Imperial College London


Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Visiting Professor



+44 (0)20 7594




323ICTEM buildingHammersmith Campus





Isabelle Leclerc is Senior Clinical Lecturer in Diabetes & Endocrinology, Section of Cell Biology, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Faculty of Medicine, Imperial College London and Honorary Consultant in Diabetes & Endocrinology, St-Mary’s Hospital, Imperial College Healthcare NHS Trust, London, UK.

She trained as a clinician at the University of Montreal in Internal Medicine and Endocrinology and Metabolism and as a scientist at the University Rene Descartes in Paris where she obtained a PhD in Cellular and Molecular Biology.

Her research focuses on pancreatic islet beta-cell dysfunction in type 2 diabetes. Her principal interest is beta-cell compensation during the early stages of insulin resistance and subsequent alterations in gene expression and signalling that eventually lead to beta-cell failure and overt diabetes.



Firth G, Georgiadou E, Griffiths A, et al., 2023, Impact of an SLC30A8 loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice, Frontiers in Endocrinology, Vol:14, ISSN:1664-2392, Pages:1-12

Slieker R, Donnellly L, Akalestou E, et al., 2023, Identification of biomarkers for glycaemic deterioration in type 2 diabetes, Nature Communications, Vol:14, ISSN:2041-1723, Pages:1-18

Chabosseau P, Yong F, Delgadillo-Silva LF, et al., 2023, Molecular phenotyping of single pancreatic islet leader beta cells by "Flash-Seq", Life Sciences, Vol:316, ISSN:0024-3205

Parks SZ, Rutter GA, Leclerc I, 2022, Effects of whole-body sorcin knockout on body weight and hypothalamic ER-stress in C57BL/6 male mice fed a westernized diet

Akalestou E, Lopez-Noriega L, Christakis I, et al., 2022, Vertical Sleeve Gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice, Frontiers in Endocrinology, Vol:13, ISSN:1664-2392, Pages:1-16

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