Publications
342 results found
Bravis V, Kaur A, Walkey H, et al., 2016, The effect of ethnicity on the clinical presentation of people with Type 1 diabetes and on humoral autoimmunity of the cohort within ADDRESS-2 (After Diagnosis Diabetes Research Support System 2), Publisher: Wiley, Pages: 25-25, ISSN: 0742-3071
Seechurn S, Reddy M, Jugnee N, et al., 2016, Does the addition of glucagon to a closed loop system impact on post exercise glycaemia?, ATTD 2016 9th International Conference on Advanced Technologies & Treatments for Diabetes, Publisher: Mary Ann Liebert, Pages: A60-A60, ISSN: 1520-9156
Seechurn S, Reddy M, Jugnee N, et al., 2016, Does the addition of glucagon to the closed loop insulin pump add any benefit?, ATTD 2016 9th International Conference on Advanced Technologies & Treatments for Diabetes, Publisher: Mary Ann Liebert, Pages: A61-A61, ISSN: 1520-9156
Pal A, Potjer TP, Thomsen SK, et al., 2016, Loss-of-function mutations in the cell-cycle control gene CDKN2A impact on glucose homeostasis in humans, Diabetes, Vol: 65, Pages: 527-533, ISSN: 0012-1797
At the CDKN2A/B locus, three independent signals for type 2 diabetes risk are located in a noncoding region near CDKN2A. The disease-associated alleles have been implicated in reduced β-cell function, but the underlying mechanism remains elusive. In mice, β-cell–specific loss of Cdkn2a causes hyperplasia, while overexpression leads to diabetes, highlighting CDKN2A as a candidate effector transcript. Rare CDKN2A loss-of-function mutations are a cause of familial melanoma and offer the opportunity to determine the impact of CDKN2A haploinsufficiency on glucose homeostasis in humans. To test the hypothesis that such individuals have improved β-cell function, we performed oral and intravenous glucose tolerance tests on mutation carriers and matched control subjects. Compared with control subjects, carriers displayed increased insulin secretion, impaired insulin sensitivity, and reduced hepatic insulin clearance. These results are consistent with a model whereby CDKN2A loss affects a range of different tissues, including pancreatic β-cells and liver. To test for direct effects of CDKN2A-loss on β-cell function, we performed knockdown in a human β-cell line, EndoC-bH1. This revealed increased insulin secretion independent of proliferation. Overall, we demonstrated that CDKN2A is an important regulator of glucose homeostasis in humans, thus supporting its candidacy as an effector transcript for type 2 diabetes–associated alleles in the region.
Godsland IF, Mehta S, Forbes S, et al., 2016, Is insulin resistance the principal cause of NAFLD?, CLINICAL DILEMMAS IN NON-ALCOHOLIC FATTY LIVER DISEASE, Editors: Williams, TaylorRobinson, Publisher: JOHN WILEY & SONS LTD, Pages: 15-28, ISBN: 978-1-118-91203-4
Anstee M, Argo CK, Brunt EM, et al., 2016, Clinical Dilemmas in Non-Alcoholic Fatty Liver Disease, Chichester, Publisher: Wiley, ISBN: 9781118912034
Reddy M, Godsland IF, Barnard KD, et al., 2015, Glycemic variability and its impact on quality of life in adults with type 1 diabetes, Journal of Diabetes Science and Technology, Vol: 10, Pages: 60-66, ISSN: 1932-2968
BACKGROUND: There is evidence suggesting that glycemic variability reduces quality of life (QoL) in people with type 2 diabetes, but this association has not been explored in type 1 diabetes. We aimed to assess whether glycemic variability has an impact on QoL in adults with established type 1 diabetes using multiple daily injections (MDI) of insulin or continuous subcutaneous insulin infusion (CSII). METHODS: Participants wore a blinded continuous glucose monitor for up to 5 days and completed the diabetes quality of life (DQOL) questionnaire. Glycemic variability measures were calculated using the EasyGV version 9.0 software. A correlation analysis was performed to assess whether there was a relationship between glycemic variability and measures of QoL. RESULTS: In all, 57 participants with type 1 diabetes (51% male, 65% on CSII, 35% on MDI, mean [SD] age 41 [13] years, duration of diabetes 21 [12] years, HbA1c 63 [12] mmol/mol [7.9% (1.1)], body mass index 25.2 [4.0] kg/m(2)) were included in the analysis. No significant associations between glycemic variability and DQOL total or subscale scores were demonstrated. The glycemic variability was significantly higher for MDI participants compared to CSII participants (P < .05 for all glycemic variability measures), but no significant difference in QoL between the 2 treatment modality groups was observed. CONCLUSIONS: Treatment with CSII is associated with lower glycemic variability compared to MDI. Despite this, and contrary to findings in type 2 diabetes, this study did not find an association between glycemic variability and QoL in adults with relatively well-controlled type 1 diabetes, irrespective of whether they are on MDI or CSII.
