Imperial College London
Alternate

DrIanGodsland

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Wynn Reader in Human Metabolism
 
 
 
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Contact

 

+44 (0)20 3312 6573i.godsland

 
 
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Assistant

 

Mrs Heather Bones +44 (0)20 7594 2429

 
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Location

 

Room G1Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Srivanichakorn:2019:10.1111/jdi.12967,
author = {Srivanichakorn, W and Godsland, IF and Washirasaksiri, C and Phisalprapa, P and Charatcharoenwitthaya, P and Pramyothin, P and Sitasuwan, T and Preechasuk, L and Elkeles, R and Alberti, KGMM and Johnston, DG and Oliver, NS},
doi = {10.1111/jdi.12967},
journal = {Journal of Diabetes Investigation},
pages = {771--779},
title = {Cardiometabolic risk factors in Thai individuals with prediabetes treated in a high-risk, prevention clinic - unexpected relationship between HDL cholesterol and glycaemia in men},
url = {http://dx.doi.org/10.1111/jdi.12967},
volume = {10},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Relationships between cardiometabolic risk and glycaemia have been rarely studied in people under clinical evaluation and treatment for cardiometabolic risk and with prediabetes. We investigated relationships between glycaemia and cardiometabolic risk factors in clinic participants with prediabetes. METHODS: This was a cross-sectional analysis of data collected at a centre in Thailand. Clinic attendees were at high-risk of diabetes or cardiovascular disease, with HbA1c 39-<48 mmol/mol or fasting plasma glucose (FPG) 5.6-<7.0 mmol/L. The relationships between glycaemia and cardiometabolic risk factors were explored. RESULTS: Of 357 participants, two or more insulin resistance-related metabolic disturbances were present in 84%; 61% took a statin and 75% an antihypertensive agent. Independently of age, gender, adiposity, medication use, possible NAFLD and gender-glycaemia interaction, neither FPG nor HbA1c were associated with variation in any other cardiometabolic risk factors. HDL cholesterol decreased with HbA1c in women (femaleHbA1c interaction, p=0.03) but, unexpectedly, increased with FPG in men (maleFPG interaction, p=0.02). CONCLUSION: Overall, in Thai people treated for high-cardiometabolic risk and with prediabetes defined by FPG and/or HbA1c, neither FPG nor HbA1c were associated with other cardiometabolic risk factors. However, according to gender, HDL cholesterol showed the expected relationship with glycaemia in women but the reverse in men.
AU  - Srivanichakorn,W
AU  - Godsland,IF
AU  - Washirasaksiri,C
AU  - Phisalprapa,P
AU  - Charatcharoenwitthaya,P
AU  - Pramyothin,P
AU  - Sitasuwan,T
AU  - Preechasuk,L
AU  - Elkeles,R
AU  - Alberti,KGMM
AU  - Johnston,DG
AU  - Oliver,NS
DO  - 10.1111/jdi.12967
EP  - 779
PY  - 2019///
SN  - 2040-1124
SP  - 771
TI  - Cardiometabolic risk factors in Thai individuals with prediabetes treated in a high-risk, prevention clinic - unexpected relationship between HDL cholesterol and glycaemia in men
T2  - Journal of Diabetes Investigation
UR  - http://dx.doi.org/10.1111/jdi.12967
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30387292
UR  - http://hdl.handle.net/10044/1/64465
VL  - 10
ER  -
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