Publications
342 results found
Tan TM, Salem V, Troke RC, et al., 2014, Combination of peptide YY3-36 with GLP-1(7-36) amide causes an increase in first-phase insulin secretion after IV glucose, Journal of Clinical Endocrinology and Metabolism, Vol: 99, Pages: E2317-E2324, ISSN: 0021-972X
Context: The combination of peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) has been proposed as a potential treatment for diabetes and obesity. However, the combined effects of these hormones, PYY3–36 and GLP-17–36 amide, on glucose homeostasis are unknown.Objective: This study sought to investigate the acute effects of PYY3–36 and GLP-17–36 amide, individually and in combination, on insulin secretion and sensitivity.Setting and Design: Using a frequently sampled iv glucose tolerance test (FSIVGTT) and minimal modeling, this study measured the effects of PYY3–36 alone, GLP-17–36 amide alone, and a combination of PYY3–36 and GLP-17–36 amide on acute insulin response to glucose (AIRg) and insulin sensitivity index (SI) in 14 overweight human volunteers, studied in a clinical research facility.Results: PYY3–36 alone caused a small but nonsignificant increase in AIRg. GLP-17–36 amide alone and the combination of PYY3–36 and GLP-17–36 amide did increase AIRg significantly. No significant differences in SI were observed with any intervention.Conclusions: PYY3–36 lacks any significant acute effects on first-phase insulin secretion or SI when tested using an FSIVGTT. Both GLP-17–36 amide alone and the combination of PYY3–36 and GLP-17–36 amide increase first-phase insulin secretion. There does not seem to be any additive or synergistic effect between PYY3–36 and GLP-17–36 amide on first-phase insulin secretion. Neither hormone alone nor the combination had any significant effects on SI.
Nanditha A, Ram J, Snehalatha C, et al., 2014, Early improvement predicts reduced risk of incident diabetes and improved cardiovascular risk in prediabetic Asian Indian men participating in a 2-year lifestyle intervention program, Diabetes Care, Vol: 37, Pages: 3009-3015, ISSN: 0149-5992
OBJECTIVE Objectives of this ancillary analysis of a prospective, prevention study among Asian Indians with impaired glucose tolerance (IGT) were a) to quantify the reduction in incident diabetes at 24 months in participants who achieved normal glucose tolerance (NGT) at 6 months (NGT-6 m) compared with the other participants, b) the factors influencing the reversal to NGT at the end of the study at 24 months (NGT-24 m), and c) to assess changes in cardiometabolic risk factors in different categories of dysglycemia at 24 months.RESEARCH DESIGN AND METHODS Data from a 2-year primary prevention trial were used. Effect of reversion to NGT-6 m on incidence of type 2 diabetes mellitus (T2DM) was analyzed using the Cox proportional hazards model. Predictive variables for reversal to NGT were identified using multiple logistic regression analysis. Changes in cardiometabolic risk factors were estimated according to the final glycemic status using fixed-effect, mixed-linear regression modeling.RESULTS The risk of T2DM in 2 years was lower by 75% in NGT-6 m group (hazard ratio 0.25 [95% CI 0.12–0.52]). Predictive variables for reversal to NGT-24 m were good baseline β-cell function (odds ratio [OR] 2.79 [95% CI 2.30–3.40]) and its further improvement (OR 5.70 [95% CI 4.58–7.08]), and NGT-6 m (OR 2.10 [95% CI 1.14–3.83]). BMI decreased in those who reverted to NGT. Deterioration to T2DM was associated with an increase in the levels of cardiometabolic risk factors.CONCLUSIONS Early reversion to NGT by lifestyle intervention in prediabetic men was associated with a significant reduction in subsequent incidence of diabetes. Good baseline β-cell function and its further improvement and NGT-6 m were associated with reversion to NGT-24 months. Reversion to NGT was associated with modest improvements, whereas conversion to T2DM was associated with significant worsening of the cardiometabolic risk profile.