Priscilla S, Nanditha A, Simon M, et al., 2015, A pragmatic and scalable strategy using mobile technology to promote sustained lifestyle changes to prevent type 2 diabetes in India-Outcome of screening, DIABETES RESEARCH AND CLINICAL PRACTICE, Vol: 110, Pages: 335-340, ISSN: 0168-8227
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- Citations: 5
Ram J, Snehalatha C, Selvam S, et al., 2015, The oral disposition index is a strong predictor of incident diabetes in Asian Indian prediabetic men, ACTA DIABETOLOGICA, Vol: 52, Pages: 733-741, ISSN: 0940-5429
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- Citations: 14
Vinitha R, Ram J, Snehalatha C, et al., 2015, Adiponectin, leptin, interleukin-6 and HbA1c in the prediction of incident type 2 diabetes: A nested case-control study in Asian Indian men with impaired glucose tolerance, DIABETES RESEARCH AND CLINICAL PRACTICE, Vol: 109, Pages: 340-346, ISSN: 0168-8227
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- Citations: 12
Thomsen SK, Pal A, Potjer TP, et al., 2015, Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans, 75th Scientific Sessions of the American-Diabetes-Association, Publisher: AMER DIABETES ASSOC, Pages: A82-A83, ISSN: 0012-1797
Tillin T, Hughes AD, Wang Q, et al., 2015, Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study, DIABETOLOGIA, Vol: 58, Pages: 968-979, ISSN: 0012-186X
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- Citations: 160
Anagnostis P, Godsland IF, 2015, Cardiovascular disease risk in type 1 diabetes, Lancet Diabetes & Endocrinology, Vol: 3, Pages: 316-317, ISSN: 2213-8587
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- Citations: 1
Anagnostis P, Stevenson JC, Crook D, et al., 2015, Effects of menopause, gender and age on lipids and high-density lipoprotein cholesterol subfractions, MATURITAS, Vol: 81, Pages: 62-68, ISSN: 0378-5122
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- Citations: 106
Jagannathan R, Snehalatha C, Selvam S, et al., 2015, Retinol binding protein-4 predicts incident diabetes in Asian Indian men with prediabetes, BIOFACTORS, Vol: 41, Pages: 160-165, ISSN: 0951-6433
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- Citations: 24
Eastwood SV, Tillin T, Dehbi HM, et al., 2015, Ethnic Differences in Associations Between Fat Deposition and Incident Diabetes and Underlying Mechanisms: The SABRE Study, Obesity, Vol: 23, Pages: 699-706, ISSN: 1930-7381
ObjectiveTo examine ethnic differences in ectopic fat and associations with incident diabetes.MethodsIn a UK cohort study, 1338 Europeans, 838 South Asians, and 330 African Caribbeans living in London were aged 40-69 years at baseline. Baseline assessment included blood tests, anthropometry, and questionnaires. Anthropometry-based prediction equations estimated baseline visceral adipose tissue (VAT). Incident diabetes was ascertained from record review, self-report, or oral glucose tolerance testing.ResultsSouth Asians had more and African Caribbeans less estimated VAT than Europeans. Both ethnic minorities had larger truncal skinfolds than Europeans. In men, adjustment for risk factors (BMI, smoking, systolic blood pressure, and HDL-cholesterol) markedly attenuated the association between estimated VAT and diabetes in Europeans (standardized subhazard ratios [95% CI]: from 1.74 [1.49, 2.03] to 1.16 [0.77, 1.76]) and African Caribbeans (1.72 [1.26, 2.35] to 1.44 [0.69, 3.02]) but not South Asians (1.60 [1.38, 1.86] to 1.90 [1.37, 2.64]). In women, attenuation was observed only for South Asians (1.80 [1.01, 3.23] to 1.07 [0.49, 2.31]). Associations between truncal skinfolds and diabetes appeared less affected by multivariable adjustment in South Asians and African Caribbeans than Europeans (1.24 [0.97, 1.57] and 1.28 [0.89, 1.82] versus 1.02 [0.77, 1.36] in men; 1.91 [1.03, 3.56] and 1.42 [0.86, 2.34] versus 1.23 [0.74, 2.05] in women).ConclusionsDifferences in overall truncal fat, as well as VAT, may contribute to the excess of diabetes in South Asian and African Caribbean groups, particularly for women.
