Imperial College London
Alternate

DrIanGodsland

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Wynn Reader in Human Metabolism
 
 
 
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Contact

 

+44 (0)20 3312 6573i.godsland

 
 
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Assistant

 

Mrs Heather Bones +44 (0)20 7594 2429

 
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Location

 

Room G1Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

342 results found

CROOK D, GODSLAND IF, WYNN V, 1992, CHOLESTEROL, APOLIPOPROTEINS, AND THE RISK OF MYOCARDIAL-INFARCTION, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 326, Pages: 490-491, ISSN: 0028-4793

Journal article

Crook D, Godsland IF, Wynn V, 1992, Cholesterol, apolipoproteins, and the risk of myocardial infarction., N Engl J Med, Vol: 326, Pages: 490-491, ISSN: 0028-4793

Journal article

BRUCE R, GODSLAND I, STEVENSON J, DEVENPORT M, BORTH F, CROOK D, GHATEI M, WHITEHEAD M, WYNN Vet al., 1992, DANAZOL INDUCES RESISTANCE TO BOTH INSULIN AND GLUCAGON IN YOUNG-WOMEN, CLINICAL SCIENCE, Vol: 82, Pages: 211-217, ISSN: 0143-5221

Journal article

GODSLAND IF, WALTON C, FELTON C, PROUDLER A, PATEL A, WYNN Vet al., 1992, INSULIN RESISTANCE, SECRETION, AND METABOLISM IN USERS OF ORAL-CONTRACEPTIVES, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 74, Pages: 64-70, ISSN: 0021-972X

Journal article

GODSLAND IF, OLIVER MF, 1991, SYNDROME(S)-X, LANCET, Vol: 337, Pages: 916-916, ISSN: 0140-6736

Journal article

CROOK D, MONTGOMERY JC, GODSLAND IF, DEVENPORT M, MARENAH CB, STUDD JWW, WYNN Vet al., 1991, LIPID AND CARBOHYDRATE-METABOLISM IN PREMENOPAUSAL WOMEN GIVEN SUBDERMAL ESTRADIOL IMPLANTS, HORMONE AND METABOLIC RESEARCH, Vol: 23, Pages: 174-177, ISSN: 0018-5043

Journal article

GODSLAND IF, CROOK D, WYNN V, 1991, CORONARY HEART-DISEASE RISK MARKERS IN USERS OF LOW-DOSE ORAL-CONTRACEPTIVES, JOURNAL OF REPRODUCTIVE MEDICINE, Vol: 36, Pages: 226-237, ISSN: 0024-7758

Journal article

Crook D, Godsland IF, Wynn V, 1991, Oral contraceptives and metabolic risk markers for coronary heart disease., Int J Fertil, Vol: 36 Suppl 1, Pages: 38-46, ISSN: 0020-725X

Disturbances in both the plasma lipid profile and in insulin handling have been implicated in the development of coronary heart disease (CHD). Estrogens and progestins are known to affect significantly both lipid and insulin metabolism. Since an increased incidence of myocardial infarction has been identified among users of oral contraceptives (OCs), the metabolic effect of these drugs on risk factors for CHD is of interest. Comparison of a range of monophasic and triphasic OCs that differ primarily in their progestin content has shown that lowering the progestin dose and using a less androgenic steroid reduce the impact on both low-density lipoproteins and high-density lipoproteins (HDLs). In terms of the HDL-2 subfraction, a lipoprotein class that may be of special relevance to the development of CHD, low-dose norethindrone and desogestrel monophasic agents had the least adverse effect. Triglyceride levels were increased by the low-dose OCs used in this study; this may be an unavoidable consequence of current trends in OC development. However, the clinical significance of these increased triglyceride levels is not clear. Glucose tolerance deteriorated similarly with all the formulations in this study, although the effect on insulin concentrations was less marked with formulations containing lower doses of progestins. It was concluded that reducing the progestin dose and changing the progestin type effectively reduce the adverse impact of OCs on metabolic risk for CHD. Although further study is recommended, the use of OC formulations without adverse effects on risk profile is indicated.

