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@article{Lenglart:2023:10.1183/13993003.01172-2022,
author = {Lenglart, L and Ouldali, N and Honeyford, K and Bognar, Z and Bressan, S and Buonsenso, D and Da, Dalt L and De, T and Farrugia, R and Maconochie, IK and Moll, HA and Oostenbrink, R and Parri, N and Roland, D and Rose, K and Akyüz, Özkan E and Angoulvant, F and Aupiais, C and Barber, C and Barrett, M and Basmaci, R and Castanhinha, S and Chiaretti, A and Durnin, S and Fitzpatrick, P and Fodor, L and Gomez, B and Greber-Platzer, S and Guedj, R and Hey, F and Jankauskaite, L and Kohlfuerst, D and Mascarenhas, I and Musolino, AM and Puuka, Z and Reis, S and Rybak, A and Salamon, P and Schaffert, M and Shahar-Nissan, K and Supino, MC and Teksam, O and Turan, C and Velasco, R and Nijman, RG and Titomanlio, L and EPISODES, Study Group},
doi = {10.1183/13993003.01172-2022},
journal = {European Respiratory Journal},
pages = {1--12},
title = {Respective roles of non-pharmaceutical interventions in bronchiolitis outbreaks: an interrupted time-series analysis based on a multinational surveillance system},
url = {http://dx.doi.org/10.1183/13993003.01172-2022},
volume = {61},
year = {2023}
}

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TY  - JOUR
AB  - BACKGROUND: Bronchiolitis is a major source of morbimortality among young children worldwide. Non-pharmaceutical interventions (NPIs) implemented to reduce the spread of severe acute respiratory syndrome coronavirus 2 may have had an important impact on bronchiolitis outbreaks, as well as major societal consequences. Discriminating between their respective impacts would help define optimal public health strategies against bronchiolitis. We aimed to assess the respective impact of each NPI on bronchiolitis outbreaks in 14 European countries. METHODS: We conducted a quasi-experimental interrupted time-series analysis based on a multicentre international study. All children diagnosed with bronchiolitis presenting to the paediatric emergency department of one of 27 centres from January 2018 to March 2021 were included. We assessed the association between each NPI and change in the bronchiolitis trend over time by seasonally adjusted multivariable quasi-Poisson regression modelling. RESULTS: In total, 42 916 children were included. We observed an overall cumulative 78% (95% CI -100- -54%; p<0.0001) reduction in bronchiolitis cases following NPI implementation. The decrease varied between countries from -97% (95% CI -100- -47%; p=0.0005) to -36% (95% CI -79-7%; p=0.105). Full lockdown (incidence rate ratio (IRR) 0.21 (95% CI 0.14-0.30); p<0.001), secondary school closure (IRR 0.33 (95% CI 0.20-0.52); p<0.0001), wearing a mask indoors (IRR 0.49 (95% CI 0.25-0.94); p=0.034) and teleworking (IRR 0.55 (95% CI 0.31-0.97); p=0.038) were independently associated with reducing bronchiolitis. CONCLUSIONS: Several NPIs were associated with a reduction of bronchiolitis outbreaks, including full lockdown, school closure, teleworking and facial masking. Some of these public health interventions may be considered to further reduce the global burden of bronchiolitis.
AU  - Lenglart,L
AU  - Ouldali,N
AU  - Honeyford,K
AU  - Bognar,Z
AU  - Bressan,S
AU  - Buonsenso,D
AU  - Da,Dalt L
AU  - De,T
AU  - Farrugia,R
AU  - Maconochie,IK
AU  - Moll,HA
AU  - Oostenbrink,R
AU  - Parri,N
AU  - Roland,D
AU  - Rose,K
AU  - Akyüz,Özkan E
AU  - Angoulvant,F
AU  - Aupiais,C
AU  - Barber,C
AU  - Barrett,M
AU  - Basmaci,R
AU  - Castanhinha,S
AU  - Chiaretti,A
AU  - Durnin,S
AU  - Fitzpatrick,P
AU  - Fodor,L
AU  - Gomez,B
AU  - Greber-Platzer,S
AU  - Guedj,R
AU  - Hey,F
AU  - Jankauskaite,L
AU  - Kohlfuerst,D
AU  - Mascarenhas,I
AU  - Musolino,AM
AU  - Puuka,Z
AU  - Reis,S
AU  - Rybak,A
AU  - Salamon,P
AU  - Schaffert,M
AU  - Shahar-Nissan,K
AU  - Supino,MC
AU  - Teksam,O
AU  - Turan,C
AU  - Velasco,R
AU  - Nijman,RG
AU  - Titomanlio,L
AU  - EPISODES,Study Group
DO  - 10.1183/13993003.01172-2022
EP  - 12
PY  - 2023///
SN  - 0903-1936
SP  - 1
TI  - Respective roles of non-pharmaceutical interventions in bronchiolitis outbreaks: an interrupted time-series analysis based on a multinational surveillance system
T2  - European Respiratory Journal
UR  - http://dx.doi.org/10.1183/13993003.01172-2022
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36356971
UR  - https://erj.ersjournals.com/content/61/2/2201172
VL  - 61
ER  -

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