Imperial College London
Alternate

DrIsabelleLeclerc

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3354i.leclerc

 
 
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Location

 

323ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Akalestou:2022:10.2337/db21-0768,
author = {Akalestou, E and Lopez-Noriega, L and Tough, IR and Hu, M and Leclerc, I and Cox, HM and Rutter, GA},
doi = {10.2337/db21-0768},
journal = {Diabetes},
title = {Vertical sleeve gastrectomy lowers SGLT2/Slc5a2 expression in the mouse kidney},
url = {http://dx.doi.org/10.2337/db21-0768},
volume = {71},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Bariatric surgery improves glucose homeostasis but the underlying mechanisms are not fully elucidated. Here, we show that the expression of sodium glucose cotransporter-2 (SGLT2/Slc5a2) is reduced in the kidney of lean and obese mice following vertical sleeve gastrectomy (VSG). Indicating an important contribution of altered cotransporter expression to the impact of surgery, inactivation of the SGLT2/Slc5a2 gene by CRISPR/Cas9 attenuated the effects of VSG, with glucose excursions following intraperitoneal injection lowered by ∼30% in wild-type mice but by ∼20% in SGLT2 null animals. The effects of the SGLT2 inhibitor dapaglifozin were similarly blunted by surgery. Unexpectedly, effects of dapaglifozin were still observed in SGLT2 null mice, consistent with the existence of metabolically beneficial off-target effects of SGLT2 inhibitors. Thus, we describe a new mechanism involved in mediating the glucose lowering effects of bariatric surgery.
AU  - Akalestou,E
AU  - Lopez-Noriega,L
AU  - Tough,IR
AU  - Hu,M
AU  - Leclerc,I
AU  - Cox,HM
AU  - Rutter,GA
DO  - 10.2337/db21-0768
PY  - 2022///
SN  - 0012-1797
TI  - Vertical sleeve gastrectomy lowers SGLT2/Slc5a2 expression in the mouse kidney
T2  - Diabetes
UR  - http://dx.doi.org/10.2337/db21-0768
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35594379
UR  - https://diabetesjournals.org/diabetes/article-abstract/71/8/1623/146985/Vertical-Sleeve-Gastrectomy-Lowers-SGLT2-Slc5a2?redirectedFrom=fulltext
UR  - http://hdl.handle.net/10044/1/97558
VL  - 71
ER  -
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