Imperial College London
Portrait Picture

ProfessorIainMcNeish

Faculty of Medicine, Department of Surgery & Cancer

Chair in Oncology
 
 
 
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Contact

 

+44 (0)20 7594 2185i.mcneish Website

 
 
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Assistant

 

Ms Sophie Lions +44 (0)20 7594 2792

 
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Location

 

G036Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Blagih:2020:10.1016/j.celrep.2019.12.028,
author = {Blagih, J and Zani, F and Chakravarty, P and Hennequart, M and Pilley, S and Hobor, S and Hock, AK and Walton, JB and Morton, JP and Gronroos, E and Mason, S and Yang, M and McNeish, I and Swanton, C and Blyth, K and Vousden, KH},
doi = {10.1016/j.celrep.2019.12.028},
journal = {Cell Reports},
pages = {481--196.e6},
title = {Cancer-specific loss of p53 leads to a modulation of myeloid and T cell responses},
url = {http://dx.doi.org/10.1016/j.celrep.2019.12.028},
volume = {30},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Loss of p53 function contributes to the development of many cancers. While cell-autonomous consequences of p53 mutation have been studied extensively, the role of p53 in regulating the anti-tumor immune response is still poorly understood. Here, we show that loss of p53 in cancer cells modulates the tumor-immune landscape to circumvent immune destruction. Deletion of p53 promotes the recruitment and instruction of suppressive myeloid CD11b+ cells, in part through increased expression of CXCR3/CCR2-associated chemokines and macrophage colony-stimulating factor (M-CSF), and attenuates the CD4+ T helper 1 (Th1) and CD8+ T cell responses in vivo. p53-null tumors also show an accumulation of suppressive regulatory T (Treg) cells. Finally, we show that two key drivers of tumorigenesis, activation of KRAS and deletion of p53, cooperate to promote immune tolerance.
AU  - Blagih,J
AU  - Zani,F
AU  - Chakravarty,P
AU  - Hennequart,M
AU  - Pilley,S
AU  - Hobor,S
AU  - Hock,AK
AU  - Walton,JB
AU  - Morton,JP
AU  - Gronroos,E
AU  - Mason,S
AU  - Yang,M
AU  - McNeish,I
AU  - Swanton,C
AU  - Blyth,K
AU  - Vousden,KH
DO  - 10.1016/j.celrep.2019.12.028
EP  - 196
PY  - 2020///
SN  - 2211-1247
SP  - 481
TI  - Cancer-specific loss of p53 leads to a modulation of myeloid and T cell responses
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2019.12.028
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000507498100015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S221112471931678X?via%3Dihub
UR  - http://hdl.handle.net/10044/1/78122
VL  - 30
ER  -
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