Tillin T, Hughes AD, Wang Q, et al., 2015, Amino acid profiles show a stronger relationship with incident diabetes in South Asian compared with European men, Publisher: WILEY-BLACKWELL, Pages: 29-29, ISSN: 0742-3071
Bravis V, Kaur A, Walkey H, et al., 2015, An incident and high risk Type 1 diabetes cohort, After Diagnosis Diabetes Research Support System (ADDRESS-2): initial clinical description of a multi-ethnic cohort in the UK, Publisher: WILEY-BLACKWELL, Pages: 85-85, ISSN: 0742-3071
Bravis V, Kaur A, Walkey H, et al., 2015, An incident and high risk Type 1 diabetes cohort, After Diagnosis Diabetes Research Support System (ADDRESS-2): description and comparison of clinical characteristics and presentation of patients with and without evidence of humoral autoimmunity, Publisher: WILEY-BLACKWELL, Pages: 86-86, ISSN: 0742-3071
Tillin T, Wang Q, Wurtz P, et al., 2015, Associations between low molecular weight metabolites and insulin resistance are stronger in South Asian compared with European women, Publisher: WILEY-BLACKWELL, Pages: 28-28, ISSN: 0742-3071
Bligh HFJ, Godsland IF, Frost G, et al., 2015, Plant-rich mixed meals based on Palaeolithic diet principles have a dramatic impact on incretin, peptide YY and satiety response, but show little effect on glucose and insulin homeostasis: an acute-effects randomised study, BRITISH JOURNAL OF NUTRITION, Vol: 113, Pages: 574-584, ISSN: 0007-1145
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- Citations: 29
El-Laboudi A, Godsland I, Johnston D, et al., 2015, EFFECT OF REAL-TIME CONTINUOUS GLUCOSE MONITORING ON MEASURES OF GLYCEMIC VARIABILITY AND QUALITY OF GLYCEMIC CONTROL IN TYPE 1 DIABETES, Publisher: MARY ANN LIEBERT, INC, Pages: A76-A76, ISSN: 1520-9156
Reddy M, Herrero P, El Sharkawy M, et al., 2015, METABOLIC CONTROL WITH THE BIO-INSPIRED ARTIFICIAL PANCREAS (BIAP) IN ADULTS WITH TYPE 1 DIABETES: A 24-HOUR RANDOMISED CONTROLLED CROSSOVER STUDY, Publisher: MARY ANN LIEBERT, INC, Pages: A20-A21, ISSN: 1520-9156
El-Laboudi A, Godsland I, Johnston D, et al., 2015, FACTORS PREDICTIVE OF EFFECT OF REAL-TIME CONTINUOUS GLUCOSE MONITORING ON MEASURES OF GLYCEMIC VARIABILITY AND QUALITY OF GLYCEMIC CONTROL IN TYPE 1 DIABETES, Publisher: MARY ANN LIEBERT, INC, Pages: A76-A77, ISSN: 1520-9156
Bravis V, Kaur A, Walkey H, et al., 2015, AN INCIDENT AND HIGH RISK TYPE 1 DIABETES COHORT - ADDRESS-2: CLINICAL PRESENTATION OF A MULTI-ETHNIC COHORT IN THE UK AND EFFECTS OF HUMORAL AUTOIMMUNITY, Publisher: MARY ANN LIEBERT, INC, Pages: A156-A156, ISSN: 1520-9156
Tillin T, Sattar N, Godsland IF, et al., 2015, Ethnicity-specific obesity cut-points in the development of Type 2 diabetes - a prospective study including three ethnic groups in the United Kingdom, DIABETIC MEDICINE, Vol: 32, Pages: 226-234, ISSN: 0742-3071
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- Citations: 60
Pérez-Pevida B, Sancho L, Guillén Valderrama F, et al., 2015, Optimization of metformin discontinuation in diabetic patients explored with 18F-FDG PET/CT, Pages: 1-607
Ram J, Selvam S, Snehalatha C, et al., 2014, Improvement in diet habits, independent of physical activity helps to reduce incident diabetes among prediabetic Asian Indian men, DIABETES RESEARCH AND CLINICAL PRACTICE, Vol: 106, Pages: 491-495, ISSN: 0168-8227
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- Citations: 27
Anagnostis P, Majeed A, Johnston DG, et al., 2014, Cardiovascular risk in women with type 2 diabetes mellitus and prediabetes: is it indeed higher than men?, EUROPEAN JOURNAL OF ENDOCRINOLOGY, Vol: 171, Pages: R245-R255, ISSN: 0804-4643
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- Citations: 18
Ram J, Snehalatha C, Nanditha A, et al., 2014, Hypertriglyceridaemic waist phenotype as a simple predictive marker of incident diabetes in Asian-Indian men with prediabetes, DIABETIC MEDICINE, Vol: 31, Pages: 1542-1549, ISSN: 0742-3071
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- Citations: 9
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