Imperial College London


Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Reader in Diabetic Medicine



+44 (0)20 7594




323ICTEM buildingHammersmith Campus





Isabelle Leclerc is Senior Clinical Lecturer in Diabetes & Endocrinology, Section of Cell Biology, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Faculty of Medicine, Imperial College London and Honorary Consultant in Diabetes & Endocrinology, St-Mary’s Hospital, Imperial College Healthcare NHS Trust, London, UK.

She trained as a clinician at the University of Montreal in Internal Medicine and Endocrinology and Metabolism and as a scientist at the University Rene Descartes in Paris where she obtained a PhD in Cellular and Molecular Biology.

Her research focuses on pancreatic islet beta-cell dysfunction in type 2 diabetes. Her principal interest is beta-cell compensation during the early stages of insulin resistance and subsequent alterations in gene expression and signalling that eventually lead to beta-cell failure and overt diabetes.



Mousavy Gharavy SN, Owen BM, Millership SJ, et al., 2021, Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis, Diabetologia, Vol:64, ISSN:0012-186X, Pages:850-864

Nguyen-Tu M-S, Martinez-Sanchez A, Leclerc I, et al., 2020, Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice, Diabetologia, Vol:64, ISSN:0012-186X, Pages:129-141

Carrat GR, Haythorne E, Tomas A, et al., 2020, The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis, Molecular Metabolism, Vol:40, ISSN:2212-8778


Akalestou E, Lopez-Noriega L, Leclerc I, et al., 2020, Metabolic surgery inhibits sodium glucose co-transporter 2 (SGLT2) expression in the kidney of lean mice, WILEY, Pages:43-43, ISSN:0742-3071

Ali UT, Suba K, Bitsi S, et al., 2020, Improving islet transplantation success by increasing expression of the epidermal growth factor receptor (EGFR), WILEY, Pages:36-36, ISSN:0742-3071

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