Bravis V, Kaur A, Walkey H, et al., 2014, Ater diagnosis diabetes research support system-2 (ADDRESS-2): clinical presentation of type 1 diabetes in the beginning of the 21st century in a multi-ethnic UK cohort, European Association for the Study of Diabetes, Publisher: SPRINGER, Pages: S127-S128, ISSN: 0012-186X
Eastwood SV, Tillin T, Wright A, et al., 2014, Thigh Fat and Muscle each Contribute to Excess Cardiometabolic Risk in South Asians, Independent of Visceral Adipose Tissue, OBESITY, Vol: 22, Pages: 2071-2079, ISSN: 1930-7381
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- Citations: 41
Bravis V, Kaur A, Walkey H, et al., 2014, An Incident and High-Risk Type 1 Diabetes Cohort-After Diagnosis Diabetes Research Support System-2 (ADDRESS-2): Key Initial Findings, Publisher: AMER DIABETES ASSOC, Pages: A645-A645, ISSN: 0012-1797
Langley RE, Truinh D, Jovic G, et al., 2014, Prostate Adenocarcinoma: TransCutaneons Hormones, PR09 (PATCH): A randomized controlled trial of transdemal estrogen patches versus luteinising hormone releasing hormone agonists in locally advanced and metastatic prostate cancer., 50th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0732-183X
Neff KJ, Chuah LL, Aasheim ET, et al., 2014, Beyond Weight Loss: Evaluating the Multiple Benefits of Bariatric Surgery After Roux-en-Y Gastric Bypass and Adjustable Gastric Band, OBESITY SURGERY, Vol: 24, Pages: 684-691, ISSN: 0960-8923
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- Citations: 17
Neff KJ, Prener C, Chuah LL, et al., 2014, A holistic assessment of bariatric surgical outcomes in a Northern Irish cohort., Ir Med J, Vol: 107, Pages: 24-26, ISSN: 0332-3102
The King's Obesity Staging system was developed to evaluate the effect of obesity treatments in multiple physical, psychological and functional domains. In this prospective cohort study, a Northern Irish cohort was scored using the King's Obesity Staging system before and 1 year after bariatric surgery. 71 individuals underwent surgery and 31 (44%) had type 2 diabetes. Bariatric surgery improved each health domain (p < 0.05). A subgroup with type 2 diabetes showed a significantly greater improvement in gonadal disease (polycystic ovarian syndrome and sub-fertility) (p = 0.02), and a trend towards greater improvement in cardiovascular disease (p = 0.07) compared with the non-diabetic subgroup. Half of those with pre-diabetes were normoglycaemic postoperatively (p < 0.05). The King's Obesity Staging system can be used to holistically evaluate the outcomes of bariatric surgery. Patients benefit from bariatric surgery in many ways, but those with diabetes may benefit more.
Hariri AA, Oliver NS, Johnston DG, et al., 2013, Adiposity Measurements by BMI, Skinfolds and Dual Energy X-Ray Absorptiometry in relation to Risk Markers for Cardiovascular Disease and Diabetes in Adult Males, Disease Markers, Vol: 35, Pages: 753-764, ISSN: 0278-0240
Background. Choice of adiposity measure may be important in the evaluation of relationships between adiposity and risk markers for cardiovascular disease and diabetes. Aim. We explored the strengths of risk marker associations with BMI, a simple measure of adiposity, and with measures provided by skinfold thicknesses and dual energy X-ray absorptiometry (DXA). Subjects and Methods. We evaluated in three subgroups of white males (–349), participating in a health screening program, the strengths of relationship between measures of total and regional adiposity and risk markers relating to blood pressure, lipids and lipoproteins, insulin sensitivity, and subclinical inflammation. Results. Independent of age, smoking, alcohol intake, and exercise, the strongest correlations with adiposity measures were seen with serum triglyceride concentrations and indices of insulin sensitivity, with strengths of association showing little difference between BMI and skinfold and DXA measures of total and percent body fat (–0.46, ). Significant but weaker associations with adiposity were seen for serum HDL cholesterol and only relatively inconsistent associations with adiposity for total and LDL cholesterol and indices of subclinical inflammation. Conclusions. BMI can account for variation in risk markers in white males as well as more sophisticated measures derived from skinfold thickness measurements or DXA scanning.
Ramachandran A, Snehalatha C, Ram J, et al., 2013, Efficacy of mobile phone messaging in prevention of type 2 diabetes by lifestyle change in men at high risk - A randomised clinical trial in India, Journal of Association of Physicians of India, Vol: 61, Pages: 951-952, ISSN: 0004-5772
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- Citations: 1
Ramachandran A, Snehalatha C, Ram J, et al., 2013, Effectiveness of mobile phone messaging in prevention of type 2 diabetes by lifestyle modification in men in India: a prospective, parallel-group, randomised controlled trial, The Lancet Diabetes & Endocrinology, Vol: 1, Pages: 191-198, ISSN: 2213-8587
Eastwood SV, Tillin T, Wright A, et al., 2013, Estimation of CT-Derived Abdominal Visceral and Subcutaneous Adipose Tissue Depots from Anthropometry in Europeans, South Asians and African Caribbeans, PLOS ONE, Vol: 8, ISSN: 1932-6203
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- Citations: 31
Forbes S, Godsland IF, Taylor-Robinson SD, et al., 2013, A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid, DIABETOLOGIA, Vol: 56, Pages: 2021-2033, ISSN: 0012-186X
