and validate biomarkers of habitual dietary intake
T2  - Metabolomics
UR  - http://dx.doi.org/10.1007/s11306-019-1532-3
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000466947200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/70940
VL  - 15
ER  -
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