Journal article

GODSLAND IF, CROOK D, SIMPSON R, PROUDLER T, FELTON C, LEES B, ANYAOKU V, DEVENPORT M, WYNN Vet al., 1990, THE EFFECTS OF DIFFERENT FORMULATIONS OF ORAL-CONTRACEPTIVE AGENTS ON LIPID AND CARBOHYDRATE-METABOLISM, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 323, Pages: 1375-1381, ISSN: 0028-4793

Journal article

STEVENSON JC, GODSLAND IF, BRUCE R, WYNN Vet al., 1990, OBESITY AND RISK OF CORONARY HEART-DISEASE IN WOMEN, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 323, Pages: 1143-1144, ISSN: 0028-4793

Journal article

WYNN V, GODSLAND I, WALTON C, 1990, CAN LIFE-STYLE CHANGES REVERSE CORONARY HEART-DISEASE, LANCET, Vol: 336, Pages: 624-625, ISSN: 0140-6736

Journal article

GODSLAND IF, CROOK D, WYNN V, 1990, LOW-DOSE ORAL-CONTRACEPTIVES AND CARBOHYDRATE-METABOLISM, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, Vol: 163, Pages: 348-353, ISSN: 0002-9378

Journal article

WYNN V, GODSLAND IF, STEVENSON JC, 1990, MORTALITY AMONG ORAL-CONTRACEPTIVE USERS, BRITISH MEDICAL JOURNAL, Vol: 300, Pages: 331-331, ISSN: 0959-8138

Journal article

MONTGOMERY JC, CROOK D, GODSLAND IF, WYNN V, STUDD JWWet al., 1989, PLASMA-LIPID RISK-FACTORS IN OOPHORECTOMIZED WOMEN, BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 96, Pages: 1236-1238, ISSN: 0306-5456

Journal article

CROOK D, GODSLAND IF, WYNN V, 1989, HDL AS AN INDEPENDENT RISK FACTOR IN BRITISH MEN (AND WOMEN), BMJ-BRITISH MEDICAL JOURNAL, Vol: 298, Pages: 1249-1249, ISSN: 1756-1833

Journal article

Crook D, Godsland IF, Wynn V, 1989, HDL as an independent risk factor in British men (and women)., BMJ, Vol: 298, ISSN: 0959-8138

Journal article

Crook D, Godsland IF, Wynn V, 1989, Lack of metabolic effects of a triphasic formulation containing norethindrone in normal women studied prospectively., Contraception, Vol: 39, Pages: 125-128, ISSN: 0010-7824

Journal article

WYNN V, GODSLAND I, SIMPSON R, LEES B, PROUDLER T, FELTON C, ANYOKU V, CROOK Det al., 1989, CARBOHYDRATE AND LIPID-METABOLISM IN LOW-DOSE ORAL CONTRACEPTION, 12TH WORLD CONGRESS OF GYNECOLOGY AND OBSTETRICS, Publisher: PARTHENON PUBLISHING GROUP LTD, Pages: 287-298

Conference paper

GODSLAND IF, WYNN V, CROOK D, 1988, MENOPAUSE AND CORONARY-DISEASE - REPLY, AMERICAN HEART JOURNAL, Vol: 116, Pages: 1649-1649, ISSN: 0002-8703

Journal article

CROOK D, GODSLAND IF, WYNN V, 1988, ORAL-CONTRACEPTIVES AND CORONARY HEART-DISEASE - MODULATION OF GLUCOSE-TOLERANCE AND PLASMA-LIPID RISK-FACTORS BY PROGESTINS, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, Vol: 158, Pages: 1612-1620, ISSN: 0002-9378

Journal article

GODSLAND IF, WYNN V, CROOK D, MILLER NEet al., 1987, SEX, PLASMA-LIPOPROTEINS, AND ATHEROSCLEROSIS - PREVAILING ASSUMPTIONS AND OUTSTANDING QUESTIONS, AMERICAN HEART JOURNAL, Vol: 114, Pages: 1467-1503, ISSN: 0002-8703

