Publications

BibTex format

@article{Pan:2021:ajcn/nqab152,
author = {Pan, X-F and Yang, JJ and Shu, X-O and Moore, SC and Palmer, ND and Guasch-Ferré, M and Herrington, DM and Harada, S and Eliassen, H and Wang, TJ and Gerszten, RE and Albanes, D and Tzoulaki, I and Karaman, I and Elliott, P and Zhu, H and Wagenknecht, LE and Zheng, W and Cai, H and Cai, Q and Matthews, CE and Menni, C and Meyer, KA and Lipworth, LP and Ose, J and Fornage, M and Ulrich, CM and Yu, D},
doi = {ajcn/nqab152},
journal = {American Journal of Clinical Nutrition},
pages = {893--906},
title = {Associations of circulating choline and its related metabolites with cardiometabolic biomarkers: an international pooled analysis},
url = {http://dx.doi.org/10.1093/ajcn/nqab152},
volume = {114},
year = {2021}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Choline is an essential nutrient; however, the associations of choline and its related metabolites with cardiometabolic risk remain unclear. OBJECTIVE: We examined the associations of circulating choline, betaine, carnitine, and dimethylglycine (DMG) with cardiometabolic biomarkers and their potential dietary and nondietary determinants. METHODS: The cross-sectional analyses included 32,853 participants from 17 studies, who were free of cancer, cardiovascular diseases, chronic kidney diseases, and inflammatory bowel disease. In each study, metabolites and biomarkers were log-transformed and standardized by means and SDs, and linear regression coefficients (β) and 95% CIs were estimated with adjustments for potential confounders. Study-specific results were combined by random-effects meta-analyses. A false discovery rate <0.05 was considered significant. RESULTS: We observed moderate positive associations of circulating choline, carnitine, and DMG with creatinine [β (95% CI): 0.136 (0.084, 0.188), 0.106 (0.045, 0.168), and 0.128 (0.087, 0.169), respectively, for each SD increase in biomarkers on the log scale], carnitine with triglycerides (β = 0.076; 95% CI: 0.042, 0.109), homocysteine (β = 0.064; 95% CI: 0.033, 0.095), and LDL cholesterol (β = 0.055; 95% CI: 0.013, 0.096), DMG with homocysteine (β = 0.068; 95% CI: 0.023, 0.114), insulin (β = 0.068; 95% CI: 0.043, 0.093), and IL-6 (β = 0.060; 95% CI: 0.027, 0.094), but moderate inverse associations of betaine with triglycerides (β = -0.146; 95% CI: -0.188, -0.104), insulin (β = -0.106; 95% CI: -0.130, -0.082), homocysteine (β = -0.097; 95% CI: -0.149, -0.045), and total cholesterol (β = -0.074; 95% CI: -0.102, -0.047). In the whole pooled population, no dietary factor was associated with circulating choline; red meat intake was associated with circulating carnitine [β = 0.092 (0.042, 0.142) for a 1 serving/d increase], whereas plant prot
AU  - Pan,X-F
AU  - Yang,JJ
AU  - Shu,X-O
AU  - Moore,SC
AU  - Palmer,ND
AU  - Guasch-Ferré,M
AU  - Herrington,DM
AU  - Harada,S
AU  - Eliassen,H
AU  - Wang,TJ
AU  - Gerszten,RE
AU  - Albanes,D
AU  - Tzoulaki,I
AU  - Karaman,I
AU  - Elliott,P
AU  - Zhu,H
AU  - Wagenknecht,LE
AU  - Zheng,W
AU  - Cai,H
AU  - Cai,Q
AU  - Matthews,CE
AU  - Menni,C
AU  - Meyer,KA
AU  - Lipworth,LP
AU  - Ose,J
AU  - Fornage,M
AU  - Ulrich,CM
AU  - Yu,D
DO  - ajcn/nqab152
EP  - 906
PY  - 2021///
SN  - 0002-9165
SP  - 893
TI  - Associations of circulating choline and its related metabolites with cardiometabolic biomarkers: an international pooled analysis
T2  - American Journal of Clinical Nutrition
UR  - http://dx.doi.org/10.1093/ajcn/nqab152
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34020444
UR  - http://hdl.handle.net/10044/1/89797
VL  - 114
ER  -

Download

DrIbrahimKaraman

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)