Imperial College London

DrIsabelleLeclerc

Faculty of MedicineDepartment of Medicine

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3354i.leclerc

 
 
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Location

 

323ICTEM buildingHammersmith Campus

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Summary

 

Collaborators

Dhan V. Kalvakolanu, Ph.D., University of Maryland School of Medicine, ATF6 FRET sensor, 2017

Alejandra Tomas, Imperial College London, Electron microscopy of ER-mitochondria junctions pancreatic beta cells, 2016

Dr Catherine Postic, INSERM, ChREBP in the liver, 2015

Prof Fiona Gribble, University of Cambridge Metabolic Research Laboratories, Incretin biology, 2015

Richard O'Brien, Vanderbilt University, G6PC2 and sorcin, 2015

Prof Phillipp E. Scherer, PhD, The University of Texas Southwestern Medical Center, Adipose tissue specific rtTA transgenic mouse, 2015

Prof Hector Valdivia, University of Michigan, Sorcin, 2014

Guest Lectures

Sorcin links ER Ca2+ Stores to Beta Cell Lipotoxicity. Novel Islet Signaling Pathways Symposium., 77th Scientific Sessions, American Diabetes Association, San Diego, California, USA, 2017

Research Staff

Diraison,F

Khera,T

Marmugi,AP

Noordeen,DN

Scott,F

Scott,F

da Silva Xavier,G

Research Student Supervision

Ayathamattam,J, Generation and characterisation of Sri-/- MEF cell lines with regards to ER stress and ATF6 activity

Bellomo,E, Divalent metal ions in pancreatic beta-cell function: role in the pathogenesis of type 2 diabetes

Carmichael,L, The role of calcium sensor Sorcin in ER stress-induced apoptosis in pancreatic beta cells

Carmichael,L, The role of calcium sensor Sorcin in ER-stress-induced apoptosis in pancreatic beta cells

Gao,T, Is sorcin an ER stress marker

Hall,D, Exploration of sorcin’s therapeutic potential against lipoglucotoxicity in pancreatic β-cells

Jimenez Awuapara,N, Generation and characterisation of Sorcin knockout human embryonic kidney 293 cell line by CRISPR/Cas9: effects on endoplasmic reticulum stress and ATF6 activation

Kwieder,B, Investigating the roles of Pin1 in pancreatic islet beta cells

Mannan,N, Regulation of the G6PC2 promoter by glucose and sorcin in pancreatic beta cells

Parks,S, Investigating the role of sorcin in the development of ER stress-induced obesity and Type 2 diabetes

Patel,P, Investigating the interaction of ChREBP and sorcin in mammalian cell lines

Sun,G, Roles of AMP-activated protein kinase (AMPK) and liver kinase B1 (LKB1) in controlling pancreatic islet hormone secretion

Thepaut,C, The role of sorcin in pancreatic beta-cell viability and apoptosis

Wai,FS, Exploration of sorcin therapeutic potential against glucolipotoxicity in pancreatic beta cells