Journal article

GODSLAND IF, WYNN V, 1987, DERIVATION OF A QUANTITATIVE MEASURE OF INSULIN SENSITIVITY FROM THE INTRAVENOUS TOLBUTAMIDE TEST USING THE MINIMAL MODEL OF GLUCOSE DYNAMICS - RESPONSE, DIABETOLOGIA, Vol: 30, Pages: 756-756, ISSN: 0012-186X

Journal article

PARR JH, SEED M, GODSLAND I, WYNN Vet al., 1987, THE EFFECTS OF REVERSE SEQUENTIAL ANTIANDROGEN THERAPY (CYPROTERONE-ACETATE AND ETHINYL ESTRADIOL) ON HEMATOLOGICAL PARAMETERS, JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, Vol: 10, Pages: 237-239, ISSN: 0391-4097

Journal article

SHENNAN NM, GODSLAND IF, WYNN V, 1987, DERIVATION OF A QUANTITATIVE MEASURE OF INSULIN SENSITIVITY FROM THE INTRAVENOUS TOLBUTAMIDE TEST USING THE MINIMAL MODEL OF GLUCOSE DYNAMICS, DIABETOLOGIA, Vol: 30, Pages: 314-322, ISSN: 0012-186X

Journal article

GODSLAND IF, SHENNAN NM, WYNN V, 1986, INSULIN ACTION AND DYNAMICS MODELED IN PATIENTS TAKING THE ANABOLIC-STEROID METHANDIENONE (DIANABOL), CLINICAL SCIENCE, Vol: 71, Pages: 665-673, ISSN: 0143-5221

Journal article

Wynn V, Godsland I, 1986, Effects of oral contraceptives on carbohydrate metabolism., J Reprod Med, Vol: 31, Pages: 892-897, ISSN: 0024-7758

Both estrogens and progestogens modify carbohydrate metabolism, and their ultimate effect depends upon the ratio of one to the other. The effect of progestogens themselves, which are responsible for increased insulin secretion and for insulin resistance, varies according to their androgenicity but increases according to the series pregnane, estrane and gonane. In contrast, estrogens impair the initial secretion of insulin by the pancreas. The prolonged use of combined oral contraceptives containing the powerful progestogen levonorgestrel is associated with mild but continuing glucose intolerance and with marked insulin resistance.

Journal article

WYNN V, GODSLAND I, 1986, EFFECTS OF ORAL-CONTRACEPTIVES ON CARBOHYDRATE-METABOLISM, JOURNAL OF REPRODUCTIVE MEDICINE, Vol: 31, Pages: 892-897, ISSN: 0024-7758

Journal article

WYNN V, CROOK D, GODSLAND IF, SEED M, SHENNAN NMet al., 1986, HIGH-DENSITY-LIPOPROTEIN IS NOT A MAJOR RISK FACTOR FOR ISCHEMIC-HEART-DISEASE IN BRITISH MEN - REPLY, BRITISH MEDICAL JOURNAL, Vol: 292, Pages: 1200-1200, ISSN: 0959-8138

Journal article

WYNN V, CROOK D, GODSLAND IF, SEED M, SHENNAN NMet al., 1986, HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL IS NOT A MAJOR RISK FACTOR FOR ISCHEMIC-HEART-DISEASE IN BRITISH MEN, BMJ-BRITISH MEDICAL JOURNAL, Vol: 292, Pages: 1013-1013, ISSN: 1756-1833

Journal article

WYNN V, GODSLAND IF, SEED M, JACOBS HSet al., 1986, PARADOXICAL EFFECTS OF THE ANTIANDROGEN CYPROTERONE-ACETATE ON LIPID AND LIPOPROTEIN METABOLISM, CLINICAL ENDOCRINOLOGY, Vol: 24, Pages: 183-191, ISSN: 0300-0664

Journal article

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