Imperial College London
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ProfessorIainMcNeish

Faculty of Medicine, Department of Surgery & Cancer

Chair in Oncology
 
 
 
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Contact

 

+44 (0)20 7594 2185i.mcneish Website

 
 
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Assistant

 

Ms Sophie Lions +44 (0)20 7594 2792

 
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Location

 

G036Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Macintyre:2018:10.1038/s41588-018-0179-8,
author = {Macintyre, G and Goranova, TE and De, Silva D and Ennis, D and Piskorz, AM and Eldridge, M and Sie, D and Lewsley, L-A and Hanif, A and Wilson, C and Dowson, S and Glasspool, RM and Lockley, M and Brockbank, E and Montes, A and Walther, A and Sundar, SS and Edmondson, R and Hall, GD and Clamp, A and Gourley, C and Hall, M and Fotopoulou, C and Gabra, H and Paul, J and Supernat, A and Millan, D and Hoyle, A and Bryson, G and Nourse, C and Mincarelli, L and Navarro, Sanchez L and Ylstra, B and Jimenez-Linan, M and Moore, L and Hofmann, O and Markowetz, F and McNeish, IA and Brenton, JD},
doi = {10.1038/s41588-018-0179-8},
journal = {Nature Genetics},
pages = {1262--1270},
title = {Copy-number signatures and mutational processes in ovarian carcinoma},
url = {http://dx.doi.org/10.1038/s41588-018-0179-8},
volume = {50},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The genomic complexity of profound copy-number aberration has prevented effective molecular stratification of ovarian cancers. To decode this complexity, we derived copy-number signatures from shallow whole genome sequencing of 117 high-grade serous ovarian cancer (HGSOC) cases, which were validated on 527 independent cases. We show that HGSOC comprises a continuum of genomes shaped by multiple mutational processes that result in known patterns of genomic aberration. Copy-number signature exposures at diagnosis predict both overall survival and the probability of platinum-resistant relapse. Measuring signature exposures provides a rational framework to choose combination treatments that target multiple mutational processes.
AU  - Macintyre,G
AU  - Goranova,TE
AU  - De,Silva D
AU  - Ennis,D
AU  - Piskorz,AM
AU  - Eldridge,M
AU  - Sie,D
AU  - Lewsley,L-A
AU  - Hanif,A
AU  - Wilson,C
AU  - Dowson,S
AU  - Glasspool,RM
AU  - Lockley,M
AU  - Brockbank,E
AU  - Montes,A
AU  - Walther,A
AU  - Sundar,SS
AU  - Edmondson,R
AU  - Hall,GD
AU  - Clamp,A
AU  - Gourley,C
AU  - Hall,M
AU  - Fotopoulou,C
AU  - Gabra,H
AU  - Paul,J
AU  - Supernat,A
AU  - Millan,D
AU  - Hoyle,A
AU  - Bryson,G
AU  - Nourse,C
AU  - Mincarelli,L
AU  - Navarro,Sanchez L
AU  - Ylstra,B
AU  - Jimenez-Linan,M
AU  - Moore,L
AU  - Hofmann,O
AU  - Markowetz,F
AU  - McNeish,IA
AU  - Brenton,JD
DO  - 10.1038/s41588-018-0179-8
EP  - 1270
PY  - 2018///
SN  - 1061-4036
SP  - 1262
TI  - Copy-number signatures and mutational processes in ovarian carcinoma
T2  - Nature Genetics
UR  - http://dx.doi.org/10.1038/s41588-018-0179-8
UR  - https://www.nature.com/articles/s41588-018-0179-8
UR  - http://hdl.handle.net/10044/1/61593
VL  - 50
ER  -
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