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@article{Laird:2021:10.1007/s10753-021-01429-8,
author = {Laird, BJ and McMillan, D and Skipworth, RJE and Fallon, MT and Paval, R and McNeish, I and Gallagher, IJ},
doi = {10.1007/s10753-021-01429-8},
journal = {Inflammation},
pages = {1223--1228},
title = {The emerging role of Interleukin 1β (IL-1β) in cancer cachexia},
url = {http://dx.doi.org/10.1007/s10753-021-01429-8},
volume = {44},
year = {2021}
}

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TY  - JOUR
AB  - Treatment of cancer cachexia remains an unmet need. The host-tumour interface and the resulting sequestration of the pro-inflammatory cytokine Il-1β is critical in cachexia development. Neuroinflammation mediated via IL-1β through the hypothalamic pituitary axis results in increased muscle proteolysis and adipose lipolysis, thus creating a prolonged stress-like environment with loss of appetite and increased resting energy expenditure. Recent trials using a monoclonal antibody targeting IL-1β, canakinumab, have shown a potential role in lung cancer however a potential role of targeting IL-1β to treat cachexia in patients with lung cancer is unclear; yet the underlying pathophysiology provides a sound rationale that this may be a viable therapeutic approach.
AU  - Laird,BJ
AU  - McMillan,D
AU  - Skipworth,RJE
AU  - Fallon,MT
AU  - Paval,R
AU  - McNeish,I
AU  - Gallagher,IJ
DO  - 10.1007/s10753-021-01429-8
EP  - 1228
PY  - 2021///
SN  - 0360-3997
SP  - 1223
TI  - The emerging role of Interleukin 1β (IL-1β) in cancer cachexia
T2  - Inflammation
UR  - http://dx.doi.org/10.1007/s10753-021-01429-8
UR  - http://hdl.handle.net/10044/1/87482
VL  - 44
ER  -

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