Isabelle Leclerc is Senior Clinical Lecturer in Diabetes & Endocrinology, Section of Cell Biology, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Faculty of Medicine, Imperial College London and Honorary Consultant in Diabetes & Endocrinology, St-Mary’s Hospital, Imperial College Healthcare NHS Trust, London, UK.
She trained as a clinician at the University of Montreal in Internal Medicine and Endocrinology and Metabolism and as a scientist at the University Rene Descartes in Paris where she obtained a PhD in Cellular and Molecular Biology.
Her research focuses on pancreatic islet beta-cell dysfunction in type 2 diabetes. Her principal interest is beta-cell compensation during the early stages of insulin resistance and subsequent alterations in gene expression and signalling that eventually lead to beta-cell failure and overt diabetes.
et al., 2018, Transcription factor-7-like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTOR signaling,beta cell growth, and insulin secretion (vol 293, pg 14178, 2018), Journal of Biological Chemistry, Vol:293, ISSN:0021-9258, Pages:18420-18420
et al., 2018, Transcription factor-7-like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTOR signaling, cell growth, and insulin secretion, Journal of Biological Chemistry, Vol:293, ISSN:0021-9258, Pages:14178-14189
et al., 2018, MiR-184 expression is regulated by AMPK in pancreatic islets, Faseb Journal, Vol:32, ISSN:0892-6638, Pages:2587-2600
et al., 2018, The Type 2 diabetes genome-wide association study (GWAS) gene STARD10 controls beta cell granule morphogenesis and proinsulin release, WILEY, Pages:46-46, ISSN:0742-3071
et al., 2018, Adenosine Monophosphate (AMP)-activated protein kinase (AMPK) regulates the expression of miR-184 and other miRNAs important for beta cell function, WILEY, Pages:48-48, ISSN:0742-3071