Iain McNeish is Professor of Oncology and Head of the Division of Cancer within the Department of Surgery and Cancer. He is also the Director of the Ovarian Cancer Action Research Centre and Cancer theme lead in the Imperial NIHR Biomedical Research Centre (BRC). Externally, he is Chair of the NCRI Gynaecological CSG.
His research focusses on ovarian cancer, specifically developing improved therapies through improved understanding of disease biology. With James Brenton in Cambridge, he co-leads the BriTROC translational research collaborative and holds a programme grant from Cancer Research UK investigating copy number alterations in ovarian high grade serous carcinoma (HGSC) as a possible prognostic and predictive biomarker. His group has also recently developed novel transplantable murine models of HGSC using CRISPR/Cas9 gene editing technology to allow investigation of novel therapies in an immunocompetent model. These transplantable cells are freely available to researchers.
et al., 2016, CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma, Cancer Research, Vol:76, ISSN:1538-7445, Pages:6118-6129