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- Citations: 19
Tillin T, Sattar N, Godsland IF, et al., 2013, Ethnicity-specific obesity cut-points in the development of incident diabetes: a prospective study including three ethnic groups in the United Kingdom, 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S168-S168, ISSN: 0012-186X
Behary P, Godsland IF, Baynes KC, 2013, Indices of Beta Cell Function, but Not Fasting Glucagon, are Associated With Diabetes Control in Patients With Type 2 Diabetes on Stable GLP-1 Agonist Therapy, Publisher: AMER DIABETES ASSOC, Pages: A661-A661, ISSN: 0012-1797
Langley RE, Cafferty FH, Alhasso AA, et al., 2013, Cardiovascular outcomes in patients with locally advanced and metastatic prostate cancer treated with luteinising-hormone-releasing-hormone agonists or transdermal oestrogen: the randomised, phase 2 MRC PATCH trial (PR09), LANCET ONCOLOGY, Vol: 14, Pages: 306-316, ISSN: 1470-2045
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- Citations: 69
Neff KJ, Prenner C, Chuah LL, et al., 2013, Bariatric Surgery: A Holistic Assessment of Outcomes, 4th Annual Scientific Meeting of the British-Obesity-and-Metabolic-Surgery-Society (BOMSS), Publisher: WILEY-BLACKWELL, Pages: 4-4, ISSN: 0007-1323
Gray RG, Kousta E, McCarthy MI, et al., 2013, Ethnic variation in the activity of lipid desaturases and their relationships with cardiovascular risk factors in control women and an at-risk group with previous gestational diabetes mellitus: a cross-sectional study, LIPIDS IN HEALTH AND DISEASE, Vol: 12
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- Citations: 18
Tillin T, Hughes AD, Godsland IF, et al., 2013, Do risk factors measured 20 years previously predict and explain ethnic differences in HbA1c among non-diabetic British South Asians, African Caribbeans and Europeans?, Publisher: WILEY-BLACKWELL, Pages: 76-76, ISSN: 0742-3071
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- Citations: 1
Tillin T, Hughes AD, Godsland IF, et al., 2013, Insulin Resistance and Truncal Obesity as Important Determinants of the Greater Incidence of Diabetes in Indian Asians and African Caribbeans Compared With Europeans The Southall And Brent REvisited (SABRE) cohort, DIABETES CARE, Vol: 36, Pages: 383-393, ISSN: 0149-5992
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- Citations: 110
Manassiev N, Godsland IF, Proudler AJ, et al., 2013, Effects of tibolone or continuous combined oestradiol/norethisterone acetate on glucose and insulin metabolism, CLINICAL ENDOCRINOLOGY, Vol: 78, Pages: 297-302, ISSN: 0300-0664
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- Citations: 5
Yiannakouris N, Cooper JA, Shah S, et al., 2012, <i>IRS1</i> gene variants, dysglycaemic metabolic changes and type-2 diabetes risk, NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, Vol: 22, Pages: 1024-1030, ISSN: 0939-4753
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- Citations: 14
Mehta SR, Godsland IF, Thomas EL, et al., 2012, Intrahepatic Insulin Exposure, Intrahepatocellular Lipid and Regional Body Fat in Nonalcoholic Fatty Liver Disease, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 97, Pages: 2151-2159, ISSN: 0021-972X
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- Citations: 20
Mackness B, Marsillach J, Elkeles RS, et al., 2012, Paraoxonase-1 is not associated with coronary artery calcification in type 2 diabetes: Results from the PREDICT study, DISEASE MARKERS, Vol: 33, Pages: 101-112, ISSN: 0278-0240
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- Citations: 13
Godsland IF, Lecamwasam K, Johnston DG, 2011, A systematic evaluation of the insulin resistance syndrome as an independent risk factor for cardiovascular disease mortality and derivation of a clinical index, METABOLISM-CLINICAL AND EXPERIMENTAL, Vol: 60, Pages: 1442-1448, ISSN: 0026-0495
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- Citations: 19
Tillin T, Hughes AD, Whincup P, et al., 2011, Excess diabetes in ethnic minorities - incidence and predictors, 47th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S102-S103, ISSN: 0012-186X
Patel DC, Albrecht C, Pavitt D, et al., 2011, Type 2 Diabetes Is Associated with Reduced ATP-Binding Cassette Transporter A1 Gene Expression, Protein and Function, PLOS ONE, Vol: 6, ISSN: 1932-6203
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- Citations: 64
Pal A, Godsland I, Owen KR, et al., 2011, Investigating the role of the recently described Type 2 diabetes associated gene CDKN2A (p16) on pancreatic islet function using a human model of CDKN2A haploinsufficiency (vol 28, pg 53, 2011), DIABETIC MEDICINE, Vol: 28, Pages: 881-881, ISSN: 0742-3071
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- Citations: 1
Godsland IF, North BV, Johnston DG, 2011, Simple indices of inflammation as predictors of death from cancer or cardiovascular disease in a prospective cohort after two decades of follow-up, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 104, Pages: 387-394, ISSN: 1460-2725
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- Citations: 6
Yee MS, Pavitt DV, Dhanjil S, et al., 2010, The effects of rosiglitazone on atherosclerotic progression in patients with Type 2 diabetes at high cardiovascular risk, DIABETIC MEDICINE, Vol: 27, Pages: 1392-1400, ISSN: 0742-3071
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- Citations: 7
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