Isabelle Leclerc is Senior Clinical Lecturer in Diabetes & Endocrinology, Section of Cell Biology, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Faculty of Medicine, Imperial College London and Honorary Consultant in Diabetes & Endocrinology, St-Mary’s Hospital, Imperial College Healthcare NHS Trust, London, UK.
She trained as a clinician at the University of Montreal in Internal Medicine and Endocrinology and Metabolism and as a scientist at the University Rene Descartes in Paris where she obtained a PhD in Cellular and Molecular Biology.
Her research focuses on pancreatic islet beta-cell dysfunction in type 2 diabetes. Her principal interest is beta-cell compensation during the early stages of insulin resistance and subsequent alterations in gene expression and signalling that eventually lead to beta-cell failure and overt diabetes.
et al., 2020, The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis., Mol Metab
et al., 2020, The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice, Diabetologia, ISSN:0012-186X
et al., 2020, Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of beta-cell-dependent contrast enhancement in the pancreas, Dalton Transactions, Vol:49, ISSN:1477-9226, Pages:4732-4740
et al., 2019, Leader β cells coordinate Ca2+ dynamics across pancreatic islets in vivo, Nature Metabolism, Vol:1, ISSN:2522-5812, Pages:615-629
et al., 2019, The long non-coding RNA PAX6-AS1 controls human beta cell identity, 55th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), SPRINGER, Pages:S205-S206, ISSN:0012-186X