Imperial College London
Alternate

DrIanGodsland

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Wynn Reader in Human Metabolism
 
 
 
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Contact

 

+44 (0)20 3312 6573i.godsland

 
 
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Assistant

 

Mrs Heather Bones +44 (0)20 7594 2429

 
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Location

 

Room G1Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Humphreys:2019:10.1016/j.diabres.2019.107789,
author = {Humphreys, A and Bravis, V and Kaur, A and Walkey, HC and Godsland, IF and Misra, S and Johnston, DG and Oliver, NS},
doi = {10.1016/j.diabres.2019.107789},
journal = {Diabetes Research and Clinical Practice},
title = {Individual and diabetes presentation characteristics associated with partial remission status in children and adults evaluated up to 12months following diagnosis of type 1 diabetes: An ADDRESS-2 (After Diagnosis Diabetes Research Support System-2) study analysis},
url = {http://dx.doi.org/10.1016/j.diabres.2019.107789},
volume = {155},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AIMS: People with recently-diagnosed type 1 diabetes mellitus (T1D) may undergo a transient period of glycaemic control with less exogenous insulin. Identification of predictors of this 'remission' could inform a better understanding of glycaemic control. METHODS: Participants in the ADDRESS-2 study were included who had 1 or 2 assessments of remission status (coincident insulin dose and HbA1c measurement, with remission defined by ≤0.4 units insulin/kg-body-weight/day with HbA1c<53mmol/mol). Demographic and clinical presentation characteristics were compared according to remission status and predictors of remission were explored by logistic regression analysis. RESULTS: 1470 first and 469second assessments of remission status were recorded within 12months of diagnosis of T1D. Step increases in the probability of remission were identified at age-at-diagnosis 20years and 3months after diagnosis (both p<0.001). Among those aged<20years, remission was associated with male gender (p=0.02), no ketoacidosis (p=0.02) and fewer than 2 symptoms at presentation (p=0.004). None of these characteristics predicted remission in those aged≥20years. In the subgroup with two assessments, transition to remission was independently associated with first remission assessment in months 1-2 post-diagnosis (p=0.01), with age-at-diagnosis≥20years (p=0.01) and, in those aged<20years, with an early HbA1c of <57mmol/mol. Adiposity, ethnicity, autoantibody status and other autoimmune disease were unrelated to remission. CONCLUSIONS: For those diagnosed before 20years of age, males, ketoacidosis-free, with fewer symptoms and low early HbA1c were more likely to experience remission, but remission was most likely in anyone aged≥20 at diagnosis.
AU  - Humphreys,A
AU  - Bravis,V
AU  - Kaur,A
AU  - Walkey,HC
AU  - Godsland,IF
AU  - Misra,S
AU  - Johnston,DG
AU  - Oliver,NS
DO  - 10.1016/j.diabres.2019.107789
PY  - 2019///
SN  - 0168-8227
TI  - Individual and diabetes presentation characteristics associated with partial remission status in children and adults evaluated up to 12months following diagnosis of type 1 diabetes: An ADDRESS-2 (After Diagnosis Diabetes Research Support System-2) study analysis
T2  - Diabetes Research and Clinical Practice
UR  - http://dx.doi.org/10.1016/j.diabres.2019.107789
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31326456
UR  - http://hdl.handle.net/10044/1/72559
VL  - 155
ER  -
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