Summary
Isabelle Leclerc is Senior Clinical Lecturer in Diabetes & Endocrinology, Section of Cell Biology, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Faculty of Medicine, Imperial College London and Honorary Consultant in Diabetes & Endocrinology, St-Mary’s Hospital, Imperial College Healthcare NHS Trust, London, UK.
She trained as a clinician at the University of Montreal in Internal Medicine and Endocrinology and Metabolism and as a scientist at the University Rene Descartes in Paris where she obtained a PhD in Cellular and Molecular Biology.
Her research focuses on pancreatic islet beta-cell dysfunction in type 2 diabetes. Her principal interest is beta-cell compensation during the early stages of insulin resistance and subsequent alterations in gene expression and signalling that eventually lead to beta-cell failure and overt diabetes.
Publications
Journals
Nguyen-Tu M-S, da Silva Xavier G, Leclerc I, et al., 2018, Transcription factor-7-like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTOR signaling, β cell growth, and insulin secretion, Journal of Biological Chemistry, ISSN:0021-9258
Martinez-Sanchez A, Nguyen-Tu M-S, Cebola I, et al., 2018, MiR-184 expression is regulated by AMPK in pancreatic islets., Faseb Journal, Vol:32, ISSN:0892-6638, Pages:2587-2600
Conference
Gharavy SNM, Hu M, Gadue P, et al., 2019, Roles for the Type 2 diabetes-associated genes C2CD4A and C2CD4B in the control of glucose homeostasis and insulin secretion, WILEY, Pages:43-43, ISSN:0742-3071
Salem V, Suba K, Martin Alonso A, et al., Real-Time In Vivo Imaging of Whole Islet Ca2+ Dynamics Reveals Glucose-Induced Changes in Beta-Cell Connectivity in Mouse and Human Islets, American Diabetes Association, 78th Scientific Sessions, American Diabetes Association, ISSN:0012-1797
Carrat GR, Haythorne E, Chabosseau P, et al., 2018, The Type 2 diabetes genome-wide association study (GWAS) gene STARD10 controls beta cell granule morphogenesis and proinsulin release, Diabetes UK, WILEY, Pages:46-46, ISSN:0742-3071